Results 181 to 190 of about 114,190 (344)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR‐Cas9‐based genome editing

mLife, EarlyView.
Abstract The CRISPR‐Cas9 system has been proven to be a powerful tool for gene editing in living cells and shows great potential in genetic disease treatment. Anti‐CRISPR (Acr)‐based optogenetic tools could spatiotemporally regulate the activity of CRISPR‐Cas9, thereby improving the precision and safety of gene editing.
Qi Chen, Jia Yao, Yingfan Lu, Ruikang Qiu, Zixin Deng, Yuhui Sun   +5 more
wiley   +1 more source

Listeria monocytogenes—Can We Reduce or Eliminate It From Food Commodities?

Molecular Nutrition &Food Research, EarlyView.
Listeria monocytogenes is a foodborne pathogen responsible for listeriosis. Traditional control methods include heat treatment, high‐pressure processing, irradiation, and acidification, all aimed at reducing bacterial load in foods. Emerging strategies include gene expression, CRISPR‐Cas9, bacteriophage, competitive exclusion via beneficial microbes ...
Loredana d'Ovidio, Débora Preceliano de Oliveira, Iskra Vitanova Ivanova, Manuela Vaz‐Velho, Bernadette Dora Gombossy de Melo Franco, Svetoslav Dimitrov Todorov   +5 more
wiley   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander, Océane M. Follonier, Andriy Kryshtafovych, Kim Abesamis, Sabrina Bibi‐Triki, Henry G. Box, Cécile Breyton, Françoise Bringel, Loic Carrique, Alessio d'Acapito, Gang Dong, Rebecca DuBois, Deborah Fass, Juliana Martinez Fiesco, Daniel R. Fox, Jonathan M. Grimes, Rhys Grinter, Matthew Jenkins, Roman Kamyshinsky, Jeremy R. Keown, Gerald Lackner, Michael Lammers, Shiheng Liu, Andrew L. Lovering, Tomas Malinauskas, Benoît Masquida, Gottfried J. Palm, Christian Siebold, Tiantian Su, Ping Zhang, Z. Hong Zhou, Krzysztof Fidelis, Maya Topf, John Moult, Torsten Schwede   +34 more
wiley   +1 more source

Phage Therapy

Canadian Young Scientist Journal, 2014
Mikael Skurnik, Saija Kiljunen, Maria Pajunen   +2 more
openaire   +3 more sources

Editorial: Standards in personalized phage therapy: from phage collection to phage production [PDF]

Saija Kiljunen, Grégory Resch
openalex   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Synthetic cells for phage therapy: a perspective. [PDF]

Front Cell Infect Microbiol
Kulkarni V, Laohakunakorn N, Liyanagedera SBW.   +2 more
europepmc   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source