Results 281 to 290 of about 165,430 (355)

Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung, Dany Perocheau, Roopkatha Ghosh, Stephen L. Hart, Julien Baruteau   +4 more
wiley   +1 more source

Genome sequences of two <i>Escherichia coli</i> bacteriophages isolated from activated sludge in domestic wastewater treatment plants. [PDF]

Microbiol Resour Announc
Nittami T, Motoyama K, Sasaki M, Fujii Y, Batinovic S, Kabwe M, Tucci J.   +6 more
europepmc   +1 more source

Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu, Yongyi Xie, Wenjie Chen, Wei Deng   +3 more
wiley   +1 more source

Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against <i>Serratia marcescens</i>. [PDF]

Microbiol Spectr
Li L, Li K, Mi Y, Wu X, Zhong Y, Zhang C, Wang P, Zhao H.   +7 more
europepmc   +1 more source

Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances

MedComm, Volume 6, Issue 9, September 2025.
Key pathogenic mechanisms—OXPHOS defects, heteroplasmy, impaired mtDNA repair, disrupted dynamics/mitophagy, and inflammatory signaling—drive multiorgan involvement in mitochondrial diseases. Targeted interventions include metabolic drugs (CoQ10, idebenone, EPI‐743), mitochondrial gene editing (DdCBE, mitoBEs, CyDENT/mitoTALEN/mtZFN), and mitochondrial
Jialun Mei, Peng Ding, Chuan Gao, Jian Zhou, Zhiwei Li, Changqing Zhang, Junjie Gao   +6 more
wiley   +1 more source

Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing. [PDF]

Proc Natl Acad Sci U S A
Roberts A, Adler BA, Cress BF, Doudna JA, Barrangou R.   +4 more
europepmc   +1 more source

Interactions of rare earth elements with living organisms and emerging biotechnical applications

PLANTS, PEOPLE, PLANET, Volume 7, Issue 5, Page 1251-1274, September 2025.
Rare earth elements (REEs) are critical resources required to achieve net‐zero carbon emission targets and energy security. However, rising demand for REEs coupled with significant extraction and processing challenges and geopolitical risks restricts access to REE resources.
Samantha A. McGaughey, Shagufta Iqbal, Annamaria De Rosa, Jessica A. Caley, Anna H. Kaksonen, Denys Villa‐Gomez, Caitlin S. Byrt   +6 more
wiley   +1 more source

Phage pAEv1: A potential biocontrol agent against <i>Aeromonas veronii</i> infections. [PDF]

Virulence
Zhang T, Jiang S, Dai R, Zhou Y, Long S, He M, Zhou B, Tang T, Yang L, Zhong W, Xiao W, Fu Y, Guo J, Gao Z.   +13 more
europepmc   +1 more source

Comparative analysis of the extent of protein–protein interactions in icosahedral viral capsids

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Nonenveloped viruses package, carry, and deliver their genomes to the targeted cells using protein shells known as capsids. The viral capsids come in different shapes and sizes, most exhibiting helical or icosahedral symmetries. Here, we analyzed 634 icosahedral capsids at high resolution (<4 Å) from 39 virus families with T‐numbers ranging ...
Noah J. Zimmerman, Oscar Rojas Labra, Vijay S. Reddy   +2 more
wiley   +1 more source