Results 51 to 60 of about 169,330 (288)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Phage Typing of Cholera Vibrio Strains of Serogroup O1, Isolated in the Territory of the Russian Federation in 2024

Проблемы особо опасных инфекций
Currently, cholera remains a relevant infectious disease that requires special vigilance from healthcare professionals and sanitary-epidemiological services.
N. E. Gaevskaya, Yu. V. Sizova, A. V. Tyurina, M. P. Pogozhova, V. D. Kruglikov, O. A. Bogdan   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysis of Salmonella enterica serotype Typhimurium by phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis

, 1999
Three typing methods commonly used for bacteria - phage typing, antimicrobial susceptibility and pulsed-field gel electrophoresis (PFGE) - were used to characterise 64 Salmonella enterica serotype Typhimurium isolates from individual adult patients from ...
Kimari, J, Kariuki, S, Gilks, C, Waiyaki, P, Hart, CA, Muyodi, J   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

ORIGINAL ARTICLE: Multidrug Resistance and Phage Pattern of Staphylococcus aureus in Pyoderma Cases [PDF]

Journal of Krishna Institute of Medical Sciences University, 2012
Background: Pyoderma is common in India and other tropical countries. Staphylococcus aureus is the commonest causative agent ofpyoderma. Aims and Objectives: To know the antibiotic susceptibility and bacteriophage pattern of Staphylococcus aureus ...
Sanjay M. Wavare, Sarita N. Kothadia, Mangala P. Ghatole   +2 more
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

PHAGE TYPING OF VIBRIO "EL TOR" [PDF]

Acta Medica Iranica, 1973
33 Stools from 518 patients suspected of having cholera were examined. From 174 of these patients Vibrio EI Tor was isolated. PO of these strains belonged to phage type IV, 53 to phage type V and one strain was untypable.
P. ADIBFAR
doaj   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Phage typing of Staphylococcus aureus [PDF]

Journal of Hygiene, 1953
Phage adsorption by resistant staphylococci was studied.Staphylococcal cultures previously allowed to adsorb phage to which they were resistant remained as sensitive to their appropriate phages as normal cultures of the same strains.When pooled related and unrelated phages were incubated with their propagating strains, the results resembled those ...
openaire   +2 more sources