Results 201 to 210 of about 171,183 (250)

Shopping for phages? Unpacking design rules for therapeutic phage cocktails

Current Opinion in Virology, 2022
In bacteriophage therapy, the combination of different phages into a single cocktail is of critical importance to overcome the narrow host range of single phage isolates. Today, the design of therapeutic cocktails is often akin to a black box and relies largely on intuition and (pre-)availability of isolates in local collections.
Cédric Lood, Pieter-Jan Haas, Vera van Noort, Rob Lavigne   +3 more
openaire   +2 more sources

Computational design of phage cocktails based on phage-bacteria infection networks

Computers in Biology and Medicine, 2022
The misuse and overuse of antibiotics have boosted the proliferation of multidrug-resistant (MDR) bacteria, which are considered a major public health issue in the twenty-first century. Phage therapy may be a promising way in the treatment of infections caused by MDR pathogens, without the side effects of the current available antimicrobials.
Manuel Menor-Flores, Miguel A. Vega-Rodríguez, Felipe Molina   +2 more
openaire   +2 more sources

New Phage cocktail against infantile Sepsis bacteria

Microbial Pathogenesis, 2020
A total of 54 positive blood aerobic cultures of suspected blood sepsis in neonates were purified, diagnosed and tested for antibiotic susceptibility. Six bacterial pathogens of Escherichia coli (10 isolates), Klebsiella pneumoniae (10 isolates), Haemophilus influenzae (4 isolates), Pseudomonas aeruginosa (3 isolates), Citrobacter fruendii (1 isolate ...
Sadeq Abdulridha, Gatea Kaabi, Hadeel Kareem, Musafer   +1 more
openaire   +2 more sources

Host happy hour: Phage cocktail targets IBD-associated microbes

Cell Host & Microbe, 2022
Bacteriophage therapy is a promising strategy to treat bacterial infections and sculpt the microbiome. In a recent Cell paper, Federici et al. (2022) demonstrate that a Klebsiella pneumoniae phage cocktail can specifically remove pathobionts from the mouse gut. Safety and persistence of therapeutic phages were shown in a Phase 1 trial.
Jay, Fuerte-Stone, Mark, Mimee
openaire   +2 more sources

Phage and phage cocktails formulations

2023
Antibiotic-resistant bacterial infection is a major global problem and can be life-threatening. Bacteriophages or phages can be substituted choice over traditional antibiotics treatments. Phages are natural obligate parasites viruses of bacteria, and they can infect and kill antibiotic-sensitive and -resistant bacteria.
openaire   +2 more sources

Phage Cocktail Therapy: Multiple Ways to Suppress Pathogenicity

Trends in Plant Science, 2020
Phage cocktails have emerged as precision tools for controlling plant bacterial diseases. Wang et al. now report that phage cocktails decreased the occurrence of tomato bacterial wilt disease efficiently by infecting and destroying bacterial pathogens, selecting phage-resistant but slow-growing pathogen strains, and fostering bacterial species that are
Na, Liu, Connor, Lewis, Wenming, Zheng, Zheng Qing, Fu   +3 more
openaire   +2 more sources

A Novel Method to Create Efficient Phage Cocktails via Use of Phage-Resistant Bacteria

Applied and Environmental Microbiology, 2022
The rapid antiphage mutation of pathogens is a big challenge often encountered in phage therapy. Using a cocktail composed of phages with different infection strategies can better overcome this problem.
Chengcheng Li, Tongmei Shi, Yuechao Sun, Yongyu Zhang   +3 more
openaire   +2 more sources

Employment of the Phage Cocktail as a Species-Specific Recognition Agent for Wide-Spectrum Detection of Bacterial Strains.

Analytical Chemistry, 2023
Phages have already been employed to detect bacteria because of their specific recognition capability and strong infectious activity toward their host.
Honglin Yang, Zong Gou, Hongwei Yuan, Xin Yue, Shuguang Lu, Zhifeng Fu   +5 more
semanticscholar   +1 more source

Effectiveness of a single-dose phage cocktail on the reduction of multidrug-resistant Escherichia coli in suckling piglets.

Veterinary Microbiology
Antibiotics are commonly used in pig farming to control infections caused by diarrhea-causing Escherichia coli (E. coli). However, improper or excessive use of antibiotics in pigs can enhance antibiotic resistance (ABR).
Viphavanh Chanthavong, Nattha Vigad, Wattana Pelyuntha, D. Y. Yamik, K. Vongkamjan, Mingkwan Yingkajorn, Warangkhana Chaisowwong, Kittiphong Tippaya, Phacharaporn Tadee, Kridda Chukiatsiri   +9 more
semanticscholar   +1 more source

Phage cocktail against Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease (AHPND) in Penaeus vannamei: genomic, biological, and pathological characterization.

Microbial Pathogenesis
Phages vB_Pd_PDCC-1, vB_Vc_SrVc9, and vB_Vp_PvVp11 were found to be lytic against Vibrio parahaemolyticus acute hepatopancreatic necrosis disease (AHPND) and other pathogenic vibrios.
S. Soto-Rodriguez, E. Quiroz‐Guzmán, Bruno Gómez-Gil, R. Lozano‐Olvera, K. G. Aguilar-Rendón, Juan Manuel Serrano-Hernández, J. González-Gómez, C. Chaidez   +7 more
semanticscholar   +1 more source