Results 51 to 60 of about 25,229,043 (255)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-wide analysis of local chromatin packing in Arabidopsis thaliana

, 2019
Hi-C maps (2 kb bin: chromosomal; 20 kb bin: genome-wide) of Arabidopsis thaliana (Col-0).These Hi-C maps were used for analyzing chromatin organization patterns presented in:Congmao Wang, Chang Liu, Damian Roqueiro, Dominik Grimm, Rebecca Schwab, Claude
Chang Liu (6570488)
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]

, 2014
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.
Herrington, D.M., Postmus, Iris, Trompet, S., Ridker, P.M., O'Donnell, C.J. (Christopher J.), Ballantyne, C. (Christie), Liu, YM, Kastelein, JJP, Rivadeneira Ramirez, F. (Fernando), Pearson, Richard, Arnold, A.M. (Alice), O???donnell, Christopher J., Palmer, Colin N.A., Boerwinkle, E., Wei, W.-Q. (Wei-Qi), Barnes, M.R., Viswanathan, Ananth C., Potter, S.C. (Simon), Arnold, A.M., Caulfield, M. (Mark), Groop, L, Viswanathan, A.C. (Ananth), McKeigue, Paul M., Eiriksdottir, Gudny, Pirinen, M. (Matti), Palmer, Colin N. A., Barratt, BJ, Edkins, Sarah, Waller, Matthew, Smith, AV, Whitsel, E.A. (Eric), de Keyser, Catherine E., Buckley, BM, Arsenault, B.J. (Benoit J.), Whitsel, E.A., Hammond, Naomi, Sever, P, Franco Duran, OH, Liu, Y, Corvin, A. (Aiden), Palmer, CN, Barratt, B.J., Liu, Ching-Ti, Kastelein, J.J.P. (John), Groop, L., de Keyser, Toke, Zhou, Kaixin, Ford, I, Trompet, S. (Stella), Su, Zhan, Boerwinkle, Eric, Chu, A.Y., Sotoodehnia, Nona, Franco, O.H., Band, G. (Gavin), Wiggins, Kerri L., Eiriksdottir, G, O'Donnell, CJ, Boerwinkle, E, Uitterlinden, AG, Potter, Simon C., Heckbert, Susan R, Feng, Q. (Qiping), Hofman, A., Bis, JC, Krauss, Ronald M., Nickerson, D.A. (Deborah), Harris, T.B. (Tamara), Evans, DS, Palmer, C.N.A. (Colin), Blackburn, H. (Hannah), Stanton, A. (Alice), Wood, N.W. (Nicholas), Tardif, J-C, Wiggins, K.L. (Kerri), Johnson, A.D. (Andrew), Giulianini, F., Jukema, JW, Kritchevsky, S.B., Munroe, PB, Pierre Dubé, Marie, Cupples, L.A. (Adrienne), Blackwell, K.L. (Kimberly), Griffin, P., Keyser, C.E. de, Pirinen, Matti, Morris, A., Sattar, N, Rivadeneira, F, Griffin, P. (Paula), Shields, Denis C., Herrington, DM, Hellenthal, Garrett, Plomin, R. (Robert), Stafford, J.M. (Jeanette M.), Bellenguez, C??line, Betteridge, J, Shields, D.C., Widaa, S. (Sara), Stürmer, Til, Hitman, G, Wiggins, K.L., Bumpstead, Suzannah J., Hovingh, G.K., Neil, A. (Andrew), Tardif, J.-C. (Jean-Claude), Lumley, T., O'Brien, E. (Eoin), Munroe, P. (Patricia), ?, ?, de Craen, AJM, Liu, C-T, Wiggins, KL, Ford, Ian, De Craen, AJ, O’Donnell, Christopher J., Stafford, Jeanette M., Sotoodehnia, N. (Nona), McCarthy, MI, Bramon, E. (Elvira), Slagboom, PE, Casas, J.P. (Juan), Neil, Andrew, MacFadyen, J.G. (Jean G.), Shields, D.C. (Denis C.), Taylor, KD, Doney, A., Wei, Wei-Qi, Adrienne Cupples, L, Wilke, RA, Taylor, K.D., Strange, A. (Amy), Spencer, Chris C.A., McCann, O.T. (Owen), Morris, Andrew, Welcome Trust Case Control Consort, Postmus, D. (Douwe), Emilsson, V., Freeman, Colin, Launer, L.J., Guo, Xiuqing, Spencer, Chris C. A., Avery, C.L., Cupples, L.A., Rice, Kenneth, Krauss, RM, Gray, Emma, Chasman, Daniel