Results 191 to 200 of about 116,117 (334)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Phage Therapy at the Crossroads Between Clinical Promise and Regulatory Challenge. [PDF]

Pharmaceuticals (Basel)
Gallina A, Gallina M, Cona A, Vitulo P, Mularoni A, Provenzani A.   +5 more
europepmc   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Phage therapy in revision arthroplasty: State of the art and application protocols. [PDF]

Arthroplasty
Wolfgart JM, Schenker H, Gatz M, Migliorini F, Eschweiler J, Langwald S, Horz HP, Eisert A, Schwanz T, Hofmann UK.   +9 more
europepmc   +1 more source

The potential use of phage therapy in the treatment of exacerbated chronic suppurative otitis media

Kriukov Ai, А. В. Гуров, E G Lapenko   +2 more
openalex   +2 more sources

Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages [PDF]

, 2016
Agata Anna Cisek, Iwona Dąbrowska, Karolina P. Gregorczyk-Zboroch, Zbigniew Wyżewski   +3 more
openalex   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

mGem: Immune recognition and clearance of bacteriophages-implications for phage therapy. [PDF]

mBio
Le HT, Ahlenstiel G, Venturini C, Read SA.   +3 more
europepmc   +1 more source

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Phages and quorum sensing: findings to consider in phage therapy. [PDF]

Eur J Clin Microbiol Infect Dis
Fernández-Garcia L, Blasco L, Bleriot I, Arman L, Ibarguren-Quiles C, Barrio-Pujante A, de Aledo MG, García-Contreras R, Cantón R, Wood TK, Tomas M.   +10 more
europepmc   +1 more source