Results 41 to 50 of about 700 (134)

Limitations of using 16S rRNA microbiome sequencing to predict oral squamous cell carcinoma

APMIS, Volume 131, Issue 6, Page 262-276, June 2023., 2023
A new era of next‐generation sequencing has changed our perception of the oral microbiome in health and disease, and with this there is a growing understanding that the oral microbiome is a contributing factor to oral squamous cell carcinoma (OSCC), a malignancy of the oral cavity. This study aimed to analyse the trends and relevant literature based on
Christopher Delaney, Chandra Lekha Ramalingam Veena, Mark C. Butcher, William McLean, Suror Mohamad Ahmad Shaban, Christopher J. Nile, Gordon Ramage   +6 more
wiley   +1 more source

Microbiota‐related metabolites fueling the understanding of ischemic heart disease

iMeta, Volume 2, Issue 2, May 2023., 2023
Up‐to‐date knowledge of gut microbial taxa associated with ischemic heart disease (IHD). Microbial metabolites for mechanistic dissection of IHD pathology. Microbiome‐based therapies in IHD prevention and treatment.
Yong Fan, Jiajun Ying, Hongchuang Ma, Hanbin Cui   +3 more
wiley   +1 more source

Expanding the Colorectal Cancer Biomarkers Based on the Human Gut Phageome

Microbiology Spectrum, 2021
Worldwide, by 2020, colorectal cancer has become the third most common cancer after lung and breast cancer. Phages are strictly host-specific, and this specificity makes them more accurate as biomarkers, but phage biomarkers for colorectal cancer have not been thoroughly explored.
Siyuan Shen, Dongxue Huo, Chenchen Ma, Shuaiming Jiang, Jiachao Zhang   +4 more
openaire   +3 more sources

Needle in a Whey-Stack: PhRACS as a Discovery Tool for Unknown Phage-Host Combinations

mBio, 2022
The field of metagenomics has rapidly expanded to become the go-to method for complex microbial community analyses. However, there is currently no straightforward route from metagenomics to traditional culture-based methods of strain isolation ...
Eoghan Casey, Brian McDonnell, Kelsey White, Panagiota Stamou, Tadhg Crowley, Ian O’Neill, Katherine Lavelle, Stephen Hayes, Gabriele A. Lugli, Silvia Arboleya, Kieran James, Marco Ventura, Ines Martinez, Miguel Gueimonde, Fabio dal Bello, Ken Nally, Jennifer Mahony, Douwe van Sinderen   +17 more
doaj   +1 more source

Gut microbiome and neurosurgery: Implications for treatment

Clinical and Translational Discovery, Volume 2, Issue 4, December 2022., 2022
There is a strong bidirectional link between gut microbiome dysbiosis and worsening secondary injury post‐stroke, SCI, and TBI.These deficits may be rescued by timely rejuvenation of the gut microbiome. The maintenance of a healthy microbiome plays a protective role in the setting of tumor chemotherapy and immunotherapy.
Jonathan Willman, Matthew Willman, Ramya Reddy, Anna Fusco, Sai Sriram, Yusuf Mehkri, Jude Charles, Joel Goeckeritz, Brandon Lucke‐Wold   +8 more
wiley   +1 more source

Dynamics of nasopharyngeal tract phageome and association with disease severity and age of patients during three waves of COVID‐19

Journal of Medical Virology, Volume 94, Issue 11, Page 5567-5573, November 2022., 2022
Abstract In December 2019, several patients were hospitalized and diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, which subsequently led to a global pandemic. To date, there are no studies evaluating the relationship between the respiratory phageome and the SARS‐CoV‐2 infection.
Carlo Ferravante, Berin S. Arslan‐Gatz, Federica Dell'Annunziata, Domenico Palumbo, Jessica Lamberti, Elena Alexandrova, Domenico Di Rosa, Oriana Strianese, Alessandro Giordano, Luigi Palo, Giorgio Giurato, Francesco A. Salzano, Massimiliano Galdiero, Alessandro Weisz, Gianluigi Franci, Francesca Rizzo, Veronica Folliero   +16 more
wiley   +1 more source

Signals triggering prophage induction in the gut microbiota

Molecular Microbiology, Volume 118, Issue 5, Page 494-502, November 2022., 2022
Gut signals inducing prophages. Abstract Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying prophages.
Caroline Henrot, Marie‐Agnès Petit
wiley   +1 more source

Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application

Viruses, 2022
The human microbiome and its importance in health and disease have been the subject of numerous research articles. Most microbes reside in the digestive tract, with up to 1012 cells per gram of faecal material found in the colon. In terms of gene number,
Norbert Ács, Ross Holohan, Laura J. Dunne, Adrian R. Fernandes, Adam G. Clooney, Lorraine A. Draper, R. Paul Ross, Colin Hill   +7 more
doaj   +1 more source

Bacteriophage-mediated manipulations of microbiota in gastrointestinal diseases

Frontiers in Microbiology, 2022
Although some gastrointestinal diseases could be managed using various antibiotics regimen, this therapeutic approach lacks precision and damages the microbiota. Emerging literature suggests that phages may play a key role in restoring the gut microbiome
Lynn El Haddad, Lynn El Haddad, Jesus F. Mendoza, Christian Jobin, Christian Jobin, Christian Jobin   +5 more
doaj   +1 more source

Probing the “Dark Matter” of the Human Gut Phageome: Culture Assisted Metagenomics Enables Rapid Discovery and Host-Linking for Novel Bacteriophages

Frontiers in Cellular and Infection Microbiology, 2021
Recent years have been marked by the growing interest towards virulent and temperate bacteriophage populations inhabiting the human lower gastrointestinal tract – the gut phageome.
C. Brian Fitzgerald, Andrey N. Shkoporov, Aditya Upadrasta, Ekaterina V. Khokhlova, R. Paul Ross, Colin Hill   +5 more
doaj   +1 more source