Results 41 to 50 of about 28,777,576 (349)
F1000Research, 2013 Modern sequencing platforms generate enormous quantities of data in ever-decreasing amounts of time. Additionally, techniques such as multiplex sequencing allow one run to contain hundreds of different samples.
Ricardo H. Ramirez-Gonzalez +6 more
doaj +1 more source
Genome maps across 26 human populations reveal population-specific patterns of structural variation. [PDF]
, 2019 Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in ...
Cao, Han +25 more
core +2 more sources
BMC Genomics, 2019 Background Epigenetic variation may result from selection for complex traits related to metabolic processes or appear in the course of adaptation to mediate responses to exogenous stressors.
Siriluck Ponsuksili +5 more
doaj +1 more source
Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data [PDF]
, 2019 BACKGROUND: Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps.
Eller, Ryan J. +2 more
core +1 more source
Nucleic Acids Res., 2018 Proteins and their functional interactions form the backbone of the cellular machinery. Their connectivity network needs to be considered for the full understanding of biological phenomena, but the available information on protein–protein associations is
Damian Szklarczyk +11 more
semanticscholar +1 more source
Genomic Microarray Analysis [PDF]
, 2015 Microarrays utilize classical hybridization techniques to measure the levels of expression of genomic sequences. Advances in microarray fabrication using robotic technology and bioinformatics, now means entire genomes can be interrogated with a high degree of sensitivity, specificity and throughput.
Hamlet, S, Petcu, E, Ivanovski, S
openaire +3 more sources
Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine [PDF]
, 2019 Background: Mycobacterium bovis bacillus Calmette-Guerin (M. bovis BCG) is the only vaccine available against tuberculosis (TB). In an effort to standardize the vaccine production, three substrains, i.e. BCG Danish 1331, Tokyo 172-1 and Russia BCG-1 were
Borgers, Katlyn +9 more
core +2 more sources
Genomic Analysis in the Age of Human Genome Sequencing [PDF]
Cell, 2019 Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of human genomes as part of various gene ...
Tuuli, Lappalainen +3 more
openaire +2 more sources
Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancer
Molecular Systems Biology, 2012 The EGFR‐driven cell‐cycle pathway has been extensively studied due to its pivotal role in breast cancer proliferation and pathogenesis. Although several studies reported regulation of individual pathway components by microRNAs (miRNAs), little is known ...
Stefan Uhlmann +12 more
doaj +1 more source
Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]
, 2011 A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia +30 more
core +2 more sources