Results 231 to 240 of about 221,253 (266)

Role of Macrophage Phagocytosis as Predictive Marker of the Prevalence of Coronary Heart Disease and Acute Coronary Syndromes. [PDF]

Cardiovasc Ther
Wang Y, Zhou W, Zhou Q, Du C, Tang Y, Zhu K.   +5 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications for the development of therapeutic or early detection strategies. [PDF]

Front Aging Neurosci
Zhang M, Hou H, Li H, Bai X, Song H, Wang L, Jiang LH.   +6 more
europepmc   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells. [PDF]

Front Immunol
Umar S, Chang HT, Maienschein-Cline M, Ravindran S.   +3 more
europepmc   +1 more source

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies. [PDF]

J Hematol Oncol
Chong SJF, Valentin R, Wang J, Zhu F, Gokhale PC, Eschle BK, Garbicz F, Iskandar K, Sewastianik T, Toh BCY, Penailillo J, Peluso MO, Zhang J, Hackett L, Collins MC, Lehmberg TZ, Adam A, Zhang L, Armet CM, Rausch M, Lee BH, Holland PM, Palombella VJ, Paterson AM, Kong LR, Ten Hacken E, Guerriero JL, Herbaux C, Wu CJ, Chng WJ, Pervaiz S, Niemann CU, Carrasco RD, Davids MS.   +33 more
europepmc   +1 more source

Key features of the innate immune response is mediated by the immunoproteasome in microglia. [PDF]

Sci Rep
Izadjoo S, Moritz KE, Khayrullina G, Bergman EM, Melvin BM, Stinson MW, Paulson SG, McCormack NM, Anderson KN, Lewis LA, Rotty JD, Burnett BG.   +11 more
europepmc   +1 more source

A CD47 antibody with minimized erythrocyte and thrombocyte toxicities. [PDF]

Front Oncol
Pei M, Dai XD, Jiang XF, Yuan CY, Tan J, He KF, Liu GJ, Zhu JD, Li HH, Pan AL, Wang YR, Chen YL, Chen XJ, Wang C.   +13 more
europepmc   +1 more source