Results 21 to 30 of about 1,597,445 (261)

A method to simultaneously construct up to 12 differently sized Illumina Nextera long mate pair libraries with reduced DNA input, time, and cost

BioTechniques, 2015
Long mate pair (LMP) or “jump” libraries are invaluable for producing contiguous genome assemblies and assessing structural variation. However the consistent production of high quality (low duplication rate, accurately sized) LMP libraries has proven ...
Darren Heavens, Gonzalo Garcia Accinelli, Bernardo Clavijo, Matthew Derek Clark   +3 more
doaj   +1 more source

Genomic Analysis in the Age of Human Genome Sequencing [PDF]

Cell, 2019
Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of human genomes as part of various gene ...
Tuuli, Lappalainen, Alexandra J, Scott, Margot, Brandt, Ira M, Hall   +3 more
openaire   +2 more sources

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

BMC Genomics, 2017
Background High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease ...
Vladimir A. Kuznetsov, Zhiqun Tang, Anna V. Ivshina   +2 more
doaj   +1 more source

The complete chloroplast genome of Sinomenium acutum (Menispermaceae)

Mitochondrial DNA. Part B. Resources, 2020
We generated the complete chloroplast genome sequence of Sinomenium acutum, a species of the Menispermaceae family, and characterized from the de novo assembly of Illumina HiSeq paired-end sequencing data. The total length of the chloroplast genome of S.
Jinhyuk Kim, Junki Lee, Sanghee Um, Sunseong Choi, Hyojin Kim, Hyang Sook Chun, Gyoungju Nah   +6 more
doaj   +1 more source

The complete chloroplast genome of Typhonium giganteum (Araceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome sequence of Typhonium giganteum, a species of the Araceae family, was characterized from the de novo assembly of HiSeq (Illumina Co.) paired-end sequencing data. The chloroplast genome of T.
Jinhyuk Kim, Junki Lee, Sunseong Choi, Sanghee Um, Hyojin Kim, Hyang Sook Chun, Gyoungju Nah   +6 more
doaj   +1 more source

Coordinated transcriptional and post-transcriptional epigenetic regulation during skeletal muscle development and growth in pigs

Journal of Animal Science and Biotechnology, 2022
Background N6-methyladenosine (m6A) and DNA 5-methylcytosine (5mC) methylation plays crucial roles in diverse biological processes, including skeletal muscle development and growth.
Du Zhang, Shumei Wu, Xinxin Zhang, Shuqiang Ren, Zhonglin Tang, Fei Gao   +5 more
doaj   +1 more source

Antibody Microarrays: Promises and Problems

BioTechniques, 2002
Antibody microarrays have enormous potential for becoming a tool that will allow, at the protein level, the type of global characterization of molecular mixtures that DNA microarrays already make possible at the RNA and DNA level.
Wlad Kusnezow, Jörg D. Hoheisel
doaj   +1 more source

Complete chloroplast genome of Gypsophila oldhamiana Miq. (Caryophyllales: Caryophyllaceae)

Mitochondrial DNA. Part B. Resources, 2021
The complete chloroplast genome sequence of Gypsophila oldhamiana Miq., a species of the Caryophyllaceae family, was assembled and analyzed from the de novo assembly of Illumina paired-end sequencing data. The total length of the chloroplast genome of G.
Ji Ran Jeong, Hyun Jo Koo, Heesu Yun, Hyang Sook Chun, Sang-Il Han, Gyoungju Nah   +5 more
doaj   +1 more source

Whole-exome sequencing uncovered the 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as the cause of lethal in a Vietnamese infant [PDF]

Exploration of Endocrine and Metabolic Diseases
Metabolic disorders are due to a deficiency of enzymes, which can severely impact health or cause serious complications without treatment. This study aimed to identify the molecular causes of an infant death who had been hospitalized with complicated ...
Hong Thu Nguyen-Huu, Khanh Linh Nguyen, Phuong Nhung Vu, Hai Ha Nguyen   +3 more
doaj   +1 more source

5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

Journal of Experimental & Clinical Cancer Research, 2022
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner   +19 more
doaj   +1 more source