Results 231 to 240 of about 41,388 (353)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Emergence of transmissible <i>mcr-9.1</i> plasmids in clinical <i>Cronobacter sakazakii</i>: CRISPR typing unravels phage-driven evolution and high-risk lineage. [PDF]

Appl Environ Microbiol
Zeng H, Zou H, Huang X, Liang B, Liu S, Zhao W, Xu M, Chen M.   +7 more
europepmc   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Can we escape from top-priority ESKAPE pathogens? [PDF]

Emerg Microbes Infect
Zeng L, Feng Y, Wang M.
europepmc   +1 more source

The biological base of Salmonella phage typing

, 2001
Wolfgang Rabsch, Horst Schmieger
openalex   +2 more sources

A Review of Phage Therapy for Aquaculture Applications: Efficacy, Health Ramifications and Research Challenges

Fish and Fisheries, EarlyView.
Bacteriophage therapy is characterised by numerous advantages, facilitating its diverse aquaculture application and efficacy as an antibiotic alternative mitigating the spread of antimicrobial‐resistant pathogens. Contributing to the modern reappraisal of the aquaculture application of bacteriophage therapy, challenges impeding its widespread ...
Louise James, Tamsyn M. Uren Webster, Gethin Thomas, Mathias Middelboe, Sofia Consuegra   +4 more
wiley   +1 more source

Improved detection of Listeria monocytogenes outbreaks using whole genome sequencing, Gipuzkoa, Northern Spain, 2010 to 2022. [PDF]

BMC Microbiol
Vallejo P, Moura A, López-Olaizola M, Leclercq A, Vicente D, Lecuit M, Marimón JM.   +6 more
europepmc   +1 more source

Importance of case age in the purported association between phylogenetics and hemolytic uremic syndrome in Escherichia coli O157:H7 infections [PDF]

, 2018
Besser, T.E., Mayer, J., Oltean, H.N., Phipps, A.I., Rabinowitz, P., Shringi, S., Tarr, G.A.M., Tarr, P.I., Wakefield, J.   +8 more
core   +1 more source

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage. [PDF]

J Infect Dis
Felton EA, Jobson ME, Torres NJ, Washburn RM, Virgillio AM, Alvior J, Cella E, Lima A, Becker D, Silbert S, Azarian T, Kim K, Shaw LN.   +12 more
europepmc   +1 more source