I., Sever, P. (Peter), Caulfield, M.J., Li, G. (Guo), O'Brien, Eoin, Franco, OH, Gudnason, V. (Vilmundur), other, and, Sotoodehnia, N, Nickerson, D.A., Jayakumar, A. (Alagurevathi), Boekholdt, S.M., Chu, AY, Uitterlinden, Andr?? G., Wilke, R.A. (Russell A.), Doney, Alex; id_orcid, Li, XH, Sun, FG, Colhoun, HM, MacFadyen, J.G., Chasman, Daniel, Avery, CL, Rice, K., Betteridge, John, Carr, F, Durrington, P.N. (Paul), Ngwa, JS, Buckley, B.M., Post, Wendy, Deshmukh, H.A., Herrington, D.M. (David), Liu, C.-T. (Ching-Ti), Giulianini, F. (Franco), Munroe, Patricia B., Hammond, N. (Naomi), Uitterlinden, A.G. (André), Ahlqvist, E. (Emma), Ridker, PM, Jukema, J.W., Widaa, Sara, Betteridge, J., Duncanson, A. (Audrey), Ding, JZ (Jing Zhong), Adrienne Cupples, L., Sever, Peter, Poulter, N, Zhou, K. (Kaixin), Ballantyne, C.M., Matthijs Boekholdt, S., Carr, F., Liu, CT, Stott, D.J. (David. J.), Slagboom, P.E., Morris, A.D. (Andrew), Buckley, Brendan M., Mathew, C.G. (Christopher G.), Stanton, A, Gudnason, V, Li, Xiaohui, Shaw-Hawkins, S. (Sue), O???brien, Eoin, Ding, Jingzhong, Uitterlinden, André G., Cupples, LA, Nyberg, F, Mathew, Christopher G., Wellcome Trust Case Control Consortium, Warren, Helen R., Wei, WQ, Chu, A.Y. (Audrey), Warren, H.R., Stott, D.J., Smith, Albert V., Barratt, B.J. (Bryan J.), Westendorp, Rudi G. J., Vasan, Ramachandran S., Bramon, Elvira, Plomin, Robert, Nyberg, F. (Fredrik), Hellenthal, F.A., McCarthy, M.I., Tardif, Jean-Claude, Sawcer, S.J. (Stephen), Pierre Dub??, Marie, Chen, Y-DI, Munroe, P.B., Band, Gavin, Tardif, JC, Rotter, J.I., Post, W. (Wendy), Groop, L. (Leif), Wilke, R.A., Trompet, Stella, Psaty, B.M. (Bruce), Harris, TB, Casas, Juan P., Keyser, C.E. (Catherina Elisabeth) de, Stafford, JM, Deloukas, Panos, Li, X. (Xiaohui), Herrington, David M., Neil, A, Brown, Matthew, Ida Chen, Y.-D., Bellenguez, C. (Céline), Li, Guo, Barroso, Ines, Sun, F. (Fangui), McKeigue, P.M., Launer, Leonore J., Guo, XQ, Lumley, Thomas, Kastelein, John J. P., Chu, Audrey Y., Smith, Nicholas L., Smith, A.V. (Davey), Hofman, Albert, Donnelly, L.A. (Louise), Palmer, CNA, Barnes, M.J. (Michael), Doney, A, Tardif, J.C., Postmus, I, Shaw-Hawkins, S, de Craen, Anton J. M., Stricker, Bruno H., Poulter, N.R. (Neil), Stanton, A., Liddle, J. (Jennifer), Avery, Christy L., Vasan, R.S., Su, Z. (Zhan), Barroso, I.E. (Inês), Ding, J, Colhoun, H.M. (H.), Ngwa, Julius S., Ahlqvist, E, Corvin, Aiden, Rotter, J.I. (Jerome I.), Johnson, Andrew D., Rotter, JI, Ricketts, M. (Michelle), McCarthy, M.I. (Mark), Ahlqvist, Emma, Franco, O.H. (Oscar), Trembath, R.C. (Richard), Ballantyne, Christie M., Sotoodehnia, N., Psaty, Bruce M., Wei, W-Q, Carr, Fiona, Hitman, G.A. (Graham), Liu, C.T., Feng, Q, Barnes, Michael, Smith, N.L., Caulfield, Mark J., Westendorp, RGJ, MacFadyen, Jean G., Doney, Alex, Boekholdt, SM, Gudnason, V., Deshmukh, HA, Slagboom, P.E. (Eline), Boekholdt, S.M. (Matthijs), Freeman, C. (Colin), Neil, A., Stricker, Bruno, Barnes, Michael R., Liddle, Jennifer, Whittaker, Pamela, Bis, J.C. (Joshua), Ngwa, J.S., Chasman, D.I. (Daniel), Gwilliam, R. (Rhian), Durrington, Paul N., Hofman, Bert, Denny, J.C. (Joshua C.), Jukema, J. Wouter, Johnson, A.D., Trembath, Richard, Rautanen, A. (Anna), Liu, Y. (YongMei), Mathew, Christopher