Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang +10 more
wiley +1 more source
Beyond antibiotics: Harnessing phage depolymerases to control multidrug-resistant Klebsiella pneumoniae. [PDF]
Dias Silva EE +10 more
europepmc +1 more source
Cost of parasite exposure depends on host ontogeny 寄生接觸的代價依賴於宿主發育階段
The cost of parasite exposure varies across host developmental stages, demonstrating that ontogeny influences the expression of non‐consumptive effects (NCEs). Mite exposure resulted in consumptive effects in fly eggs and NCEs in early‐stage pupae; mite longevity was comparable when provisioned with pupae or water but increased when provisioned with ...
Lisa R. MacLeod +2 more
wiley +1 more source
Efficacy of precisely tailored phage cocktails targeting carbapenem-resistant Acinetobacter baumannii reveals evolutionary trade-offs: a proof-of-concept study. [PDF]
Liu Z +14 more
europepmc +1 more source
Phage typing in straphylodermia.
G, BRUNDIN, G, LAURELL
openaire +1 more source
Importance of case age in the purported association between phylogenetics and hemolytic uremic syndrome in Escherichia coli O157:H7 infections [PDF]
Besser, T.E. +8 more
core +1 more source
Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
Prevalence and genomic insights into type III-A CRISPR-Cas system acquisition in global <i>Staphylococcus argenteus</i> strains. [PDF]
Chen X +7 more
europepmc +1 more source

