Results 61 to 70 of about 25,229,043 (255)

Genome sequence of the pea aphid Acyrthosiphon pisum [PDF]

open access: yes, 2010
Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity.
Fenton, Brian   +788 more
core   +1 more source

Leveraging the Assembly of the Durum Wheat Genome cv. Svevo

open access: yes, 2017
Tetraploid wheat species, with his two wild and cultivated subspecies T. turgidum ssp. dicoccoides and ssp. durum, is a cornerstone of the wheat polyploidy complex.
The International Durum Wheat Sequencing Consortium   +3 more
core   +1 more source

TGFβ1 regulates HGF‐induced cell migration and hepatocyte growth factor receptor MET expression via C‐ets‐1 and miR‐128‐3p in basal‐like breast cancer

open access: yesMolecular Oncology, 2018
Breast cancer is the most common cancer in women worldwide. The tumor microenvironment contributes to tumor progression by inducing cell dissemination from the primary tumor and metastasis.
Christian Breunig   +11 more
doaj   +1 more source

Subcellular protein extraction from human pancreatic cancer tissues

open access: yesBioTechniques, 2009
Proteins are the major class of effector molecules in cellular systems. For the identification of functional differences between normal and diseased tissues, a reliable analysis of their protein content is essential.
Anette Börner   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Analysis of Bulk RNA Sequencing Data Reveals Novel Transcription Factors Associated With Immune Infiltration Among Multiple Cancers

open access: yesFrontiers in Immunology, 2021
Tumor-infiltrating immune cells shape the tumor microenvironment and are closely related to clinical outcomes. Several transcription factors (TFs) have also been reported to regulate the antitumor activity and immune cell infiltration.
Lei Liu   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The complexity of Rhipicephalus (Boophilus) microplus genome characterised through detailed analysis of two BAC clones [PDF]

open access: yes, 2011
Background Rhipicephalus (Boophilus) microplus (Rmi) a major cattle ectoparasite and tick borne disease vector, impacts on animal welfare and industry productivity.
Peterson, D.   +45 more
core   +2 more sources

Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness

open access: yesBMC Biology
Background Breast cancer is the leading cause of cancer-related mortality in women. Deregulation of miRNAs is frequently observed in breast cancer and affects tumor biology.
Oyku Ece Sumer   +17 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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