G.; id_orcid, Jankowski, J.A. (Janusz Antoni), Donnelly, LA, Gwilliam, Rhian, Palmer, C.N.A., Wood, Nicholas W., Heckbert, SR, Bellenguez, Céline, Sattar, Naveed, Giannoulatou, E. (Eleni), Stott, David J., Lumley, T, Franco, Oscar H., Durrington, P.N., Deshmukh, Harshal A., Whitsel, EA, Ahlqvist, E., Waller, M. (Matthew), Smith, A.V., Heckbert, S.R. (Susan), Blackwell, Jenefer M., Kritchevsky, SB, Craen, A.J. (Anton) de, Mckeigue, P.M. (Paul), Chasman, DI, Bumpstead, S. (Suzannah), Dube, M.P., Feng, QiPing, Guo, X.Q., Slagboom, P. Eline, Stuermer, T, Rivadeneira, Fernando, Brown, M.A. (Matthew), Stricker, B.H.Ch. (Bruno), Edkins, T. (Ted), Blackburn, Hannah, Eiriksdottir, G. (Gudny), Smith, N.L. (Nicholas), Bis, J.C., Ravindrarajah, Radhi, Harris, T.B., Smith, J.D. (Joshua D.), Rice, K.M. (Kenneth), Barnes, MR, Wilke, Russell A., Hitman, G., Feng, QP, McCann, Owen T., Ding, J.Z., Sawcer, Stephen J., Vukcevic, D. (Damjan), Jukema, J.W. (Jan Wouter), Wouter Jukema, J, Liu, Y.M., Hitman, Graham, Strange, Amy, Li, G, Hunt, S.E. (Sarah), Eline Slagboom, P., Ding, J. (Jingzhong), Langford, C. (Cordelia), St??rmer, Til, Langford, Cordelia, Stricker, B.H., Shaw-Hawkins, S., Kastelein, JJ, Donnelly, P. (Peter), Evans, Daniel S., Deshmukh, H. (Harshal), Betteridge, J. (John), Boerwinkle, E.A. (Eric), Eiriksdottir, G., Westendorp, R.G.J., Johnson, AD, Bis, Joshua C., McCarthy, Mark I., Denny, Joshua C., Dronov, Serge, Emilsson, V. (Valur), Harris, Tamara B., Li, X, Westendorp, R.G.J. (Rudi), Warren, HR, Giulianini, Franco, Guo, X. (Xiuqing), Emilsson, Valur, Heckbert, S.R., Weston, P. (Paul), Chen, Y.D.I., Kastelein, J.J.P., Launer, LJ (Lenore), Gudnason, Vilmundur, Dronov, S. (Serge), Post, W., Vasan, RS, Poulter, Neil, Chen, YDI, Uitterlinden, André; id_orcid, Sever, P., Rivadeneira, F., Liu, Yongmei, Stanton, Alice, Kastelein, John J.P., Sattar, N. (Naveed), Gillman, M. (Matthew), Craen, A.J.M. de, Donnelly, Peter, de Craen, Anton J.M., Shaw-Hawkins, Sue, Arsenault, BJ, Postmus, I., Durrington, PN, Griffin, P, Smith, Joshua D., Smith, JD, Rice, K, Dubé, G.P. (Gregory), Spencer, C.C.A. (Chris C.), Zhou, KX, Hovingh, G.K. (Kees), O’Brien, Eoin, Gillman, Matthew, Nickerson, DA, Arsenault, B.J., Donnelly, L.A., O'Donnell, C.J., Trembath, Richard C., Warren, H. (Helen), O'Brien, E., Hofman, A. (Albert), Denny, JC, Post, W, Sattar, N., Taylor, Kent D., Ford, I., Vukcevic, Damjan, Stürmer, T., Poulter, N., Caulfield, MJ, Guo, X, Weston, Paul, Whitsel, Eric A., Colhoun, Helen M., Donnelly, Louise A., Uitterlinden, A.G., Stott, DJ, Doney, A.S.F. (Alex), Rautanen, Anna, Buckley, B.M. (Brendan M.), Deshmukh, Harshal, Jankowski, Janusz, Colhoun, H.M., Ridker, P.M. (Paul), Nyberg, Fredrik, Vasan, R.S. (Ramachandran Srini), Emilsson, V, Krauss, R.M. (Ronald), Feng, Q.P., Arnold, Alice M., Brown, Matthew A., Psaty, BM, Arsenault, Benoit J., Zhou, K, Whittaker, P. (Pamela), Westendorp, RG, Sun, Fangui, Chen, YD, Slagboom, PE (Eline), Smith, J.D., Kritchevsky, Stephen B., Consort, WTCC, Nickerson, Deborah A., Evans, D.S. (Daniel), Smith, NL, Chen, Y.