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The Future of Clinical Phage Therapy in the United Kingdom

Viruses, 2023
Bacteriophage (phage) therapy is a promising alternative antimicrobial strategy with the potential to transform the way bacterial infections are treated. In the United Kingdom, phages are classed as a biological medicine.
Joshua D. Jones, Clare Trippett, Mehrunisha Suleman, Martha R. J. Clokie, Jason R. Clark   +4 more
doaj   +2 more sources

A Comprehensive Review on Phage Therapy and Phage-Based Drug Development. [PDF]

Antibiotics (Basel)
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria.
Cui L, Watanabe S, Miyanaga K, Kiga K, Sasahara T, Aiba Y, Tan XE, Veeranarayanan S, Thitiananpakorn K, Nguyen HM, Wannigama DL.   +10 more
europepmc   +2 more sources

Perception of phage therapy and research across selected professional and social groups in Poland [PDF]

Frontiers in Public Health
There is no doubt that in the last 15 years phage therapy has re-emerged from the shadow of antibiotics, from the perspective of both scientists and various patient advocacy groups.
Maciej Żaczek, Marcin W. Zieliński, Andrzej Górski, Andrzej Górski, Andrzej Górski, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki   +8 more
doaj   +2 more sources

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

EMBO Molecular Medicine, 2019
Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced
Justyna Magdalena Przystal, Sajee Waramit, Md Zahidul Islam Pranjol, Wenqing Yan, Grace Chu, Aitthiphon Chongchai, Gargi Samarth, Nagore Gene Olaciregui, Ghazaleh Tabatabai, Angel Montero Carcaboso, Eric Ofori Aboagye, Keittisak Suwan, Amin Hajitou   +12 more
doaj   +2 more sources

Current challenges and future opportunities of phage therapy [PDF]

FEMS Microbiology Reviews, 2020
Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed.
Diana P. Pires, Ana Rita Costa, Graça Pinto, Luciana Meneses, Joana Azeredo   +4 more
openalex   +2 more sources

Mapping the tail fiber as the receptor binding protein responsible for differential host specificity of Pseudomonas aeruginosa bacteriophages PaP1 and JG004. [PDF]

, 2013
The first step in bacteriophage infection is recognition and binding to the host receptor, which is mediated by the phage receptor binding protein (RBP). Different RBPs can lead to differential host specificity.
He, Xuesong, Hu, Fuquan, Huang, Guangtao, Le, Shuai, Lux, Renate, Shi, Wenyuan, Tan, Yinling, Zhang, Lin   +7 more
core   +23 more sources

Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments

Frontiers in Pharmacology, 2021
Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Levan Pipia, Lia Nadareishvili, Dea Nizharadze   +5 more
doaj   +1 more source

Case report: Successful treatment of recurrent E. coli infection with bacteriophage therapy for patient suffering from chronic bacterial prostatitis

Frontiers in Pharmacology, 2023
Background: Chronic Bacterial Prostatitis (CBP) is inflammation of the prostate caused by bacterial infection. An estimated 8.2% of men have prostatitis, most commonly under the age of 50.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Naomi Hoyle, Lia Nadareishvili, Levan Pipia, Dea Nizharadze   +6 more
doaj   +1 more source

DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins

Frontiers in Microbiology, 2021
Introduction: Increasing number of deaths from multi-drug resistant bacterial infections has caused both the World Health Organization and the Centers for Disease Control and Prevention to repeatedly call for development of new, non-traditional ...
Marek Harhala, Marek Harhala, Katarzyna Gembara, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson, Krystyna Dąbrowska, Krystyna Dąbrowska   +11 more
doaj   +1 more source

Phage Therapy—Challenges, Opportunities and Future Prospects

Pharmaceuticals, 2023
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly.
Beata Zalewska-Piątek
semanticscholar   +1 more source