Results 271 to 280 of about 165,430 (355)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Bacteria-phage infection network structure and genomic defence system content predict efficacy of a phage therapy cocktail against <i>Pseudomonas aeruginosa</i> from chronic lung infections. [PDF]

Philos Trans R Soc Lond B Biol Sci
Czernuszka MR, Fu T, Kottara A, Brockhurst MA, Wright RCT.   +4 more
europepmc   +1 more source

Genome comparison of phage phiAGATE, other members of the Bastille group, phage SPO1, and phage Twort, visualized with BRIG.

, 2014
Jakub Barylski, Grzegorz Nowicki, Goździcka-Józefiak Anna   +2 more
openalex   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Lineage-specific defence systems of pandemic <i>Vibrio cholerae</i>. [PDF]

Philos Trans R Soc Lond B Biol Sci
Blokesch M, Seed KD.
europepmc   +1 more source

Microbial diversity and function in the rhizosphere microbiome: Driving forces and monitoring approaches

Agrosystems, Geosciences &Environment, Volume 8, Issue 3, September 2025.
Abstract As an ecological unit, the rhizosphere microbiome preserves an enormous and largely unexplored diversity of microbes that play essential roles in plant health and soil functions. Omics technologies encompassing high‐throughput approaches such as metagenomics, metatranscriptomics, and metaproteomics provide helpful tools to unravel the ...
Chinenyenwa Fortune Chukwuneme, Olubukola Oluranti Babalola   +1 more
wiley   +1 more source

Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in <i>Pseudomonas aeruginosa</i> is nutrient dependent. [PDF]

Philos Trans R Soc Lond B Biol Sci
Elliott JFK, Cozens K, Cai Y, Waugh G, Watson BN, Westra E, Taylor TB.   +6 more
europepmc   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Lytic bacteriophages targeting multidrug-resistant Pseudomonas aeruginosa in Moschus berezovskii: isolation, characterization, and therapeutic efficacy against bacteremia. [PDF]

Virol J
Hu Q, Zhang Y, Lv N, Kang Y, Nasir S, Wang R, Qu J, Jiang J, Li X, Wang X.   +9 more
europepmc   +1 more source