Results 171 to 180 of about 221,253 (266)

Red Blood Cell Glycation Triggers In Vivo Cerebral Erythrophagocytosis in Adult Zebrafish in a Model Mimicking Hemorrhagic Stroke. [PDF]

Compr Physiol
Morello E, Rondeau P, Canonne-Hergaux F, Bourdon E, Bringart M, Meilhac O, Couret D, Diotel N.   +7 more
europepmc   +1 more source

The Conserved ESCRT-III Machinery Participates in the Phagocytosis of Entamoeba histolytica

, 2018
Yunuen Avalos‐Padilla, Roland L. Knorr, Rosario Javier‐Reyna, Guillermina Garcı́a-Rivera, Reinhard Lipowsky, Rumiana Dimova, Esther Orozco   +6 more
openalex   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis. [PDF]

J Neuroinflammation
Ji Q, Zhang Y, Zhang Z, Cui K, Zhao L, Sun X, Qu H, Song J, Xiao J, Zhang X, Lu Y, Xu J, Li D.   +12 more
europepmc   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

Advanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi, Renliang Zhao, Jia Wang, Zhenchen Xiong, Xiangtian Deng, Cheng Zheng, Wenzhi Zhang   +6 more
wiley   +1 more source

If Plan A Does Not Work: The CD47 Ectodomain as a Target for Immune Tolerance. [PDF]

Cells
Montero E, Isenberg JS.
europepmc   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

<i>Ganoderma microsporum</i> Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib. [PDF]

J Cancer
Hsieh YC, Hsin IL, Chiu LY, Hung YC, Kang YT, Chang HY, Lin CH, Ko JL, Liu YF.   +8 more
europepmc   +1 more source

Techniques to study phagocytosis and uptake of Leishmania tarentolae by J774 macrophages

, 2019
Gerald Geroldinger, Marlene Rezk, Rugaia Idris, Victoria‐Elisabeth Gruber, Matthias Tonner, Rudolf Moldzio, Katrin Staniek, Lianet Monzote, Lars Gille   +8 more
openalex   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source