Results 81 to 90 of about 25,229,043 (255)

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) [PDF]

, 2010
Background The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies.
Finlay Emma K., Park Stephen D. E., Daniel G Bradley, Shapiro Beth, Edwards Ceiridwen J., Ceiridwen J Edwards, Murphy, A., MacHugh David E., Beth Shapiro, Edwards, C.J., Bradley Daniel G., Park, S.D.E., MacHugh, D.E., McGettigan, Paul A., Shapiro, Beth, Alison Murphy, Martin B Richards, Chamberlain Andrew T., Loftus Brendan J., Murphy, Alison, Bradley, D.G., Knapp, Michael, David A Magee, Amanda J Lohan, Magee David A., Stephen D E Park, Lohan, A.J., Shapiro, B., Magee, David A., Bradley, Daniel G., Brendan J Loftus, Richards Martin B., Richards, M.B., Paul A McGettigan, Loftus, Brendan J., Park, Stephen D E, David E MacHugh, Chamberlain, Andrew T., Murphy Alison, MacHugh, David E., Andrew T Chamberlain, Park, Stephen D. E., Lohan, Amanda J., Lohan Amanda J., Loftus, B.J., Finlay, Emma K., McGettigan, P.A., Finlay, E.K., Richards, Martin B., Magee, D.A., Emma K Finlay, McGettigan Paul A., Chamberlain, A.T., Edwards, Ceiridwen J., Magee, David A, Finlay, Emma K, Machugh, David E, Lohan, Amanda J, Chamberlain, Andrew T, Richards, Martin B, McGettigan, Paul A, Edwards, Ceiridwen J, Bradley, Daniel G, Loftus, Brendan J   +63 more
core   +1 more source

Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs

Frontiers in Genetics, 2019
The pig (Sus scrofa) is not only an important livestock animal but also widely used as a biomedical model. However, the understanding of the molecular characteristics of organs and of the developmental skeletal muscle of the pig is severely limited. Here,
Muya Chen, Muya Chen, Yi Long Yao, Yi Long Yao, Yalan Yang, Yalan Yang, Min Zhu, Min Zhu, Yijie Tang, Yijie Tang, Siyuan Liu, Siyuan Liu, Kui Li, Zhonglin Tang, Zhonglin Tang, Zhonglin Tang   +15 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Genome-wide significant meta-analysis results for five traits.

, 2016
Genome-wide significant meta-analysis results for five traits.
Richard A. Spritz (256023), Nichole L. Nidey (3080523), Jeffrey C. Murray (134603), Ekaterina Orlova (3080541), Michael L. Cunningham (200464), Seth M. Weinberg (435939), Zachary D. Raffensperger (3080517), Chung How Kau (3080526), Mary L. Marazita (134605), Ophir Klein (163622), Elizabeth J. Leslie (546860), Benedikt Hallgrimsson (259772), George L. Wehby (534873), John R. Shaffer (206255), Cecelia A. Laurie (3080538), Carrie L. Heike (3080520), Cathy C. Laurie (110245), Tracey Ferrara (2310391), Myoung Keun Lee (3080544), Eleanor Feingold (10018), Lina M. Moreno (3080535), Washington Mio (655721), Joanne Cole (3080532), Stephanie Santorico (3080529), Jacqueline T. Hecht (365415)   +24 more
core   +1 more source

SST gene hypermethylation acts as a pan‐cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood‐based diagnosis

Molecular Oncology, 2020
Aberrant DNA methylation is often involved in carcinogenesis. Our initial goal was to identify DNA methylation biomarkers associated with pancreatic cancer.
Mehdi Manoochehri, Yenan Wu, Nathalia A. Giese, Oliver Strobel, Stefanie Kutschmann, Florian Haller, Jörg D. Hoheisel, Evgeny A. Moskalev, Thilo Hackert, Andrea S. Bauer   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

DNA methylation analysis of porcine mammary epithelial cells reveals differentially methylated loci associated with immune response against Escherichia coli challenge

BMC Genomics, 2019
Background Epigenetic changes such as cytosine (CpG) DNA methylations regulate gene expression patterns in response to environmental cues including infections.
Basavaraj Sajjanar, Nares Trakooljul, Klaus Wimmers, Siriluck Ponsuksili   +3 more
doaj   +1 more source