Results 141 to 150 of about 4,514,314 (397)
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source
Annals of Global Health, 2017 ObjectivesShigellosis is an acute infection of the intestine caused by bacteria in the genus 'Shigella' and also an important cause of diarrhea in developing countries.
Prabhurajeshwar C +2 more
doaj +1 more source
Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy [PDF]
, 2019 Bacterial resistance to antibiotics is a global public health concern. New treatments are needed to combat resistant strains, among which phage therapy is a promising option.
Domingo Calap, Pilar +1 more
core +1 more source
Phage therapy as a potential solution in the fight against AMR: obstacles and possible futures
Palgrave Communications, 2020 Phage therapy, the use of bacteriophage viruses to treat bacterial infections, has existed for more than a hundred years. However, the practice is struggling to develop, despite growing support over the past 15 years from researchers and doctors, who see
Charlotte Brives, Jessica Pourraz
semanticscholar +1 more source
Pharmacological limitations of phage therapy
Upsala Journal of Medical Sciences, 2019 Clinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic treatment.
openaire +5 more sources
Advanced Science, EarlyView.A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin +11 more
wiley +1 more source
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
Angewandte Chemie, EarlyView.The (HhH)2‐Fold is an ancient and ubiquitous nucleic acid‐binding domain. We demonstrate that this domain, which interacts with the minor groove of dsDNA, is functionally ambidextrous – that it can bind to dsDNA of either chirality. Moreover, binding of both chiral forms of dsDNA is mediated by an overlapping binding surface.
Orit Weil‐Ktorza +8 more
wiley +2 more sources
BMC Microbiology, 2018 Background Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic-resistant bacteria in clinics ...
Prasanth Manohar +2 more
doaj +1 more source
Effects of Noise on Ecological Invasion Processes: Bacteriophage-mediated Competition in Bacteria [PDF]
, 2006 Pathogen-mediated competition, through which an invasive species carrying and transmitting a pathogen can be a superior competitor to a more vulnerable resident species, is one of the principle driving forces influencing biodiversity in nature.
arxiv +1 more source
Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? [PDF]
, 2008 Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized.
Dimitrov, Dimiter S, Marks, James D
core +1 more source