Results 131 to 140 of about 171,183 (250)

Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae

mSystems
ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an alternative to antibiotics to eliminate multidrug-resistant (MDR) bacterial pathogens. However, optimizing the broad-spectrum efficacy of phage therapy remains a challenge.
Mengshi zhao, Hongru Li, Dehao Gan, Mengzhu Wang, Hui Deng, Qiu E. Yang   +5 more
openaire   +3 more sources

Computational Basis for On-Demand Production of Diversified Therapeutic Phage Cocktails

mSystems, 2020
The antibiotic resistance crisis has led to renewed interest in phage therapy as an alternative means of treating infection. However, conventional methods for isolating pathogen-specific phage are slow, labor-intensive, and frequently unsuccessful. We have demonstrated that computationally identified prophages carried by near-neighbor bacteria can ...
Catherine M. Mageeney, Anupama Sinha, Richard A. Mosesso, Douglas L. Medlin, Britney Y. Lau, Alecia B. Rokes, Todd W. Lane, Steven S. Branda, Kelly P. Williams   +8 more
openaire   +5 more sources

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, EarlyView.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

Isolation and Characterization of Specific Phages to Prepare a Cocktail Preventing Vibrio sp. Va-F3 Infections in Shrimp (Litopenaeus vannamei)

Frontiers in Microbiology, 2019
Vibrio is one of the most detrimental agents of shrimp premature death syndrome. Phage therapy for prevention and treatment of Vibrio infections has attracted increasing attentions due to the emergence of antibiotic-resistant bacterial variants. Here, we
Ling Chen, Ling Chen, Ling Chen, Ling Chen, Jiqiang Fan, Jiqiang Fan, Jiqiang Fan, Tingwei Yan, Quan Liu, Shengjian Yuan, Shengjian Yuan, Shengjian Yuan, Shengjian Yuan, Haoran Zhang, Haoran Zhang, Jinfang Yang, Deng Deng, Shuqiang Huang, Shuqiang Huang, Shuqiang Huang, Yingfei Ma, Yingfei Ma, Yingfei Ma, Yingfei Ma   +23 more
doaj   +1 more source

Pseudolysogeny and sequential mutations build multiresistance to virulent bacteriophages in Pseudomonas aeruginosa [PDF]

, 2016
International audienceCoevolution between bacteriophages and their prey is the result of mutualistic interactions. Here we show that pseudolysogeny is a frequent outcome of infection by virulent phages of Pseudomonas aeruginosa, and that selection of ...
Hauck, Yolande, Latino, Libera, Midoux, Cédric, Pourcel, Christine, Vergnaud, Gilles   +4 more
core   +2 more sources

Potential for Natural Antimicrobials, Including Mushroom Chitosan, to Control Shiga‐Toxigenic Escherichia coli in Ground Beef

Journal of Food Safety, Volume 46, Issue 2, April 2026.
This study evaluated the antimicrobial activity of 11 natural agents against eight STEC serotypes by determining their MIC and MBC at different pH and temperature conditions. Five agents demonstrating the strongest inhibitory activity in vitro were then tested at various concentrations in beef burgers inoculated with Escherichia coli O157 and stored ...
Angelos Papadochristopoulos, Joseph P. Kerry, Narelle Fegan, Catherine M. Burgess, Geraldine Duffy   +4 more
wiley   +1 more source

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity [PDF]

, 2008
Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected.
Bugg, Charles W., Dunn, Denise E., Khoshnan, Ali, Lo, Donald C., Patterson, Paul H., Southwell, Amber L.   +5 more
core   +2 more sources

Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin‐Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model

Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.
Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk   +9 more
wiley   +1 more source

Inter-Species Competition of Mono- or Dual Species Biofilms- of MDR-Staphylococcus aureus and Pseudomonas aeruginosa Promotes the Killing Efficacy of Phage or Phage Cocktail

Applied microbiology
Pseudomonas aeruginosa and Staphylococcus aureus are opportunistic bacteria frequently linked to burn wound infections. These bacteria can grow as biofilms, which increases their level of drug resistance to current antibiotics. The purpose of the present
Pallavali Rojarani, G. D. Reddy, D. Vijayalakshmi, D. R. Prasad, Jeonghwa Choi   +4 more
semanticscholar   +1 more source

SocialViruses: integrating quantitative phage–bacteria and phage–phage interaction networks for rational cocktail design

Bioinformatics Advances
Abstract Motivation Phage therapy is emerging as a promising alternative to antibiotics in biomedical research, highlighting the growing need for computational tools to rationally design effective phage cocktails.
Felipe Molina, Manuel Menor-Flores, Miguel A Vega-Rodríguez   +2 more
openaire   +2 more sources