Novel particulate vaccine candidates recombinantly produced by pathogenic and nonpathogenic bacterial hosts : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand. [PDF]
, 2017 Polyhydroxyalkanoates (PHAs) are biopolyesters synthesized as small spherical cytoplasmic inclusion bodies by a range of bacteria. Recently, PHA beads have been investigated for use as a vaccine delivery platform by using engineered heterologous ...
Lee, Jason Wong
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Advanced Functional Materials, Volume 36, Issue 33, 23 April 2026.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Polyhydroxyalkanoate (PHA) synthases (PhaCs) are key enzymes in PHA polymerization. PhaCs with broad substrate specificity are attractive for synthesizing structurally diverse PHAs.
Ramamoorthi M Sivashankari +7 more
doaj +1 more source
Novel polyhydroxyalkanoate beads for use as a vaccine against tuberculosis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatū, New Zealand [PDF]
, 2017 Tuberculosis was in 1993 declared as a re-emerging disease by the World Health Organization. The only vaccine currently available, BCG, an attenuated strain of Mycobacterium bovis, does not protect adults against the pulmonary disease, which is the ...
Rubio Reyes, Patricia
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Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 4, April 2026.ABSTRACT Large‐area bone loss from disease, trauma, or congenital defects requires surgical procedures and bone grafting. Alveolar bone loss from severe periodontal disease and non‐unions often demands immediate grafting. Treating large alveolar bone defects using grafts and substitutes is challenging due to the complex oral environment, infection ...
Allen Zennifer +5 more
wiley +1 more source
Toward Engineering the Substrate Specificity of a PHA Synthase (PhaC) [PDF]
, 2021 <p>Manufacturing of high-grade plastics from petroleum-based feedstocks is a high-cost, unsustainable process resulting in expensive products. My overall goal was to engineer the pathway of bacterial bio-polyester formation, in order to produce high-grade bioplastics.
openaire +1 more source
The Journal of Clinical Hypertension, 2023 The current screening and diagnostic recommendations for detecting Primary Hyperaldosteronism (PHA) focus on diagnosing the more severe and overt instances of renin‐independent aldosterone production.
Rajat Lamba
doaj +1 more source
Comparative metagenomics of PHA synthase genes in soil [PDF]
, 2017 Polyhydroxyalkanoates (PHAs) are biopolymers produced naturally by bacteria. They are of considerable scientific interest as fundamental components of bacterial carbon metabolism and have biotechnological applications as potential bioplastics.
Vahlis, Phuong Thi Ai
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Effects of Cardamom on Neuroinflammation, Learning and Memory in Mice Fed a Cafeteria Diet
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.Cardamom supplementation (500 mg/kg/day) improved memory, reduced anxiety and neuroinflammation in mice fed with a cafeteria diet. Behavioural tests showed enhanced cognitive functions, while TNF‐α and lipid markers decreased significantly. These findings suggest cardamom's potential as a neuroprotective agent against diet‐induced memory and metabolic ...
Anfal AL‐Dalaeen +2 more
wiley +1 more source
Studies on polyhydroxyalkanoate (PHA) accumulation in a PHA synthase I-negative mutant ofBurkholderia cepaciagenerated by homogenotization [PDF]
FEMS Microbiology Letters, 2000 In the genome of Burkholderia cepacia strain IPT64, which accumulates a blend of the two homopolyesters poly(3-hydroxybutyrate), poly(3HB), and poly(3-hydroxy-4-pentenoic acid), poly(3H4PE), from sucrose or gluconate as single carbon source, the polyhydroxyalkanoate (PHA) synthase structural gene was disrupted by the insertion of a chloramphenicol ...
M F, de Andrade Rodrigues +2 more
openaire +2 more sources