Results 1 to 10 of about 28,777,576 (349)

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

SST gene hypermethylation acts as a pan‐cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood‐based diagnosis

Molecular Oncology, 2020
Aberrant DNA methylation is often involved in carcinogenesis. Our initial goal was to identify DNA methylation biomarkers associated with pancreatic cancer.
Mehdi Manoochehri, Yenan Wu, Nathalia A. Giese, Oliver Strobel, Stefanie Kutschmann, Florian Haller, Jörg D. Hoheisel, Evgeny A. Moskalev, Thilo Hackert, Andrea S. Bauer   +9 more
doaj   +1 more source

DNA methylation analysis of porcine mammary epithelial cells reveals differentially methylated loci associated with immune response against Escherichia coli challenge

BMC Genomics, 2019
Background Epigenetic changes such as cytosine (CpG) DNA methylations regulate gene expression patterns in response to environmental cues including infections.
Basavaraj Sajjanar, Nares Trakooljul, Klaus Wimmers, Siriluck Ponsuksili   +3 more
doaj   +1 more source

Substantial regional variation in substitution rates in the human genome: importance of GC content, gene density and telomere-specific effects [PDF]

, 2005
This study presents the first global, 1 Mbp level analysis of patterns of nucleotide substitutions along the human lineage. The study is based on the analysis of a large amount of repetitive elements deposited into the human genome since the mammalian ...
Arndt, Peter F, Hwa, Terence, Petrov, Dmitri A   +2 more
core  

Genome-wide Efficient Mixed Model Analysis for Association Studies

Nature Genetics, 2012
Linear mixed models have attracted considerable attention recently as a powerful and effective tool for accounting for population stratification and relatedness in genetic association tests.
Xiaoping Zhou, M. Stephens
semanticscholar   +1 more source

Fast Genome-Wide QTL Analysis Using Mendel

, 2014
Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis.
Hu, Tao, Lange, Kenneth, Sobel, Eric M, Zhou, Hua, Zhou, Jin   +4 more
core  

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Nature Genetics, 2019
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain.
I. Jansen, J. Savage, Kyoko Watanabe, J. Bryois, Dylan M. Williams, S. Steinberg, J. Sealock, I. Karlsson, S. Hägg, L. Athanasiu, N. Voyle, P. Proitsi, Aree Witoelar, S. Stringer, D. Aarsland, I. Almdahl, Fred Andersen, S. Bergh, F. Bettella, Sigurbjorn Bjornsson, Anne Brækhus, G. Bråthen, C. D. de Leeuw, R. Desikan, S. Djurovic, L. Dumitrescu, T. Fladby, T. Hohman, P. Jonsson, S. Kiddle, A. Rongve, I. Saltvedt, S. Sando, G. Selbæk, M. Shoai, N. Skene, J. Snaedal, E. Stordal, I. Ulstein, Yunpeng Wang, L. White, J. Hardy, J. Hjerling-Leffler, P. Sullivan, W. M. van der Flier, R. Dobson, L. Davis, H. Stefánsson, K. Stefánsson, N. Pedersen, S. Ripke, O. Andreassen, D. Posthuma   +52 more
semanticscholar   +1 more source

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

BMC Cancer, 2019
Background Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src ...
Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu, Yi Zhang   +6 more
doaj   +1 more source

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Nature Communications, 2017
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control ...
C. Adema, L. Hillier, Catherine S. Jones, E. Loker, M. Knight, P. Minx, Guilherme C. Oliveira, N. Raghavan, A. Shedlock, L. D. do Amaral, Halime D. Arican-Goktas, Juliana Assis, É. H. Babá, O. Baron, C. Bayne, Utibe Bickham-Wright, K. Biggar, M. Blouin, B. Bonning, C. Botka, J. Bridger, Katherine M. Buckley, S. Buddenborg, Roberta Lima Caldeira, Julia B. Carleton, O. Carvalho, M. Castillo, Iain W. Chalmers, Mikkel Christensens, S. Clifton, C. Cosseau, C. Coustau, R. Cripps, Yesid Cuesta-Astroz, S. Cummins, Leon di Stephano, N. Dinguirard, D. Duval, S. Emrich, C. Feschotte, R. Feyereisen, P. FitzGerald, Catrina C. Fronick, L. Fulton, R. Galinier, Sandra Grossi Gava, M. Geusz, Kathrin K. Geyer, Gloria I. Giraldo-Calderón, M. de Souza Gomes, M. A. Gordy, B. Gourbal, C. Grunau, P. Hanington, K. Hoffmann, Daniel Hughes, J. Humphries, D. Jackson, Liana K. Jannotti-Passos, Wander De Jesus Jeremias, S. Jobling, Bishoy Kamel, A. Kapusta, Satwant Kaur, J. Koene, A. Kohn, D. Lawson, S. Lawton, Di Liang, Yanin Limpanont, Sijun Liu, A. Lockyer, TyAnna L. Lovato, Fernanda Ludolf, V. Magrini, D. McManus, M. Medina, M. Misra, G. Mitta, G. Mkoji, M. Montague, C. Montelongo, L. Moroz, M. Munoz-Torres, U. Niazi, L. Noble, Francislon S. Oliveira, F. Pais, A. Papenfuss, R. Peace, Janeth J. Peña, Emmanuel A. Pila, Titouan Quelais, B. Raney, J. Rast, D. Rollinson, I. Rosse, B. Rotgans, E. Routledge, K. M. Ryan, L. Scholte, K. Storey, M. Swain, Jacob A. Tennessen, Chad Tomlinson, D. Trujillo, E. Volpi, A. J. Walker, Tianfang Wang, Ittiprasert Wannaporn, W. Warren, Xiao-jun Wu, T. Yoshino, Mohammed Yusuf, Si-Ming Zhang, Min Zhao, R. Wilson   +116 more
semanticscholar   +1 more source

In situ, Cell-free Protein Expression on Microarrays and Their Use for the Detection of Immune Responses

Bio-Protocol, 2019
Until recently, whole-proteome microarrays for comprehensive studies of protein interactions were mostly produced by individual cloning and cellular expression of very many open reading frames, followed by protein isolation and purification as well as ...
Katrin Hufnagel, Dennis Reininger, Siu Ng, Nadine Gassert, Juliane Rohland, Soroosh Shahryarhesami, Andrea Bauer, Tim Waterboer, Jörg Hoheisel   +8 more
doaj   +1 more source