Results 161 to 170 of about 4,514,314 (397)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections

Virology Journal
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E.
Nedaa M. Ismael, Mohamed Azzam, Mohamed Abdelmoteleb, Ayman El-Shibiny   +3 more
doaj   +1 more source

Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29 [PDF]

, 2017
The complete genomes of two Vibrio cholerae bacteriophages of potential interest for cholera bacteriophage (phage) therapy were sequenced and annotated.
Ackermann, Altschul, Aziz, Bankevich, Comeau, Laslett, Lee, Nicolle, Punta, Schattner, Summer, Xu   +11 more
core   +1 more source

Phage therapy: From biological mechanisms to future directions

Cell, 2023
S. Strathdee, G. Hatfull, Vivek K. Mutalik, R. Schooley   +3 more
semanticscholar   +1 more source

Editorial: Phage Biology and Phage Therapy

Frontiers in Microbiology, 2022
Shuai Le, Xuesong He, Xuesong He, Yigang Tong   +3 more
openaire   +3 more sources

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity.

Clinical Infectious Diseases, 2020
BACKGROUND Prosthetic joint infection (PJI) is a potentially limb-threatening complication of total knee arthroplasty. Phage therapy is a promising strategy to manage such infections including those involving antibiotic-resistant microbes, and to target ...
E. Cano, Katherine M. Caflisch, P. Bollyky, Jonas D. Van Belleghem, Robin Patel, J. Fackler, M. Brownstein, Bri'Anna Horne, B. Biswas, M. Henry, Francisco Malagon, D. Lewallen, G. Suh   +12 more
semanticscholar   +1 more source

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression

Advanced Science, EarlyView.
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv, Xiang Zhao, Songsong Teng, Xinmeng Jin, Ying Zhou, Yueyang Sun, Hao Pei, Zuoqin Yan, Chunhui Ma   +8 more
wiley   +1 more source

Enhancement of wound healing via topical application of natural products: In vitro and in vivo evaluations

Arabian Journal of Chemistry, 2022
Intact skin is the first physical barrier against all microbial infections. Thus, in the cases of wounds, burns, and skin damage, bacteria can infect and invade the deeper layers of skin to the bloodstream and other organs leading to severe illnesses ...
Abdallah S. Abdelsattar, Salsabil Makky, Rana Nofal, Mariam Hebishy, Mona M. Agwa, Rania G. Aly, Mohamed Y. Abo El-Naga, Yehia A. Heikal, Mohamed S. Fayez, Nouran Rezk, Ayman El-Shibiny   +10 more
doaj  

On the persistence of lytic bacteriophages in vivo and its consequences for bacteriophage therapy [PDF]

arXiv, 2019
Bacteriophages are viruses infecting bacteria and archaea. Many phage species cause infections which lead to the certain death of the infected prokaryotic host cell and the release of a large batch of phage progeny, yet they have been able to stably coexist with their bacterial hosts over the eons in nature, as well as in the majority of laboratory ...
arxiv