-D.I. (Ida), Taylor, K.D. (Kent), Stafford, J.M., Psaty, B.M., Griffin, Paula, Giannoulatou, Eleni, Hofman, A, Carr, F. (Fiona), Nyberg, F., Lumley, T. (Thomas), Giulianini, F, Duncanson, Audrey, Launer, L.J. (Lenore), Markus, Hugh S., Hovingh, GK, Trompet, S, Stricker, BH, Li, X.H., Ballantyne, CM, Launer, LJ, Chasman, D.I., Li, G., Kees Hovingh, G., Markus, H.S. (Hugh), Evans, D.S., Morris, A, Sun, F, Krauss, R.M., McKeigue, PM, Wei, W.Q., Jayakumar, Alagurevathi, Groop, Leif, Rotter, Jerome I., Ricketts, Michelle, Kritchevsky, S.B. (Stephen), Gray, E. (Emma), Ravindrarajah, R. (Radhi), Shields, DC, Deloukas, P. (Panagiotis), Pearson, R. (Ruth), Sun, F.G., Zhou, K.X., Denny, J.C., Hunt, Sarah E., Barratt, Bryan J., Ridker, Paul M., O'Brien, E, Arnold, AM, Palmer, Colin N. A.; id_orcid, Vasan, Ramachandran S, Harris, Tamara B, McCarthy, Mark I, Uitterlinden, André G, Nyberg, Fredrik,, Whitsel, Eric A, Palmer, Colin NA, Warren, Helen R, Smith, Albert V, Stricker, Bruno H, MacFadyen, Jean G, Chu, Audrey Y, McKeigue, Paul M, Kastelein, John JP, Chasman, Daniel I, Denny, Joshua C, Wiggins, Kerri L, Ballantyne, Christie M, Launer, Leonore J, Avery, Christy L, Franco, Oscar H, de Craen, Anton J M, Rotter, Jerome I, Barnes, Michael R, Durrington, Paul N, Lund University., de Keyser, Catherine E, Kastelein, John J P, Colhoun, Helen M, Kees Hovingh, G, Ngwa, Julius S, Buckley, Brendan M, Johnson, Andrew D, Ahlqvist, Emma,, Stafford, Jeanette M, Munroe, Patricia B, Evans, Daniel S, Bis, Joshua C, Smith, Joshua D, Stott, David J, Deshmukh, Harshal A, Psaty, Bruce M, Westendorp, Rudi G J, Groop, Leif,, Donnelly, Louise A, Ida Chen, Y-D, Arnold, Alice M, Ridker, Paul M, Palmer, Colin N A, Smith, Nicholas L, Herrington, David M, Matthijs Boekholdt, S, Barratt, Bryan J, O'Donnell, Christopher J, O’Donnell, Christopher J, de Craen, Anton JM, Eline Slagboom, P, Kritchevsky, Stephen B, Shields, Denis C, Krauss, Ronald M, Nickerson, Deborah A, Westendorp, Rudi GJ, Arsenault, Benoit J, Caulfield, Mark J, Wilke, Russell A, Taylor, Kent D, O'Donnell, CJ, O'Brien, E, Dube, MP, MacFadyen, JG, de Keyser, CE, Sturmer, T   +624 more
core   +1 more source

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081 [PDF]

, 2014
This work was supported by The Wellcome Trust.The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague.
Maddison, Mark, Abdellah, Zahra, Dougan, Gordon, Howard, Sarah, Quail, Michael A., Parkhill, Julian, Prentice, Michael B., Challis, Gregory L., Mungall, Karen, Chillingworth, Tracey, Moule, Sharon, Sanders, Mandy, Churcher, Carol, Thomson, Nicholas R., Wren, Brendan W., Whitehead, Sally, Brooks, Karen, Jagels, Kay, Feltwell, Theresa, Holden, Matthew T. G., Crossman, Lisa, Hauser, Heidi   +21 more
core   +4 more sources

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters

Frontiers in Genetics, 2019
Given the central metabolic role of the liver, hepatic metabolites and transcripts reflect the organismal physiological state. Biochemical-clinical plasma biomarkers, hepatic metabolites, transcripts, and single nucleotide polymorphism (SNP) genotypes of
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Karen Methling, Michael Lalk, Eduard Murani, Klaus Wimmers, Klaus Wimmers   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source