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Combined Target-Immobilized and Library-Immobilized SELEX for Selecting High-Affinity α-Amanitin Aptamers [PDF]
ToxinsDeaths from the accidental ingestion of poisonous Amanita mushrooms occur every year due to the lack of a specific antidote against α-amanitin poisoning.
Yang Li +8 more
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Metabolites, 2023 α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng +7 more
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Toxicokinetics of β-Amanitin in Mice and In Vitro Drug–Drug Interaction Potential
Pharmaceutics, 2022 The toxicokinetics of β-amanitin, a toxic bicyclic octapeptide present abundantly in Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral administration.
Young Yoon Bang +7 more
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Molecules, 2022 Amanita poisoning is one of the most deadly types of mushroom poisoning. α-Amanitin is the main lethal toxin in amanita, and the human-lethal dose is about 0.1 mg/kg.
Jiale Gao +6 more
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Case Report: α-amanitin toxicosis leading to acute death in a puppy [PDF]
Frontiers in Veterinary ScienceA 12-week-old, male intact, Shetland Sheepdog presented with acute onset vomiting and diarrhea, rapidly progressing to stupor and hypoglycemic shock following ingestion of α-amanitin-containing mushrooms. Despite aggressive therapeutic interventions, the
Zachary Lake, Tasia Ludwik, Caylie Hake
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Mushroom Volatile Compounds Mediate Avoidance Behavior in a Mycophagous Slug and Differential Responses in Drosophila Flies [PDF]
AnimalsVolatile organic compounds (VOCs) emitted by mushrooms may influence interactions with animal consumers, yet the roles of individual compounds and their mixtures remain poorly understood.
Keiko Kitabayashi +2 more
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Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry [PDF]
Scientific ReportsAnalysis of amatoxins is of great importance as these cyclic peptides contribute to a high number of fatalities each year. Development of analytical approaches needs to focus on rapid, sensitive, and reliable methods.
Aline C. Vollmer +5 more
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Molecules, 2022 The purpose of this study is to investigate the difference of in vitro–in vivo correlation of α-amanitin from clearance perspectives as well as to explore the possibility of extra-hepatic metabolism of α-amanitin.
Jiyu Lee +9 more
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Journal of Fungi, 2021 Amanita molliuscula is a basal species of lethal Amanita and intrigues the field because it does not produce discernable α-amanitin when inspected by High Performance Liquid Chromatography (HPLC), which sets it apart from all known amanitin-producing ...
Yunjiao Lüli +5 more
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Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity
Nature Communications, 2023 The “death cap”, Amanita phalloides, is the world’s most poisonous mushroom, responsible for 90% of mushroom-related fatalities. The most fatal component of the death cap is α-amanitin.
Bei Wang +13 more
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