Results 41 to 50 of about 25,229,043 (255)

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-, Dieter Ebert, Karen L Haag, Haag, Karen L, Nicolas Corradi, Patrick J Keeling, Keeling, Patrick J, Jean-François Pombert   +17 more
core   +1 more source

Whole-exome sequencing uncovered the 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as the cause of lethal in a Vietnamese infant [PDF]

Exploration of Endocrine and Metabolic Diseases
Metabolic disorders are due to a deficiency of enzymes, which can severely impact health or cause serious complications without treatment. This study aimed to identify the molecular causes of an infant death who had been hospitalized with complicated ...
Hong Thu Nguyen-Huu, Khanh Linh Nguyen, Phuong Nhung Vu, Hai Ha Nguyen   +3 more
doaj   +1 more source

5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

Journal of Experimental & Clinical Cancer Research, 2022
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner   +19 more
doaj   +1 more source

Analysis of high-identity segmental duplications in the grapevine genome [PDF]

, 2011
Background Segmental duplications (SDs) are blocks of genomic sequence of 1-200 kb that map to different loci in a genome and share a sequence identity > 90%.
VENTURA, MARIO, D'ADDABBO, PIETRO, Donato Antonacci, Mario Ventura, Ventura M, Ventura Mario, Giuliana Giannuzzi, Maurizio Martinelli, Marica Gasparro, Antonacci D, Gasparro Marica, Giannuzzi Giuliana, D'Addabbo P, D'Addabbo Pietro, Martinelli M, Martinelli Maurizio, Giannuzzi G, Pietro D'Addabbo, Carelli Francesco N, Francesco N Carelli, Antonacci Donato, Gasparro M, Carelli FN   +22 more
core   +2 more sources

Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment

Microbiome, 2017
Background Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C.
Sepideh Pakpour, Amit Bhanvadia, Roger Zhu, Abhimanyu Amarnani, Sean M. Gibbons, Thomas Gurry, Eric J. Alm, Laura A. Martello   +7 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

Nature Communications, 2022
This paper proposed a novel in-silico framework for automatically screening disease-related variants and applied it to over 200,000 transcriptomes, providing an example to acquire medically relevant knowledge from publicly available sequence data.
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raúl Nicolás Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi   +9 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

CoryneCenter: an online resource for the integrated analysis of corynebacterial genome and transcriptome data [PDF]

, 2007
Neuweger H, Baumbach J, Albaum S, et al. CoryneCenter: an online resource for the integrated analysis of corynebacterial genome and transcriptome data. BMC Systems Biology.
Hüser, Andrea T., Andrea T Hüser, Sven Rahmann, Albaum, Stefan ; https://orcid.org/, Neuweger, Heiko, Jochen Weile, Weile, Jochen, Goesmann, Alexander ; https://orcid.org/, Stefan Albaum, Thomas Bekel, Baumbach, Jan, Bekel, Thomas, Pühler, Alfred ; https://orcid.org/, Sebastian Oehm, Michael Dondrup, Heiko Neuweger, Jan Baumbach, Kalinowski, Jörn, Alfred Pühler, Dondrup, Michael, Oehm, Sebastian, Alexander Goesmann, Rahmann, Sven, Jörn Kalinowski   +23 more
core   +1 more source

Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics

BMC Genetics, 2020
Background In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and ...
Yue Hu, Yihe Zhang, Cong Liu, Rui Qin, Desheng Gong, Ru Wang, Du Zhang, Lianqiang Che, Daiwen Chen, Guizhong Xin, Fei Gao, Qi Hu   +11 more
doaj   +1 more source