Results 71 to 80 of about 28,777,576 (349)

Microbial genome analysis: the COG approach

Briefings Bioinform., 2019
For the past 20 years, the Clusters of Orthologous Genes (COG) database had been a popular tool for microbial genome annotation and comparative genomics.
Michael Y. Galperin, D. Kristensen, K. Makarova, Y. Wolf, E. Koonin   +4 more
semanticscholar   +1 more source

Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment

Microbiome, 2017
Background Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C.
Sepideh Pakpour, Amit Bhanvadia, Roger Zhu, Abhimanyu Amarnani, Sean M. Gibbons, Thomas Gurry, Eric J. Alm, Laura A. Martello   +7 more
doaj   +1 more source

Privacy in the Genomic Era [PDF]

, 2015
Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including personalized ...
Ayday, Erman, Clayton, Ellen W., Fellay, Jacques, Gunter, Carl A., Hubaux, Jean-Pierre, Malin, Bradley A., Naveed, Muhammad, Wang, XiaoFeng   +7 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

Nature Communications, 2022
This paper proposed a novel in-silico framework for automatically screening disease-related variants and applied it to over 200,000 transcriptomes, providing an example to acquire medically relevant knowledge from publicly available sequence data.
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raúl Nicolás Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi   +9 more
doaj   +1 more source

Exploring the loblolly pine (Pinus taeda L.) genome by BAC sequencing and Cot analysis. [PDF]

, 2018
Loblolly pine (LP; Pinus taeda L.) is an economically and ecologically important tree in the southeastern U.S. To advance understanding of the loblolly pine (LP; Pinus taeda L.) genome, we sequenced and analyzed 100 BAC clones and performed a Cot ...
Arick, Mark, Chouvarine, Philippe, Dean, Jeffrey FD, Grimwood, Jane, Magbanua, Zenaida V, Mukherjee, Dipaloke, Nairn, Campbell J, Perera, Dinum, Peterson, Daniel G, Schmutz, Jeremy, Thummasuwan, Supaphan   +10 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics

BMC Genetics, 2020
Background In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and ...
Yue Hu, Yihe Zhang, Cong Liu, Rui Qin, Desheng Gong, Ru Wang, Du Zhang, Lianqiang Che, Daiwen Chen, Guizhong Xin, Fei Gao, Qi Hu   +11 more
doaj   +1 more source

Deciphering the genome structure and paleohistory of _Theobroma cacao_ [PDF]

, 2010
We sequenced and assembled the genome of _Theobroma cacao_, an economically important tropical fruit tree crop that is the source of chocolate. The assembly corresponds to 76% of the estimated genome size and contains almost all previously described ...
Angé, Ange Marie Risterucci, Anne Dievart, Auré, Bertrand Pitollat, Christopher Viot, Claire Lanaud, Cristian Chaparro, Dave Kudrna, Didier Clement, Diogenes Infante, Dominique Brunel, Emmanuel Guiderdoni, Erika Sallet, Florent Murat, Francis Quetier, Francois Sabot, Gaetan Droc, Ismael Kebe, Jean Marc Aury, Jerome Gouzy, Jerome Salse, Jetty Siva S. Ammiraju, John E. Carlson, Jose Fernandes Barbosa-Neto, Joseph Moroh Akaza, Julie Poulain, Karina Gramacho, Laura Gelley, Maguy Rodier-Goud, Manuel Ruiz, Mark Guiltinan, Mathias Tahi, Mathilde Allegre, Melissa Kramer, Michael Abrouk, Michael Axtell, Michel Boccara, Mickael Bourge, Olivier Fouet, Olivier Panaud, Patrick Wincker, Pierre Costet, Rod Wing, Ronan Rivalan, Schiex T., Siela Maximova, Spencer Brown, Stephan C. Schuster, Stephanie Sidibe-Bocs, Thierry Legavre, Valentin Guignon, W. Richard McCombie, Wolfgang Golser, Xavier Argout, Xavier Sabau, Xiang Song, Yolande Roguet, Yufan Zhang, Zhaorong Ma, Zi Sh   +60 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source