Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry [PDF]
Scientific ReportsAnalysis of amatoxins is of great importance as these cyclic peptides contribute to a high number of fatalities each year. Development of analytical approaches needs to focus on rapid, sensitive, and reliable methods.
Aline C Vollmer +2 more
exaly +6 more sources
Rapid, Sensitive, and Accurate Point-of-Care Detection of Lethal Amatoxins in Urine [PDF]
Toxins, 2020 Globally, mushroom poisonings cause about 100 human deaths each year, with thousands of people requiring medical assistance. Dogs are also susceptible to mushroom poisonings and require medical assistance.
Candace S Bever +2 more
exaly +4 more sources
Comprehensive Clinical Profile of Amanita exitialis Poisoning: Integrating Toxin Detection and Autopsy Pathology [PDF]
ToxinsAmanita exitialis is a lethal mushroom species found in southern China. Its amatoxins can cause acute liver injury with a high case-fatality rate. However, reports combining toxin detection in clinical specimens with autopsy pathology remain limited.
Chong-Gui Chen +10 more
doaj +2 more sources
Serum metabolomics identifies novel prognostic biomarkers in amanita poisoning [PDF]
Frontiers in PharmacologyBackgroundAmanita poisoning causes 90%–95% of global mushroom-related deaths, yet early prognostic biomarkers for Amanita poisoning are lacking.Methods33 patients with Amanita poisoning were recruited and categorized into survival and death group ...
Dan Zhu +6 more
doaj +2 more sources
Analytical methods for amatoxins: A comprehensive review
Journal of Pharmaceutical and Biomedical Analysis, 2023 Amatoxins are toxic bicyclic octapeptides found in certain wild mushroom species, particularly Amanita phalloides. These mushrooms contain predominantly α- and β-amanitin, which can lead to severe health risks for humans and animals if ingested.
Catia Domingues +2 more
exaly +3 more sources
Exploring fungal RiPPs from the perspective of chemical ecology [PDF]
Fungal Biology and Biotechnology, 2022 Since the initial detection, in 2007, of fungal ribosomally synthesised and post-translationally modified peptides (RiPPs), this group of natural products has undergone rapid expansion, with four separate classes now recognised: amatoxins/phallotoxins ...
R. E. Ford, G. D. Foster, A. M. Bailey
doaj +2 more sources
Toxin Profiling of Amanita citrina and A. sinocitrina: First Report of Buiotenine Detection [PDF]
ToxinsAmanita species are widely distributed worldwide. Many of these species are poisonous and can cause health problems, resulting in morbidity and mortality.
Yi-Zhe Zhang +7 more
doaj +2 more sources
Breast milk-associated mushroom poisoning in a toddler: a case report [PDF]
BMC PediatricsBackground Mushroom poisoning represents a significant global public health concern, particularly in endemic regions with abundant wild mushroom resources.
XueJiao Miao +3 more
doaj +2 more sources
Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology
Beilstein Journal of Organic Chemistry, 2012 Phallotoxins inhibit the dynamics of microfilaments in cells and lead to apoptosis. Due to poor cellular uptake these effects cannot be studied in live cells, even at millimolar toxin concentrations, nor can phalloidin be used for the elimination of ...
Hartmut Echner, Heinz Faulstich
exaly +2 more sources
The most dreadful mushroom toxins [PDF]
EXCLI Journal : Experimental and Clinical SciencesMushroom consumption is a worldwide custom that continues to grow in popularity. On the other hand, foraging for wild mushrooms can lead to serious disease and even death if deadly mushrooms are accidentally consumed.
Irene Gouvinhas +3 more
doaj +2 more sources