Results 161 to 170 of about 99,433 (208)
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Phage-Phage, Phage-Bacteria, and Phage-Environment Communication
2020Besides obtaining and utilizing resources, organisms have three basic ecological tasks: to survive, to reproduce, and to move. Survival is necessary for reproduction, reproduction increases numbers, and movement at a minimum assures that all of an organism’s ‘eggs’ are not found in the same spatial ‘basket’.
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2007
The vast majority of novel DNA sequences deposited in the databases now comes from environmental phage DNA sequences. Methods are presented for the cloning and sequencing of phage DNA that might otherwise be lethal to bacterial host vectors or contain modified DNA bases that prevent standard cloning of such sequences. In addition, methods are presented
Veronica, Casas, Forest, Rohwer
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The vast majority of novel DNA sequences deposited in the databases now comes from environmental phage DNA sequences. Methods are presented for the cloning and sequencing of phage DNA that might otherwise be lethal to bacterial host vectors or contain modified DNA bases that prevent standard cloning of such sequences. In addition, methods are presented
Veronica, Casas, Forest, Rohwer
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Current Biology, 2023
In this Quick guide, Harding et al. introduce jumbo phages - the overlooked giants of the phage universe.
Kate R, Harding +2 more
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In this Quick guide, Harding et al. introduce jumbo phages - the overlooked giants of the phage universe.
Kate R, Harding +2 more
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Intra-phage immunity: Set a (pro)phage to catch a phage
Cell Host & MicrobeIn this issue, Brenes and Laub screen temperate phages for defenses against other temperate phages. This uncovers an array of prophage-encoded immune systems in E. coli. The work expands the concept of phage-phage conflict, reveals context dependency of defense, and highlights temperate phages as both targets and carriers of anti-phage immunity.
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Vibrio Phages and Phage-Typing
1992The first vibrio phages were identified by d’Herelle in 1926, and by the 1950s several distinct types of bacteriophage acting on V. cholerae had been described. These studies of cholera bacteriophages have been reviewed by Pollitzer.1 Most early studies were directed towards the use of cholera phages for treatment or prophylaxis rather than strain ...
B. Rowe, J. A. Frost
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Drug Discovery Today, 2009
There is a renaissance of interest in the antimicrobial potential of phages as more pathogens become multiply antibiotic resistant. Phage therapy is not a new concept, and it is important to ask why it is not part of the current repertoire of western medicine despite the fact that it has been continuously and extensively used in Eastern Europe for ...
John N, Housby, Nicholas H, Mann
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There is a renaissance of interest in the antimicrobial potential of phages as more pathogens become multiply antibiotic resistant. Phage therapy is not a new concept, and it is important to ask why it is not part of the current repertoire of western medicine despite the fact that it has been continuously and extensively used in Eastern Europe for ...
John N, Housby, Nicholas H, Mann
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Molecular Microbiology, 1996
SummaryThere has recently been great interest in the use of the filamentous bacteriophage fd as a vehicle for the display of peptides and proteins. Phage libraries displaying random peptides up to 38 amino acids in length can be used (i) to select for ligands able to bind specific target molecules; (ii) to mimic non‐proteinaceous ligands; and (iii) as ...
H R, Hill, P G, Stockley
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SummaryThere has recently been great interest in the use of the filamentous bacteriophage fd as a vehicle for the display of peptides and proteins. Phage libraries displaying random peptides up to 38 amino acids in length can be used (i) to select for ligands able to bind specific target molecules; (ii) to mimic non‐proteinaceous ligands; and (iii) as ...
H R, Hill, P G, Stockley
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Immunotechnology, 1995
Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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1996
Bacteriophage genomes encode lysozymes whose role is to favour the release of virions by lysis of the host cells or to facilitate infection. In this review, the evolutionary relationships between the phage lysozymes are described. They are grouped into several classes: the V-, the G-, the lambda- and the CH-type lysozymes.
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Bacteriophage genomes encode lysozymes whose role is to favour the release of virions by lysis of the host cells or to facilitate infection. In this review, the evolutionary relationships between the phage lysozymes are described. They are grouped into several classes: the V-, the G-, the lambda- and the CH-type lysozymes.
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Phage Vaccines and Phage Therapy
2011The application of combinatorial approaches in conjunction with phage display techniques might be critical for development of vaccines against various infective and cancer diseases. Phage technique allows the generation of novel immunogens representing structural/molecular mimics of pathogen-derived immunodominant epitopes, or protein domains displayed
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