Results 181 to 190 of about 13,993 (208)
A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
Holzer E +5 more
europepmc +1 more source
VPS37A directs ESCRT recruitment for phagophore closure [PDF]
Journal of Cell Biology, 2019 The process of phagophore closure requires the endosomal sorting complex required for transport III (ESCRT-III) subunit CHMP2A and the AAA ATPase VPS4, but their regulatory mechanisms remain unknown. Here, we establish a FACS-based HaloTag-LC3 autophagosome completion assay to screen a genome-wide CRISPR library and identify the ESCRT-I subunit VPS37A ...
Yoshinori Takahashi +2 more
exaly +3 more sources
3D tomography reveals connections between the phagophore and endoplasmic reticulum [PDF]
Autophagy, 2009 Autophagosomes have been reported to form in the vicinity of the endoplasmic reticulum (ER). In many cases, the phagophore membrane is observed between two cisternae of rough ER, but it is not known whether these two membranes are directly connected.
Päivi Ylä-Anttila +1 more
exaly +3 more sources
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2021
Phagophore closure is a critical step during macroautophagy. However, the proteins and mechanisms to regulate this step have been elusive for a long time. In 2017, Rab5 was affirmed to play a role in phagophore closure in yeast. Furthermore, in mammalian cells, ESCRT III was reported to have roles in phagophore closure and mitophagosome closure in vivo
openaire +2 more sources
Phagophore closure is a critical step during macroautophagy. However, the proteins and mechanisms to regulate this step have been elusive for a long time. In 2017, Rab5 was affirmed to play a role in phagophore closure in yeast. Furthermore, in mammalian cells, ESCRT III was reported to have roles in phagophore closure and mitophagosome closure in vivo
openaire +2 more sources
A conserved ATG2‐GABARAP family interaction is critical for phagophore formation
EMBO Reports, 2020 The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain cellular homeostasis. An essential phase is the elongation and closure of the phagophore to seal and isolate unwanted cargo prior to lysosomal degradation.
Luuk van den Bekerom +2 more
exaly +4 more sources
ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes [PDF]
Autophagy, 2019 The mechanism by which ATG2 (ATG2A and ATG2B in mammals) regulates autophagosome biogenesis remains largely unknown. In our recent study, we showed that ATG2A translocates to the mitochondria-associated ER membranes (MAM) to promote phagophore growth during nutrient starvation. Mechanistically, the mitochondrial translocase TOMM40 binds to a C-terminal
Zhenyuan Tang +2 more
exaly +3 more sources
FREE1 regulates phagophore closure in plants
AutophagyAdenosine monophosphate-activated protein kinase (AMPK), the central energy sensor in more complex eukaryotes, can activate macroautophagy/autophagy upon cellular energy deficiency. However, the regulatory role of nutrient sensing in mediating phagophore closure to generate an autophagosome remains unknown.
Ying, Zhu, Yonglun, Zeng, Liwen, Jiang
openaire +2 more sources
Phagophore-lysosome/vacuole fusion in mutant yeast and mammalian cells
Autophagy, 2023Macroautophagy/autophagy is a process through which the phagophores engulf non-essential or damaged cellular materials, forming double-membrane autophagosomes (APs) and fusing with lysosomes/vacuoles, after which the materials are degraded for recycling purposes. Autophagy is associated with increased cell survival under different stress conditions. AP-
openaire +2 more sources
The role of FIP200 in Phagophore formation during Autophagy
The FASEB Journal, 2022The Moeller Molecular Modeling Team in conjunction with Dr. Jiajie Diao at the University of Cincinnati Medical College used 3D modeling and printing technology to study the vital role of the focal adhesion kinase family interacting protein of 200 kD (FIP200) in the autophagy process.
Daniel Shannon +6 more
openaire +1 more source
GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes
AutophagyAs the central hub of the secretory pathway, the Golgi apparatus plays a crucial role in maintaining cellular homeostasis in response to stresses. Recent studies have revealed the involvement of the Golgi tether, GORASP2, in facilitating autophagosome-lysosome fusion by connecting LC3-II and LAMP2 during nutrient starvation.
Xiaoyan Zhang
exaly +3 more sources