Results 191 to 200 of about 13,993 (208)

Initiation, targeting and sculpting of the phagophore

The FASEB Journal, 2018
Autophagy is a conserved mechanism that is essential for cell survival in starvation and for cellular homeostasis. The autophagosome and the proteasome comprise the two main pathways for the degradation of proteins. Autophagy proceeds by the engulfment of bulk cytosol and organelles by a cup‐shaped double membrane sheet known as the phagophore, which ...
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Towards reconstitution of autophagy initiation and phagophore expansion

2022
Damit Zellen gesund und funktionsfähig bleiben, müssen schadhafte und überschüssige Bestandteile rasch und effizient beseitigt werden. Der dafür verantwortliche Prozess, der den Abbau und die Wiederverwertung von cytoplasmatischem Material wie defekten Organellen, gefährlichen Pathogenen oder aggregierten Proteinen (Cargo) ermöglicht, wird als ...
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Trans-Golgi protein p230/golgin-245 is involved in phagophore formation

Biochemical and Biophysical Research Communications, 2015
p230/golgin-245 is a trans-Golgi coiled-coil protein that is known to participate in regulatory transport from the trans-Golgi network (TGN) to the cell surface. We investigated the role of p230 and its interacting protein, microtubule actin crosslinking protein 1 (MACF1), in amino acid starvation-induced membrane transport.
Miwa, Sohda, Yoshio, Misumi, Shigenori, Ogata, Shotaro, Sakisaka, Shinichi, Hirose, Yukio, Ikehara, Kimimitsu, Oda   +6 more
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Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries

Nature Structural & Molecular Biology
Autophagy-related (Atg) proteins catalyze autophagosome formation at the phagophore assembly site (PAS). The assembly of Atg proteins at the PAS follows a semihierarchical order, in which Atg8 is thought to be quite downstream but still able to control the size of autophagosomes.
Jing-Zhen Song, Hui Li, Haiyan Yang, Rui Liu, Wenting Zhang, Tianlong He, Meng-Xi Xie, Chen Chen, Li Cui, Shian Wu, Yueguang Rong, Li-Feng Pan, Jing Zhu, Qingqiu Gong, Juan Wang, Zhao Qin, Zhiping Xie   +16 more
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Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore

Autophagy, 2021
Piotr Neumann, Roswitha Krick, Janina Metje-Sprink   +2 more
exaly  

­­Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy

Autophagy, 2023
Sabrina Vanesa Chumpen Ramirez, Rubén Gómez-Sánchez, Pauline Verlhac   +2 more
exaly  

Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy

Autophagy, 2021
Koji Yamano, Hidetaka Kosako, Kenichiro Imai   +2 more
exaly  

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

Cell, 2020
Patrick Giavalisco, Martin Graef
exaly  

ESCRT-mediated phagophore sealing during mitophagy

Autophagy, 2020
Hélène Spangenberg, Michael J Munson, Andreas Brech   +2 more
exaly  

ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

Molecular Cell, 2021
Thanh Ngoc Nguyen, Susanne Zellner, Louise Uoselis   +2 more
exaly