Results 291 to 300 of about 4,525,509 (335)

Optimizing phage therapy for carbapenem-resistant <i>Enterobacter cloacae</i> bacteremia: insights into dose and timing. [PDF]

Antimicrob Agents Chemother
Fu S-Y, Chen X-Z, Yi P-C, Gao J, Wang W-X, Gu S-L, Gao J-H, Liu D-X, Xu H-F, Zeng Y, Hu C-M, Zheng Q, Chen W.   +12 more
europepmc   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, Volume 44, Issue 5, Page 715-756, September/October 2025.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Phage therapy: A novel approach against multidrug-resistant pathogens. [PDF]

3 Biotech
Kapoor A, Mudaliar SB, Bhat VG, Chakraborty I, Prasad ASB, Mazumder N.   +5 more
europepmc   +1 more source

Annexin A1‐Targeted d‐Peptide‐Monomethyl Auristatin E Conjugate Enhanced Antitumor Effect of Monomethyl Auristatin E for Chemotherapy of Prostate Cancer

The Prostate, Volume 85, Issue 13, Page 1208-1221, September 15, 2025.
ABSTRACT Background N‐terminus 15 amino acid (MC16) of Annexin A1 (ANXA1) is an effective therapeutic target for tumors and tumor vasculature as it specifically localizes to the cell surface of tumor cells and tumor vascular endothelial cells. We identified the d‐type peptide (hpnevrs, dhp7) by mirror‐image phage display targeting l‐type MC16 and ...
Kai Ozaki, Tohru Yoneyama, Yuka Kubota, Mihoko Sutoh Yoneyama, Motohiro Nonaka, Tomonori Suzuki, Ryuma Tanaka, Chikara Ohyama, Shingo Hatakeyama   +8 more
wiley   +1 more source

Pharmacodynamic Evaluation of Phage Therapy in Ameliorating ETEC-Induced Diarrhea in Mice Models. [PDF]

Microorganisms
Xiong Y, Xia L, Zhang Y, Zhao G, Zhang S, Ma J, Cheng Y, Wang H, Sun J, Yan Y, Wang Z.   +10 more
europepmc   +1 more source

Modulating Antimicrobial Activity and Structure of the Peptide Esc(1‐21) via Site‐Specific Isopeptide Bond Formation

Journal of Peptide Science, Volume 31, Issue 9, September 2025.
The introduction of an isopeptide bond at the lysine residues in the backbone of Esc(1‐21) led to the generation of five analogs. Among these, Esc(1‐21)ε20 showed the most promising features, having antimicrobial activity comparable with those of the parent peptide, a lower cytotoxicity, and a higher stability to proteolytic degradation.
Bruno Casciaro, Daniel Ben Hur, Daniela Roversi, Carlo Vetrano, Edo Kiper, Giacomo Cappella, Federico Carneri, Eeva Tortellini, Lorenzo Stella, Neta Regev‐Rudzki, Yechiel Shai, Maria Luisa Mangoni   +11 more
wiley   +1 more source

Challenges and opportunities of phage therapy for <i>Klebsiella pneumoniae</i> infections. [PDF]

Appl Environ Microbiol
Kou X, Yang X, Zheng R.
europepmc   +1 more source

Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Nanoparticles are transforming animal care by enhancing nutrition, drug delivery and disease prevention. This study highlights their role in improving nutrient absorption in livestock, facilitating targeted drug delivery and boosting vaccine efficacy. Additionally, nanoparticles effectively reduce harmful mycotoxins in animal feeds, promoting overall ...
Mohsen Kazemi
wiley   +1 more source

Real-time monitoring by interferometric light microscopy of phage suspensions for personalised phage therapy. [PDF]

Sci Rep
Lapras B, Merienne C, Eynaud E, Usseglio L, Marchand C, Médina M, Kolenda C, Briot T, Laurent F, Pirot F, PHAGEinLYON.   +10 more
europepmc   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, Volume 12, Issue 29, August 7, 2025.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source