Results 31 to 40 of about 28,777,576 (349)
BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]
, 2016 Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien +7 more
core +2 more sources
Genome Research, 2010 Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are already revolutionizing our understanding of genetic variation among individuals.
A. McKenna +10 more
semanticscholar +1 more source
RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells
Molecular Therapy: Nucleic Acids, 2022 Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids.
Jiamiao Lu +9 more
doaj +1 more source
Current Protocols in Bioinformatics, 2013 This unit describes how to use BWA and the Genome Analysis Toolkit (GATK) to map genome sequencing data to a reference and produce high‐quality variant calls that can be used in downstream analyses.
G. Auwera +14 more
semanticscholar +1 more source
Comparative Genomics and Functional Genomics Analysis in Plants
International Journal of Molecular Sciences, 2023 Comparative genomics and functional genomics are two basic branches of plant genomics [...]
Jiacheng Wang, Yaojia Chen, Quan Zou
openaire +2 more sources
Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis [PDF]
BMC Genomics, 2011 AbstractBackgroundRoseobacter litoralisOCh149, the type species of the genus, andRoseobacter denitrificansOCh114 were the first described organisms of theRoseobacterclade, an ecologically important group of marine bacteria. Both species were isolated from seaweed and are able to perform aerobic anoxygenic photosynthesis.ResultsThe genome ofR ...
Kalhoefer, Daniela +8 more
openaire +4 more sources
Graph-Based Genome Alignment and Genotyping with HISAT2 and HISAT-genotype
Nature Biotechnology, 2019 The human reference genome represents only a small number of individuals, which limits its usefulness for genotyping. We present a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA ...
Daehwan Kim +4 more
semanticscholar +1 more source
Comparative genome analysis of Wolbachia strain wAu [PDF]
, 2014 BACKGROUND: Wolbachia intracellular bacteria can manipulate the reproduction of their arthropod hosts, including inducing sterility between populations known as cytoplasmic incompatibility (CI). Certain strains have been identified that are unable to
Harris, Simon R. +3 more
core +2 more sources
Coronavirus Genomics and Bioinformatics Analysis [PDF]
Viruses, 2010 The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, with G + C contents varying from 32% to 43%.
Woo, PCY, Lau, SKP, Yuen, KY, Huang, Y
openaire +5 more sources
F1000Research, 2014 Modern sequencing platforms generate enormous quantities of data in ever-decreasing amounts of time. Additionally, techniques such as multiplex sequencing allow one run to contain hundreds of different samples.
Ricardo H. Ramirez-Gonzalez +6 more
doaj +1 more source