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Phagocytosis of Microorganisms
For its survival, the host depends on an elaborate internal defense system to protect against persistent invasion by pathogenic microorganisms. This system is composed primarily of cellular and humoral components of the circulatory system and includes the "professional" phagocytes (polymorphonuclear leukocytes, monocytes, and tissue macrophages ...
openaire +5 more sources
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang+6 more
wiley +1 more source
We recently showed that both nontypeable Haemophilus influenzae (NTHi) and its surface plasminogen- (Plg-) binding proteins interact with lipoprotein(a) (Lp(a)) in a lysine-dependent manner.
Zhi Liu+6 more
doaj +1 more source
Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses.
Ming-Yue Wu, Jiahong Lu
semanticscholar +1 more source
Significance Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes, followed by neutrophil apoptosis and removal by macrophages. Neutrophils integrate cues from the
Meriem Sekheri+3 more
semanticscholar +1 more source
This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves+14 more
wiley +1 more source
PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway
Prostaglandin E2 (PGE2) is a potent lipid mediator of inflammation that modulates immune cell function by binding to unique G protein‐coupled receptors (EP receptors). PGE2 production increases during microbial infection and inflammation.
Zixuan Wang+5 more
doaj +1 more source
The origins of phagocytosis and eukaryogenesis [PDF]
Abstract Background Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found in diverse organisms and is often thought to be central to the very origin of the eukaryotic cell, in particular, for the acquisition of bacterial endosymbionts including the ancestor of the mitochondrion.
Maxim Y Wolf+3 more
openaire +4 more sources
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao+8 more
wiley +1 more source
Modulation (Inhibition and Augmentation) of Complement Receptor-3-Mediated Myelin Phagocytosis
The removal of damaged myelin is central to repair after injury to axons and in autoimmune demyelinating diseases. Complement receptor 3 (CR3/MAC-1) plays a major role in mediating the phagocytosis of damaged myelin by macrophages and microglia.
Fanny Reichert+3 more
doaj +1 more source