Results 31 to 40 of about 8,493 (176)

Detection and analysis of amatoxins in 3 species of Lepiota from Chuxiong, Yunnan Province

Zhongguo shipin weisheng zazhi
ObjectiveTo analyze the content of 6 kinds of amatoxins in 3 species of Lepiota collected from Chuxiong of Yunnan Province.MethodsThe collected mushrooms were baked and dried at 45 ℃， and species identification was carried out by morphological and ...
XU Ping, YU Chengmin, YAO Qunmei, LI Jipin, TANG Yan, WU Zhaohua, ZHONG Jiaju   +6 more
doaj   +1 more source

Antiproliferative Effect of pHLIP-Amanitin

Biochemistry, 2013
Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer ...
Moshnikova, Anna, Moshnikova, Valentina, Andreev, Oleg A., Reshetnyak, Yana   +3 more
openaire   +4 more sources

The Role of Ferroptosis in Hepatocyte Injury Induced by α-Amanitin

Fayixue Zazhi
ObjectiveTo explore whether ferroptosis is involved in α-amanitin-induced hepatocyte injury by detecting iron deposition in mice liver tissues, oxidative stress indicators in hepatocytes and L-02 cells, and expressions of ferroptosis-related proteins ...
WANG Hao-wei, ZHANG Xiao-xing, YANG Gen-meng, WANG Shang-wen, ZENG Xiao-feng   +4 more
doaj   +1 more source

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

Beilstein Journal of Organic Chemistry, 2018
RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 ...
Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli   +9 more
doaj   +1 more source

Investigation of a mushroom poisoning incident caused by Amanita fuliginea in Guizhou Province

Zhongguo shipin weisheng zazhi, 2023
ObjectiveTo provide support and reference for the diagnosis， investigation， laboratory testing， and prevention of toxic mushroom poisoning in Guizhou， an Amanita fuliginea poisoning incident in Bijie， Guizhou Province was investigated.MethodsAn ...
ZHU Shu, GUO Hua, ZHOU Yajuan, YANG Longjian, ZHOU Yibing   +4 more
doaj   +1 more source

GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets. [PDF]

Adv Sci (Weinh)
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wu W, Jiang H, Liu Y, Peng C, Wang H, Yang W, Lyu Z, Sun Y, Ma H, Gu H, Kan W, Jing L, Dong T, Xia C, Lei S, Wu R, Li J, Li J.   +17 more
europepmc   +2 more sources

Amanitin intoxication

Clinical Toxicology, 2022
BACKGROUND AND AIMS: Amanita phalloides poisoning causes severe liver damage which may be potentially fatal. Several treatments are available, but their effectiveness has not been systematically evaluated. We performed a systematic review to investigate the effect of the most commonly used therapies: N-acetylcysteine (NAC), benzylpenicillin (PEN), and ...
Tan, Jia Lin, Stam, Janine, van den Berg, Aad P, van Rheenen, Patrick F, Dekkers, Bart G J, Touw, Daan J   +5 more
openaire   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Deadly Poisonous Turkish Mushrooms Containing Alpha Amanitin [PDF]

Düzce Tıp Fakültesi Dergisi, 2015
Mushroom poisoning is still a serious health problem for Turkey. The mushroom species which cause fatal mushroom poisoning have been reported to contain at least 98% alpha-amanitin.
Ilgaz Akata, Ertuğrul Kaya, İsmail Yılmaz, et al.   +3 more
doaj  

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source