Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19 [PDF]
Cells 2020, 9(6), 1461, 2020 There is no vaccine or specific antiviral treatment for COVID-19. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown. It is therefore challenging to discover a successful treatment to be approved for clinical use.
arxiv +1 more source
The effects of honey compared with sucrose and a sugar-free diet on neutrophil phagocytosis and lymphocyte numbers after long-term feeding in rats [PDF]
, 2007 To determine whether honey and sucrose would have differential effects on levels of neutrophil phagocytosis after long-term feeding 36 2-month old Sprague Dawley rats were fed a powdered diet that was either sugar-free or contained 7.9% sucrose or 10 ...
Chepulis, Lynne Merran
core +2 more sources
Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface [PDF]
Int Immunopharmacol International Immunopharmacology. 2021 Mar
20;94:107457, 2021 The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a central role in host defense and are responsible for in vivo nanoparticle trafficking.
arxiv +1 more source
Studying Membrane Biogenesis with a Luciferase-Based Reporter Gene Assay [PDF]
, 2008 To study the coordination of different lipid synthesis pathways during membrane biogenesis it is useful to work with an experimental system where membrane biogenesis occurs rapidly and in an inducible manner.
Nohturfft, A, Zhang, S
core +2 more sources
Nanoelectrodes for intracellular measurements of reactive oxygen and nitrogen species in single living cells [PDF]
Current Opinion in Electrochemistry, Elsevier, 2020, 22, pp.44-50, 2020 Reactive oxygen and nitrogen species (ROS and RNS) play important roles in various physiological processes (e.g., phagocytosis) and pathological conditions (e.g., cancer). The primary ROS/RNS, viz., hydrogen peroxide, peroxynitrite ion, nitric oxide, and nitrite ion, can be oxidized at different electrode potentials and therefore detected and ...
arxiv +1 more source
Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
core +2 more sources
Cell Reports, 2021 Summary: Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by macrophages and is a promising avenue in anti-cancer therapy.
Zhenghai Tang +6 more
doaj
Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor [PDF]
, 2013 Phagocytosis of apoptotic cells (efferocytosis) induces macrophage differentiation towards a regulatory phenotype (IL-10high/IL-12p40low). CD36 is involved in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor ...
Ferracini, M. +3 more
core +2 more sources
CD22 blockade restores homeostatic microglial phagocytosis in aging brains
Nature, 2019 Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during ageing and neurodegenerative disease, concomitant with cognitive decline.
John V. Pluvinage +17 more
semanticscholar +1 more source
Identification of Drosophila gene products required for phagocytosis of Candida albicans.
PLoS Biology, 2006 Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster S2 cells as a model system to study the phagocytosis of Candida albicans, the major fungal pathogen of humans, by screening an RNAi library representing 7,216 ...
Shannon L Stroschein-Stevenson +3 more
doaj +2 more sources