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Phage Diversity, Genomics and Phylogeny [PDF]
Nature Reviews Microbiology, 2020 Recent advances in viral metagenomics have enabled the rapid discovery of an unprecedented catalogue of phages in numerous environments, from the human gut to the deep ocean. Although these advances have expanded our understanding of phage genomic diversity, they also revealed that we have only scratched the surface in the discovery of novel viruses ...
Sylvain Moineau +2 more
exaly +3 more sources
Characterizing Phage Genomes for Therapeutic Applications [PDF]
Viruses, 2018 Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be approved for wide-spread use in the US.
Regina Z Cer +2 more
exaly +4 more sources
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002
Marine phages are the most abundant biological entities in the oceans. They play important roles in carbon cycling through marine food webs, gene transfer by transduction and conversion of hosts by lysogeny. The handful of marine phage genomes that have been sequenced to date, along with prophages in marine bacterial genomes, and partial sequencing of ...
John H, Paul +3 more
openaire +2 more sources
Marine phages are the most abundant biological entities in the oceans. They play important roles in carbon cycling through marine food webs, gene transfer by transduction and conversion of hosts by lysogeny. The handful of marine phage genomes that have been sequenced to date, along with prophages in marine bacterial genomes, and partial sequencing of ...
John H, Paul +3 more
openaire +2 more sources
The genomes and comparative genomics of Lactobacillus delbrueckii phages
Archives of Virology, 2011Lactobacillus delbrueckii phages are a great source of genetic diversity. Here, the genome sequences of Lb. delbrueckii phages LL-Ku, c5 and JCL1032 were analyzed in detail, and the genetic diversity of Lb. delbrueckii phages belonging to different taxonomic groups was explored.
Katja-Anneli, Riipinen +2 more
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Phage DNA Extraction, Genome Assembly, and Genome Closure
2023Bacteriophages, or more simply phages, are currently experiencing a renaissance in life science research for their roles in natural microbial communities, their potential use as antimicrobials, and biotechnological applications. In the modern era, one of the primary steps in phage characterization is obtaining the sequence of the complete genome; this ...
Justin, Boeckman +3 more
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Phage Genome Engineering With Retrons
Nature BiotechnologyIlya Osterman, Rotem Sorek
exaly +3 more sources
Phage Genome Annotation Using the RAST Pipeline
Methods in Molecular Biology, 2018 Phages are complex biomolecular machineries that have to survive in a bacterial world. Phage genomes show many adaptations to their lifestyle such as shorter genes, reduced capacity for redundant DNA sequences, and the inclusion of tRNAs in their genomes.
Robert A Edwards +2 more
exaly +1 more source
Cell Host & Microbe
Deciphering the relationship between bacteriophage genotypes and phenotypes has been limited by a lack of genetic tractability and high-throughput screening methods. In this issue of Cell Host & Microbe, Chen et al. establish PhageMaP for generating phage mutant libraries to systematically interrogate phage gene function.
Shelby E. Andersen, Breck A. Duerkop
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Deciphering the relationship between bacteriophage genotypes and phenotypes has been limited by a lack of genetic tractability and high-throughput screening methods. In this issue of Cell Host & Microbe, Chen et al. establish PhageMaP for generating phage mutant libraries to systematically interrogate phage gene function.
Shelby E. Andersen, Breck A. Duerkop
openaire +2 more sources
The Genome of φAsp2, an Actinoplanes Infecting Phage
Virus Genes, 2004The first genome of a virus infecting a representative of the eubacterial genus Actinoplanes is presented. Phage phiAsp2 has a circularly permutated chromosome that consists of 58,638 bp; its G/C-bias of 70.39% resembles the hosts G + C-content (71-73% within the genus).
Martin, Jarling +3 more
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