Results 61 to 70 of about 700 (134)

Gut dsDNA virome shows diversity and richness alterations associated with childhood obesity and metabolic syndrome

iScience, 2021
Summary: Changes in the human gut microbiome are associated with obesity and metabolic syndrome, but the role of the gut virome in both diseases remains largely unknown. We characterized the gut dsDNA virome of 28 school-aged children with healthy normal-
Shirley Bikel, Gamaliel López-Leal, Fernanda Cornejo-Granados, Luigui Gallardo-Becerra, Rodrigo García-López, Filiberto Sánchez, Edgar Equihua-Medina, Juan Pablo Ochoa-Romo, Blanca Estela López-Contreras, Samuel Canizales-Quinteros, Abigail Hernández-Reyna, Alfredo Mendoza-Vargas, Adrian Ochoa-Leyva   +12 more
doaj   +1 more source

Gut Phageome Analysis Reveals Disease-Specific Hallmarks in Childhood Obesity [PDF]

, 2020
AbstractChanges in the composition of the human gut microbiome are recognized to have a significant association with obesity and metabolic syndrome. Mexico leads worldwide childhood-obesity rankings representing an epidemic problem for public health.
Shirley Bikel, Gamaliel López-Leal, Fernanda Cornejo-Granados, Luigui Gallardo-Becerra, Filiberto Sánchez, Edgar Equihua-Medina, Juan Pablo Ochoa-Romo, Blanca Estela López-Contreras, Samuel Canizales-Quinteros, Adrian Ochoa Leyva   +9 more
openaire   +1 more source

Long-read metagenomics using PromethION uncovers oral bacteriophages and their interaction with host bacteria

Nature Communications, 2021
Here, the authors profile the oral phageome of 4 healthy individuals via longread shotgun metagenomics using PromethION, a recently developed highthroughput nanopore sequencer, and uncover potential new candidate phages with enhanced scaffolding and ...
Koji Yahara, Masato Suzuki, Aki Hirabayashi, Wataru Suda, Masahira Hattori, Yutaka Suzuki, Yusuke Okazaki   +6 more
doaj   +1 more source

Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission. [PDF]

J Clin Biochem Nutr
This study aimed to analyze the gut phageome in Japanese patients with ulcerative colitis (UC) in endoscopic remission. Fecal samples were collected from 35 UC patients and 22 healthy controls. The gut microbiome was analyzed using 16S rRNA amplicon sequencing, and the phageome was profiled through shotgun metagenomic sequencing.
Otsuki A, Inoue R, Imai T, Miura H, Nishida A, Inatomi O, Andoh A.   +6 more
europepmc   +3 more sources

Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease

Cells, 2020
Inflammatory bowel diseases (IBDs) are a group of chronic autoinflammatory diseases including Crohn’s disease and ulcerative colitis. Although the molecular mechanisms governing the pathogenesis of gastrointestinal inflammation are not completely clear ...
Martin Maronek, Rene Link, Lubos Ambro, Roman Gardlik   +3 more
doaj   +1 more source

The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges

Advanced Genetics, Volume 6, Issue 4, December 2025.
This article examines how the respiratory virome contributes to health and disease, highlighting its interactions with the host and bacteriome. Key disease associations and present knowledge gaps are outlined. The review discusses challenges in sample collection and preprocessing, and presents future research directions for understanding virome ...
Xiaoxuan Yao, Xiaohui Zou, Bin Cao
wiley   +1 more source

An Exploration of DNA Extraction Methods of Fly iDNA for Scalable Biodiversity Monitoring

Environmental DNA, Volume 7, Issue 6, November–December 2025.
Metabarcoding of invertebrate‐derived DNA (iDNA) is an excellent tool for assessing terrestrial mammal diversity, but the time and costs associated with sample processing constrain its wider adoption. Our study indicates that the non‐destructive extraction of large pools of entire fly bodies has the potential to streamline and reduce the costs of fly ...
Mueena Jahan, Christina Lynggaard, Anthony Agbor, Samuel Angedakin, Alix Armero, Katherine Corogenes, Paula Dieguez, Sorrel Jones, Simon Krückemeier, Kevin E. Langergraber, Kevin C. Lee, Mizuki Murai, Emmanuelle Normand, Joost van Schijndel, Volker Sommer, Erin G. Wessling, Fabian H. Leendertz, Christophe Boesch, Hjalmar S. Kühl, Mimi Arandjelovic, Jan F. Gogarten, Sébastien Calvignac‐Spencer   +21 more
wiley   +1 more source

Gut Virome: What's the Role in Irritable Bowel Syndrome?

Reviews in Medical Virology, Volume 35, Issue 6, November 2025.
ABSTRACT The gut virome, an integral but still poorly understood component of the gut microbiota, is emerging as an important player in the pathophysiology of irritable bowel syndrome (IBS). Recent evidence suggests that alterations in virome diversity and phage–bacteria interactions contribute to gut dysbiosis, immune modulation and gut barrier ...
Francesco Rettura, Christian Lambiase, Andrea Bottari, Fabio Filippini, Luca Giacomelli, Mauro Pistello, Massimo Bellini   +6 more
wiley   +1 more source

Sequencing Approach Enables More In-depth Phageome Investigation

, 2023
Sequencing technologies, genomics, and bioinformatics are rapid and effective tools to study phage genomics. In addition, further analysis, including transcription, translation, regulation, and modification, are also emerging techniques that are extremely helpful in exploring the life cycle, specificity, lytic ability, and lysogenicity of phages. Today,
openaire   +1 more source

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source