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The Potential of Phage Therapy in Sepsis [PDF]

Frontiers in Immunology, 2017
Sepsis remains a difficult clinical challenge, since our understanding of its immunopathology is incomplete and no efficacious treatment currently exists. Its earlier stage results from an uncontrolled inflammatory response to bacteria while in the later stage disturbed immune response with immunodeficiency syndrome develops.
Andrzej Górski, Ewa Jończyk‐Matysiak, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Beata Weber‐Dąbrowska, Jan Borysowski   +5 more
openalex   +4 more sources

Isolation and Characterization of Klebsiella Phages for Phage Therapy [PDF]

PHAGE, 2021
Introduction: Klebsiella is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection, and sepsis. Bacteriophage (phage) therapy is being considered a primary option for the treatment of drug-resistant infections of these types ...
Townsend, Eleanor M, Kelly, Lucy, Gannon, Lucy, Muscatt, George, Dunstan, Rhys, Michniewski, Slawomir, Sapkota, Hari, Kiljunen, Saija J, Kolsi, Anna, Skurnik, Mikael, Lithgow, Trevor, Millard, Andrew D, Jameson, Eleanor   +12 more
openaire   +3 more sources

Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments

Frontiers in Pharmacology, 2021
Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Levan Pipia, Lia Nadareishvili, Dea Nizharadze   +5 more
doaj   +1 more source

Case report: Successful treatment of recurrent E. coli infection with bacteriophage therapy for patient suffering from chronic bacterial prostatitis

Frontiers in Pharmacology, 2023
Background: Chronic Bacterial Prostatitis (CBP) is inflammation of the prostate caused by bacterial infection. An estimated 8.2% of men have prostatitis, most commonly under the age of 50.
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Naomi Hoyle, Lia Nadareishvili, Levan Pipia, Dea Nizharadze   +6 more
doaj   +1 more source

DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins

Frontiers in Microbiology, 2021
Introduction: Increasing number of deaths from multi-drug resistant bacterial infections has caused both the World Health Organization and the Centers for Disease Control and Prevention to repeatedly call for development of new, non-traditional ...
Marek Harhala, Marek Harhala, Katarzyna Gembara, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson, Krystyna Dąbrowska, Krystyna Dąbrowska   +11 more
doaj   +1 more source

Immunogenicity of Endolysin PlyC

Antibiotics, 2022
Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms.
Marek Adam Harhala, Katarzyna Gembara, Daniel C. Nelson, Paulina Miernikiewicz, Krystyna Dąbrowska   +4 more
doaj   +1 more source

Pulsed Blue Light and Phage Therapy: A Novel Synergistic Bactericide. [PDF]

Antibiotics (Basel)
Rimon A, Belin J, Yerushalmy O, Eavri Y, Shapochnikov A, Coppenhagen-Glazer S, Hazan R, Gavish L.   +7 more
europepmc   +3 more sources

Two Newly Isolated Enterobacter-Specific Bacteriophages: Biological Properties and Stability Studies

Viruses, 2022
In an era of antibiotic therapy crisis caused by spreading antimicrobial resistance, and when recurrent urinary tract infections constitute a serious social and medical problem, the isolation and complex characterization of phages with a potential ...
Martyna Cieślik, Marek Harhala, Filip Orwat, Krystyna Dąbrowska, Andrzej Górski, Ewa Jończyk-Matysiak   +5 more
doaj   +1 more source

Phage Therapy

WikiJournal of Medicine, 2021
Phage therapy refers to the use of bacteriophages (phages - bacterial viruses) as therapeutic agents against infectious bacterial diseases. This therapeutic approach emerged in the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the second world war.
Joana Azeredo, Jean-Paul Pirnay, Diana P. Pires, Mzia Kutateladze, Krystyna Dabrowska, Rob Lavigne, Bob Blasdel   +6 more
openaire   +2 more sources

A Thorough Synthesis of Phage Therapy Unit Activity in Poland—Its History, Milestones and International Recognition

Viruses, 2022
The year 2020 marked 15 years of the Phage Therapy Unit in Poland, the inception of which took place just one year after Poland’s accession to the European Union (2004).
Maciej Żaczek, Andrzej Górski, Beata Weber-Dąbrowska, Sławomir Letkiewicz, Wojciech Fortuna, Paweł Rogóż, Edyta Pasternak, Ryszard Międzybrodzki   +7 more
doaj   +1 more source