Results 21 to 30 of about 28,777,576 (349)
Molecular Therapy: Methods & Clinical Development, 2020 Recombinant adeno-associated virus (rAAV) vectors are a leading gene delivery platform, but vector manufacturing remains a challenge. New methods are needed to increase rAAV yields and reduce costs. Past efforts to improve rAAV production have focused on
Huiren Zhao +8 more
doaj +1 more source
Comprehensive pan‐genome analysis of Lactiplantibacillus plantarum complete genomes
Journal of Applied Microbiology, 2021 The aim of this work was to refine the taxonomy and the functional characterization of publicly available Lactiplantibacillus plantarum complete genomes through a pan‐genome analysis.
F. Carpi +5 more
semanticscholar +1 more source
Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction
Scientific Reports, 2021 Heart failure with reduced ejection fraction (HFrEF) constitutes 50% of HF hospitalizations and is characterized by high rates of mortality. To explore the underlying mechanisms of HFrEF etiology and progression, we studied the molecular and cellular ...
Xin Luo +12 more
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Accelerating Genome Analysis: A Primer on an Ongoing Journey [PDF]
IEEE Micro, 2020 Genome analysis fundamentally starts with a process known as read mapping, where sequenced fragments of an organism's genome are compared against a reference genome.
M. Alser +6 more
semanticscholar +1 more source
BMC Cancer, 2021 Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches ...
Chiara Giacomelli +12 more
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npj Breast Cancer, 2023 Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer.
Lukas Beumers +14 more
doaj +1 more source
Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing [PDF]
PeerJ, 2013 Exosomes are nanosized (30–100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes.
Piroon Jenjaroenpun +5 more
doaj +2 more sources
Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]
, 2009 OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC +9 more
core +1 more source
Roary: rapid large-scale prokaryote pan genome analysis
bioRxiv, 2015 Summary A typical prokaryote population sequencing study can now consist of hundreds or thousands of isolates. Interrogating these datasets can provide detailed insights into the genetic structure of of prokaryotic genomes.
Andrew J. Page +9 more
semanticscholar +1 more source
Sequencing quality assessment tools to enable data-driven informatics for high throughput genomics
Frontiers in Genetics, 2013 The processes of quality assessment and control are an active area of research at The Genome Analysis Centre (TGAC). Unlike other sequencing centres that often concentrate on a certain species or technology, TGAC applies expertise in genomics and ...
Richard Mark Leggett +4 more
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