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Combined Target-Immobilized and Library-Immobilized SELEX for Selecting High-Affinity α-Amanitin Aptamers [PDF]

Toxins
Deaths from the accidental ingestion of poisonous Amanita mushrooms occur every year due to the lack of a specific antidote against α-amanitin poisoning.
Yang Li, Muling Shi, Wenyue Li, Yiqing Yang, Xiang Li, Chen Shen, Xiong Wang, Shuanglin Zhang, Jie Du   +8 more
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Integrating Network Toxicology and Untargeted Metabolomics to Identify Candidate Mechanisms and Metabolic Markers of α-Amanitin-Induced Hepatorenal Injury in Mice [PDF]

Metabolites
Background/Objectives: Mushroom poisoning is a leading cause of death from foodborne illness, and α-amanitin is its most potent toxin. However, the mechanisms and biomarkers of α-amanitin-induced hepatorenal injury remain inadequately understood. Methods:
Haiyan Cui, Yue Guo, Wang Xin, Dan Shao, Meng Hu, Tao Wang, Dan Zhang, Zhiwen Wei, Keming Yun   +8 more
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Mushroom Volatile Compounds Mediate Avoidance Behavior in a Mycophagous Slug and Differential Responses in Drosophila Flies [PDF]

Animals
Volatile organic compounds (VOCs) emitted by mushrooms may influence interactions with animal consumers, yet the roles of individual compounds and their mixtures remain poorly understood.
Keiko Kitabayashi, Yuri Nishiwaki-Akine, Nobuko Tuno   +2 more
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Case Report: α-amanitin toxicosis leading to acute death in a puppy [PDF]

Frontiers in Veterinary Science
A 12-week-old, male intact, Shetland Sheepdog presented with acute onset vomiting and diarrhea, rapidly progressing to stupor and hypoglycemic shock following ingestion of α-amanitin-containing mushrooms. Despite aggressive therapeutic interventions, the
Zachary Lake, Tasia Ludwik, Caylie Hake
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Investigation of In Vitro and In Vivo Metabolism of α-Amanitin in Rats Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method

Molecules, 2022
The purpose of this study is to investigate the difference of in vitro–in vivo correlation of α-amanitin from clearance perspectives as well as to explore the possibility of extra-hepatic metabolism of α-amanitin.
Jiyu Lee, Byeong ill Lee, Jangmi Choi, Yuri Park, Seo-Jin Park, Minjae Park, Jeong-Hyeon Lim, Sangsoo Hwang, Jeong-Min Lee, Young G. Shin   +9 more
doaj   +1 more source

Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury

Metabolites, 2023
α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng, Shaofang Lv, Jianfang Ye, Lu Zou, Kai Zhu, Haichang Li, Yongxi Dong, Lei Li   +7 more
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Utilizing the DNA Aptamer to Determine Lethal α-Amanitin in Mushroom Samples and Urine by Magnetic Bead-ELISA (MELISA)

Molecules, 2022
Amanita poisoning is one of the most deadly types of mushroom poisoning. α-Amanitin is the main lethal toxin in amanita, and the human-lethal dose is about 0.1 mg/kg.
Jiale Gao, Nuoya Liu, Xiaomeng Zhang, En Yang, Yuzhu Song, Jinyang Zhang, Qinqin Han   +6 more
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Toxicokinetics of β-Amanitin in Mice and In Vitro Drug–Drug Interaction Potential

Pharmaceutics, 2022
The toxicokinetics of β-amanitin, a toxic bicyclic octapeptide present abundantly in Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral administration.
Young Yoon Bang, Im-Sook Song, Min Seo Lee, Chang Ho Lim, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee   +7 more
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Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity

Nature Communications, 2023
The “death cap”, Amanita phalloides, is the world’s most poisonous mushroom, responsible for 90% of mushroom-related fatalities. The most fatal component of the death cap is α-amanitin.
Bei Wang, Arabella H. Wan, Yu Xu, Ruo-Xin Zhang, Ben-Chi Zhao, Xin-Yuan Zhao, Yan-Chuan Shi, Xiaolei Zhang, Yongbo Xue, Yong Luo, Yinyue Deng, G. Gregory Neely, Guohui Wan, Qiao-Ping Wang   +13 more
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Differential Expression of Amanitin Biosynthetic Genes and Novel Cyclic Peptides in Amanita molliuscula

Journal of Fungi, 2021
Amanita molliuscula is a basal species of lethal Amanita and intrigues the field because it does not produce discernable α-amanitin when inspected by High Performance Liquid Chromatography (HPLC), which sets it apart from all known amanitin-producing ...
Yunjiao Lüli, Shengwen Zhou, Xuan Li, Zuohong Chen, Zhuliang Yang, Hong Luo   +5 more
doaj   +1 more source