Results 141 to 150 of about 4,525,509 (335)
VirusesThe increasing consumer demand for minimally processed foods (MPFs) has highlighted the need for innovative preservation methods that ensure both safety and quality.
Michał Wójcicki +3 more
doaj +1 more source
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Advanced Science, EarlyView.Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng +14 more
wiley +1 more source
Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices [PDF]
, 2002 Laura Sanz +6 more
openalex +1 more source
Advanced Science, EarlyView.Ultrasound‐mediated biotransfection through intracellular cavitation increases plasmid nuclear translocation and gene transfection efficiency by 284.7% and 131.6% in engineered bone marrow mesenchymal stem cells (BMSCs) compared to traditional ultrasound‐targeted microbubble destruction techniques. The maintained bone morphogenetic protein 2 expression
Zhili Xu +7 more
wiley +1 more source
, 2022 Phage Therapy, which uses bacteriophages to combat a bacterial infection, has been around since the 1920s but was overshadowed by the success of antibiotics. The rise in antibiotic resistance has regenerated curiosity into the potential of this practice.
openaire +2 more sources
Advanced Science, EarlyView.Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu +7 more
wiley +1 more source
Human Volunteers Receiving Escherichia coli Phage T4 Orally: a Safety Test of Phage Therapy [PDF]
, 2005 Anne Bruttin, Harald Brüssow
openalex +1 more source
AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering
Advanced Science, EarlyView.AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun +13 more
wiley +1 more source
Theranostic Toolbox for Neutrophil Functionalization
Advanced Science, EarlyView.Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain +11 more
wiley +1 more source