Results 41 to 50 of about 8,493 (176)
Zhongguo shipin weisheng zazhi, 2022 ObjectiveTo establish an analytical method for 9 mushroom toxins in wild fungus by liquid chromatography-tandem mass spectrometry （LC-MS/MS） including 5 acute liver failure toxins （α-amanitin， β-amanitin， γ-amanitin， phallacidin and phalloidin） and 4 ...
XU Xiaomin +5 more
doaj +1 more source
British Journal of Haematology, EarlyView.Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation
Ecotoxicology and Environmental SafetyMushroom poisoning, predominantly caused by α-amanitin, is a critical food safety concern in worldwide, with severe cases leading to hepatotoxicity and fatalities.
Haowei Wang +9 more
doaj +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Toxins, 2018 One of the deadliest mushrooms is the death cap mushroom, Amanita phalloides. The most toxic constituent is α-amanitin, a bicyclic octapeptide, which damages the liver and kidneys.
Candace S. Bever +4 more
doaj +1 more source
Viroid‐Derived siRNAs: Minimal RNAs Driving Multiscale Perturbations of Host Regulatory Systems
WIREs RNA, Volume 17, Issue 5, September/October 2026.Tiny circular RNAs known as viroids can profoundly reshape plant biology without encoding proteins. Through the production of regulatory small RNAs, they translate RNA structure into signals that connect molecular interactions with systemic disease outcomes.
Katia Aviña‐Padilla +4 more
wiley +1 more source
Toxicon, 2022 Amanitin poisoning still has no particular, effective antidote. Erdosteine has been shown to protect numerous tissues, particularly those in the liver. This study investigates the potential therapeutic effects of erdosteine on alpha-, beta- and gamma-amanitin-induced hepatotoxicity in in vitro models.
Recep Bayram +3 more
openaire +3 more sources
The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.
PLoS ONE, 2014 The rapid evolution of toxin resistance in animals has important consequences for the ecology of species and our economy. Pesticide resistance in insects has been a subject of intensive study; however, very little is known about how Drosophila species ...
Chelsea L Mitchell +4 more
doaj +1 more source
The occurrence of ansamers in the synthesis of cyclic peptides
Nature Communications, 2022 The occurrence of isomers of the bicyclic octapeptide α-amanitin, which presents a macrolactam with a tryptathionine cross-link forming a handle, has been reported under the term of atropoisomers.
Guiyang Yao +6 more
doaj +1 more source