Results 51 to 60 of about 161,030 (250)

Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease

Alzheimer’s Research & Therapy, 2023
Background Hyperhomocysteinemia (HHcy) has been linked to development of Alzheimer’s disease (AD) neuropathologically characterized by the accumulation of amyloid β (Aβ).
Xianwei Wang, Lu Liu, Xiaohua Jiang, Jason Saredy, Hang Xi, Ramon Cueto, Danni Sigler, Mohsin Khan, Sheng Wu, Yong Ji, Nathaniel W. Snyder, Wenhui Hu, Xiaofeng Yang, Hong Wang   +13 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Phagocytic properties of lung alveolar wall cells [PDF]

, 1974
For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was
Tanaka, Akisuke
core   +1 more source

STUDIES ON PHAGOCYTOSIS. [PDF]

Journal of the American Medical Association, 1906
The studies of Leishman, of Wright and Douglas, of Neufeld and Rimpau, of McFarland and Engle, and of others, have opened up a new field of investigation for the elucidation of the problem of the mechanism of immunity. The experiments that have been reported thus far have dealt almost entirely with the opsonic powers of the blood serum against ...
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.

PLoS ONE, 2014
Phagocytosis, one of the most powerful immune responses, is a complicated process regulated by many factors. However the regulation of phagocytosis mediated by microRNAs has not been extensively investigated.
Cuilian Liu, Jiajia Wang, Xiaobo Zhang
doaj   +1 more source

The effect of phagocytosis of poly(L-lactic acid) fragments on cellular morphology and viability [PDF]

, 1993
The aim of this study was to investigate the effect of phagocytosed poly(L-lactic acid) particles on the morpholgy and viability of phagocytes, mainly macrophages. Therefore, predegraded poly(L-lactic acid) (P-PLLA) and nontreated PLLA (N-PLLA) particles,
Anderson, Bakker, Beller, Blaauw, Cotran, Hassan, Holmes, Hulsteart, Karnovsky, Kotani, Kotani, Lam, Marchant, Matlaga, McInnes, Most, Papadimitriou, Pizzoferrato, Rozema, Schakenraad, Schakenraad, Schindler, Schkenraad, Schnyder, Springer, van Wachem   +25 more
core   +3 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Neutrophilic Phagocytosis

Eurasian Journal of Medicine, 2019
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Ali Bayram, Özden Vural, Ebubekir Bakan
doaj  

Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation

Life Science Alliance
Upon Fc gamma R–mediated phagocytosis, Syk is palmitoylated by DHHC5 and desulfenylated on nearby Cys residues, and both modifications are important for Syk phosphorylation and phagocytosis.
Maxime Jansen, Jean-Marc Strub, Laurent Chaloin, Peter Coopman, Bruno Beaumelle   +4 more
doaj   +1 more source