Results 31 to 40 of about 700 (134)

Healthy human gut phageome [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Humans need a stable, balanced gut microbiome (GM) to be healthy. The GM is influenced by bacteriophages that infect bacterial hosts. In this work, bacteriophages associated with the GM of healthy individuals were analyzed, and a healthy gut phageome (HGP) was discovered.
Manrique, Pilar, Bolduc, Benjamin, Walk, Seth T., van der Oost, John, de Vos, Willem M., Young, Mark J.   +5 more
openaire   +4 more sources

Primate phageomes are structured by superhost phylogeny and environment [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Mammals harbor diverse communities of gut microbes. The assembly and evolution of the bacterial components of these communities are influenced by host evolutionary histories and social behavior. Little is known about the ecological and evolutionary origins of the phages infecting these bacteria.
Jan F. Gogarten, Malte Rühlemann, Elizabeth Archie, Jenny Tung, Chantal Akoua-Koffi, Corinna Bang, Tobias Deschner, Jean-Jacques Muyembe-Tamfun, Martha M. Robbins, Grit Schubert, Martin Surbeck, Roman M. Wittig, Klaus Zuberbühler, John F. Baines, Andre Franke, Fabian H. Leendertz, Sébastien Calvignac-Spencer   +16 more
openaire   +4 more sources

Factors Affecting Variation of the Human Gut Phageome

Annual Review of Microbiology, 2023
The gut microbiome is a dense and metabolically active consortium of microorganisms and viruses located in the lower gastrointestinal tract of the human body. Bacteria and their viruses (phages) are the most abundant members of the gut microbiome. Investigating their biology and the interplay between the two is important if we are to understand their ...
Ciara A, Tobin, Colin, Hill, Andrey N, Shkoporov   +2 more
openaire   +2 more sources

The phageome in normal and inflamed human skin

Science Advances, 2022
Dysbiosis of skin microbiota drives the progression of atopic dermatitis (AD). The contribution of bacteriophages to bacterial community compositions in normal and inflamed skin is unknown. Using shotgun metagenomics from skin swabs of healthy individuals and patients with AD, we found 13,586 potential viral contiguous DNA sequences, which could be ...
Wielscher, M., Pfisterer, K., Samardzic, D., Balsini, P., Bangert, C., Jäger, K., Buchberger, M., Selitsch, B., Pjevac, P., Willinger, B., Weninger, W.   +10 more
openaire   +2 more sources

Phageome Analysis of Bifidobacteria-Rich Samples

, 2021
Bifidobacteria are important early colonizers of the human intestinal tract. The relative abundance of bifidobacterial species may be modulated, in part, by bacteriophage activity. Metagenomic studies of these populations is a crucial step in understanding this important interaction.
McDonnell, Brian, Casey, Eoghan, Milani, Christian, Lugli, Gabriele Andrea, Viappiani, Alice, Mahony, Jennifer, Ventura, Marco, van Sinderen, Douwe   +7 more
openaire   +3 more sources

Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus

mBio, 2022
Mosquitoes are important vectors for many arboviruses. It is becoming increasingly clear that various symbiotic microorganisms (including bacteria and insect-specific viruses; ISVs) in mosquitoes have the potential to modulate the ability of mosquitoes ...
Chenyan Shi, Leen Beller, Lanjiao Wang, Ana Rosales Rosas, Lander De Coninck, Lyza Héry, Laurence Mousson, Nonito Pagès, Jeroen Raes, Leen Delang, Anubis Vega-Rúa, Anna-bella Failloux, Jelle Matthijnssens   +12 more
doaj   +1 more source

Phage Diversity in the Human Gut Microbiome: a Taxonomist’s Perspective

mSystems, 2021
Bacteriophages (phages) have been known for over a century, but only in the last 2 decades have we really come to appreciate how abundant and diverse they are.
Evelien M. Adriaenssens
doaj   +1 more source

Long‐Read Sequencing Reveals Extensive DNA Methylations in Human Gut Phagenome Contributed by Prevalently Phage‐Encoded Methyltransferases

Advanced Science, Volume 10, Issue 25, September 5, 2023., 2023
A comprehensive survey using long‐read sequencing in 8848 gut phages across 104 fecal samples uncovers widespread DNA methylation (≈98%) and its potential benefits for phage viability. Intriguingly, over one‐third of the phages encode their own DNA methyltransferases, contributing to enhanced genome methylation.
Chuqing Sun, Jingchao Chen, Menglu Jin, Xueyang Zhao, Yun Li, Yanqi Dong, Na Gao, Zhi Liu, Peer Bork, Xing‐Ming Zhao, Wei‐Hua Chen   +10 more
wiley   +1 more source

Mammal mitogenomics from invertebrate‐derived DNA

Environmental DNA, Volume 5, Issue 5, Page 1004-1015, September 2023., 2023
The metabarcoding of vertebrate DNA found in invertebrates (iDNA) has proven a powerful tool for monitoring biodiversity. To date, iDNA has primarily been used to detect the presence/absence of particular taxa using metabarcoding. Here, we show that iDNA extracts often allow for the recovery of complete mammalian mitochondrial genomes, which paves the ...
Renita Danabalan, Kevin Merkel, Ida Bærholm Schnell, Mimi Arandjelovic, Christophe Boesch, Gregory Brazzola, Paula Dieguez, Jef Dupain, Magloire Kambale‐Vyalengerera, Hjalmar S. Kühl, Constanze Hoffmann, Juan Lapuente, Van Ngoc Thinh, Fee Zimmermann, Fabian H. Leendertz, M. Thomas P. Gilbert, Christian Roos, Camila Mazzoni, Jan F. Gogarten, Sébastien Calvignac‐Spencer   +19 more
wiley   +1 more source

Multiomic spatial analysis reveals a distinct mucosa-associated virome

Gut Microbes, 2023
The human gut virome has been increasingly explored in recent years. However, nearly all virome-sequencing efforts rely solely on fecal samples and few studies leverage multiomic approaches to investigate phage–host relationships.
Austin Yan, James Butcher, Laetitia Schramm, David R. Mack, Alain Stintzi   +4 more
doaj   +1 more source