Results 91 to 100 of about 25,229,043 (255)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M., Eriko Takano (50986), Breitling, Rainer, Albert Gevorgyan, Gevorgyan, A., Breitling, R., Andrzej M Kierzek, Zakrzewski, Piotr, Breitling Rainer, Gevorgyan Albert, Piotr Zakrzewski (111739), Piotr Zakrzewski, Rainer Breitling (4371), Eriko Takano, Medema, M.H., Zakrzewski Piotr, Gevorgyan, Albert, Takano Eriko, Kierzek, Andrzej M., Zakrzewski, P., Takano, E., Rainer Breitling, Medema Marnix H., Marnix H. Medema (111741), Medema, Marnix H., Albert Gevorgyan (111745), Andrzej M. Kierzek (111748), Kierzek Andrzej M., Takano, Eriko, Marnix H Medema, Takano, Eriko; id_orcid, Breitling, R, Medema, MH, Kierzek, AM, Zakrzewski, P, Gevorgyan, A, Takano, E, Breitling, Rainer; id_orcid   +37 more
core   +2 more sources

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

BMC Cancer, 2019
Background Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src ...
Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu, Yi Zhang   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

In situ, Cell-free Protein Expression on Microarrays and Their Use for the Detection of Immune Responses

Bio-Protocol, 2019
Until recently, whole-proteome microarrays for comprehensive studies of protein interactions were mostly produced by individual cloning and cellular expression of very many open reading frames, followed by protein isolation and purification as well as ...
Katrin Hufnagel, Dennis Reininger, Siu Ng, Nadine Gassert, Juliane Rohland, Soroosh Shahryarhesami, Andrea Bauer, Tim Waterboer, Jörg Hoheisel   +8 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Genome-wide association study summary data of 10,000 single nucleotide polymorphisms from a squamous cell carcinoma meta-analysis

, 2020
This dataset consists of a single spreadsheet in .txt format. The data are genome-wide association study (GWAS) data relating to 10,000 single nucleotide polymorphisms (SNPs) from a squamous cell carcinoma (SCC) meta-analysis.
Andre Uitterlinden (3508127), Kristin Thorisdottir (8297749), Jon H. Olafsson (8297745), Luba M. Pardo (3636970), Yuan Lin (79040), Kavita Y. Sarin (3605282), Roxana Daneshjou (107092), Jiali Han (152479), Paul Khavari (3552722), Alice Whitemore (8297754), Andrey Ziyatdinov (527850), Maryam M. Asgari (8297758), Simon N. Stacey (8297757), Eric Jorgensen (8297751), Gudmar Thorleifsson (156887), Tamar Nijsten (3636967), Bardur Sigurgeirsson (8297746), Amanda E. Toland (8297742), Kari Stefansson (26484), Peter Kraft (15118), 23andMe Research Team (8297756), Adam Rubin (3552728), Wenting Wu (174490)   +22 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Draft Genome Sequence of Marinobacter sp. Strain P4B1, an Electrogenic Perchlorate-Reducing Strain Isolated from a Long-Term Mixed Enrichment Culture of Marine Bacteria

, 2016
The perchlorate-reducing strain Marinobacter sp. strain P4B1 was isolated from a long-term perchlorate-degrading enrichment culture seeded with marine sediment. The draft genome of Marinobacter sp. P4B1 is comprised of the bacterial chromosome (3.60 Mbp,
Roberts, Deborah J., Xiao, Yeyuan, Fox, George E., Stepanov, Victor G., Lopez, April J.   +4 more
core   +1 more source

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype [PDF]

, 2009
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a
Clarke, L., Molyneux, M., Molyneux, Malcolm, Gordon, M. A., Kariuki, Samuel, Cormican, M., Parkhill, J, Thomson, N., Kingsley, Robert, Harris, D., Whitehead, Sally, Heyderman, R., Kariuki, S., Thomson, N. R., Whitehead, S., Achtman, Mark, Sangal, V, Molyneux, ME, Msefula, CL, Sangal, V., Marsh, K., Holt, K. E., Kariuki, S, MacLennan, Calman, Clarke, L, Achtman, M., MacLennan, C. A., Holt, Kathryn, Gordon, M., Heyderman, R. S., Dougan, G., Gordon, Melita, Sangal, Vartul, Holt, K., Msefula, C., Msefula, Chisomo, Cormican, Martin, Holt, KE, Parkhill, J., Kingsley, R., Msefula, C. L., Marsh, K, Kingsley, RA, Dougan, Gordon, Kingsley, R. A., Parkhill, Julian, Gordon, MA, Thomson, Nicholas, Whitehead, S, Harris, D, Molyneux, M. E., Heyderman, RS, Harris, David, Marsh, Kevin, MacLennan, C., Clarke, Louise, Dougan, G, Heyderman, Robert, Thomson, NR, Achtman, M, Cormican, M   +60 more
core   +1 more source