Results 91 to 100 of about 497 (134)
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Interaction of phallotoxins with actin
Advances in Enzyme Regulation, 1977Abstract Phalloidin (PHD) like its toxic relatives from the mushroom Amanita phalloides and like toxic derivatives obtained by chemical modifications combines with F-actin, thus stabilizing its polymer structure. Since there is no dissociation of F-actin to G-actin in presence of PHD F-actin filaments have been found in poisoned liver cells.
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Phallotoxins and Microfilaments
1976Phalloidin (Formula 1a) is one of the toxic components of the toadstool Amanita phalloides (Wieland, 1968); it is accompanied in the mushroom by several toxic relatives of which only phallacidin (Formula 1b) is shown in the general formula. Chemical manipulations can also lead to toxic derivatives or can annihilate the toxicity of the molecule.
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Is ligandin relevant for the uptake and storage of phallotoxins in liver cell?
Naunyn-Schmiedeberg's Archives of Pharmacology, 1981To exclude an involvement of ligandin in the uptake and storage of phalloidin in hepatocytes equilibrium-dialysis studies were made with phalloidin, cholic acid and bromosulfophthalein (BSP). Binding studies with isolated ligandin indicated that the affinity of ligandin for phalloidin is low (KD = 0.8 X 10-3 M). Phalloidin neither displaced BSP (KD = 1.
K, Ziegler +3 more
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Amatoxin and phallotoxin concentration inAmanita bisporigeraspores
Mycologia, 2010Even though amatoxins and phallotoxins have been well characterized in basidiocarps of Amanita species, to our knowledge no report of these toxins in spores of Amanitas has been published. Reversed phase HPLC was used to determine non-zero concentrations of alpha-amanitin (0.30 mg/g), and phallacidin (0.02 mg/g) in spores taken from white Amanita sect.
Tristan A, Mcknight +2 more
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Preservation and phallotoxin-staining of the microfilament system in Amoeba proteus
Cell Biology International Reports, 1984The spatial organization of the microfilament system as the main component of the cytoskeleton in Amoeba proteus was preserved by a glutaraldehyde-lysine-fixation and visualized with fluorescent phallotoxins (NBD- phallacidin , R-phalloidin). Results obtained by means of this method coincide exactly with observations gained from immunocytochemical ...
W, Stockem +2 more
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Toxin content, phallotoxin and amatoxin composition of Amanita phalloides tissues
Toxicon, 1993The toxin content and composition of Amanita phalloides tissues were determined in three specimens at two carpophore development stages. The carpophore was subdivided into six parts, namely, the cap, gills, ring, stipe, volva and bulb. To our knowledge, this is the first report of such an investigation on the ring and the bulb.
F, Enjalbert +3 more
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The Chemistry of the Amatoxins, Phallotoxins and Virotoxins
1986Chemical work in Amanita research consisted in the separation and purification of the toxicologically active components of the mushrooms as well as of antamanide and the other cycloamanides, and, lastly, of the hemolytic phallolysin. In this chapter, the chemistry of the toxic cyclopeptides will be described. The procedures for separation and isolation
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Solid State and Solution Conformation of [Ala7]-Phalloidin: A Synthetic Phallotoxin Analogue
Chemistry, 2001Phallotoxins are toxic compounds produced by poisonous mushroom Amanita phalloides and belong to the class of bicyclic peptides with a transannular thioether bridge. Their intoxication mechanism in the liver involves a specific binding of the toxins to F-actin that, consequently, prevents the depolymerization equilibrium with G-actin.
Zanotti Giancarlo +6 more
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Reduced phallotoxin uptake by livers of young compared with adult rats
Naunyn-Schmiedeberg's Archives of Pharmacology, 1979Using [3H]-demethylphalloin as a tracer the uptake of phallotoxins by the liver of young (6, 12, 16 days old) and adult rats was determined in relation to the dose of toxin administered. The maximum amount taken up by the livers of the young rats was only about 50% of that in adults.
Walli , A. +3 more
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Phallotoxin-visualization of F-actin in normal and chromium-poisoned cells
Cell Biology International Reports, 1984The presence of F-actin in Euglena cells was revealed by the use of fluorescent delta-aminophalloin. In normal cells F-actin forms a web of fine filaments at the cell periphery and around the nucleus. In Cr-poisoned cells this pattern is completely altered, and F-actin is visible as a single strongly fluorescent band of various shape and location.
M, Bassi, A, Donini
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