Results 41 to 50 of about 2,661,224 (296)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

Nature Communications, 2022
This paper proposed a novel in-silico framework for automatically screening disease-related variants and applied it to over 200,000 transcriptomes, providing an example to acquire medically relevant knowledge from publicly available sequence data.
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raúl Nicolás Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi   +9 more
doaj   +1 more source

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources

Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics

BMC Genetics, 2020
Background In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and ...
Yue Hu, Yihe Zhang, Cong Liu, Rui Qin, Desheng Gong, Ru Wang, Du Zhang, Lianqiang Che, Daiwen Chen, Guizhong Xin, Fei Gao, Qi Hu   +11 more
doaj   +1 more source

Adaptive estimation for Hawkes processes; application to genome analysis [PDF]

, 2010
The aim of this paper is to provide a new method for the detection of either favored or avoided distances between genomic events along DNA sequences. These events are modeled by a Hawkes process.
Reynaud-Bouret, Patricia, Schbath, Sophie   +1 more
core   +6 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Exploring the loblolly pine (Pinus taeda L.) genome by BAC sequencing and Cot analysis. [PDF]

, 2018
Loblolly pine (LP; Pinus taeda L.) is an economically and ecologically important tree in the southeastern U.S. To advance understanding of the loblolly pine (LP; Pinus taeda L.) genome, we sequenced and analyzed 100 BAC clones and performed a Cot ...
Arick, Mark, Chouvarine, Philippe, Dean, Jeffrey FD, Grimwood, Jane, Magbanua, Zenaida V, Mukherjee, Dipaloke, Nairn, Campbell J, Perera, Dinum, Peterson, Daniel G, Schmutz, Jeremy, Thummasuwan, Supaphan   +10 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters

Frontiers in Genetics, 2019
Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma biomarkers, hepatic metabolites, transcripts, and single nucleotide polymorphism (SNP) genotypes of
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Karen Methling, Michael Lalk, Eduard Murani, Klaus Wimmers, Klaus Wimmers   +7 more
doaj   +1 more source

Deciphering the genome structure and paleohistory of _Theobroma cacao_ [PDF]

, 2010
We sequenced and assembled the genome of _Theobroma cacao_, an economically important tropical fruit tree crop that is the source of chocolate. The assembly corresponds to 76% of the estimated genome size and contains almost all previously described ...
Angé, Ange Marie Risterucci, Anne Dievart, Auré, Bertrand Pitollat, Christopher Viot, Claire Lanaud, Cristian Chaparro, Dave Kudrna, Didier Clement, Diogenes Infante, Dominique Brunel, Emmanuel Guiderdoni, Erika Sallet, Florent Murat, Francis Quetier, Francois Sabot, Gaetan Droc, Ismael Kebe, Jean Marc Aury, Jerome Gouzy, Jerome Salse, Jetty Siva S. Ammiraju, John E. Carlson, Jose Fernandes Barbosa-Neto, Joseph Moroh Akaza, Julie Poulain, Karina Gramacho, Laura Gelley, Maguy Rodier-Goud, Manuel Ruiz, Mark Guiltinan, Mathias Tahi, Mathilde Allegre, Melissa Kramer, Michael Abrouk, Michael Axtell, Michel Boccara, Mickael Bourge, Olivier Fouet, Olivier Panaud, Patrick Wincker, Pierre Costet, Rod Wing, Ronan Rivalan, Schiex T., Siela Maximova, Spencer Brown, Stephan C. Schuster, Stephanie Sidibe-Bocs, Thierry Legavre, Valentin Guignon, W. Richard McCombie, Wolfgang Golser, Xavier Argout, Xavier Sabau, Xiang Song, Yolande Roguet, Yufan Zhang, Zhaorong Ma, Zi Sh   +60 more
core   +2 more sources