Results 1 to 10 of about 117 (89)
Molecules, 2022 The purpose of this study is to investigate the difference of in vitro–in vivo correlation of α-amanitin from clearance perspectives as well as to explore the possibility of extra-hepatic metabolism of α-amanitin.
Jiyu Lee +9 more
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Metabolites, 2023 α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng +7 more
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Molecules, 2022 Amanita poisoning is one of the most deadly types of mushroom poisoning. α-Amanitin is the main lethal toxin in amanita, and the human-lethal dose is about 0.1 mg/kg.
Jiale Gao +6 more
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Protective effect of ganoderma acid A on liver injury induced by α-amanitin in mice
Zhongguo gonggong weisheng, 2023 ObjectiveTo investigate the protective mechanism of ganoderma acid A against α-amanitin-induced liver injury in mice. MethodsForty Kunming mice were divided into 4 groups intraperitoneally injected with solution (10 mL/kg) containing α-amanitin at ...
Lei LI, Yongting LIU, Chong ZHENG
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Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity
Nature Communications, 2023 The “death cap”, Amanita phalloides, is the world’s most poisonous mushroom, responsible for 90% of mushroom-related fatalities. The most fatal component of the death cap is α-amanitin.
Bei Wang +13 more
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Journal of Fungi, 2021 Amanita molliuscula is a basal species of lethal Amanita and intrigues the field because it does not produce discernable α-amanitin when inspected by High Performance Liquid Chromatography (HPLC), which sets it apart from all known amanitin-producing ...
Yunjiao Lüli +5 more
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Toxicity and urinary metabolites of α-amanitin in mice
Zhongguo gonggong weisheng, 2022 ObjectiveTo explore toxicity and urinary metabolites of α-amanitin in mice with a 21-day toxicological experiment. MethodsTwenty ICR male mice were randomly divided into a control (n = 5) and three median lethal dose (LD50) groups (5 in each group) with ...
Zhi-jun WU, Wen-jin ZHAO, Hai-jiao LI
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α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. [PDF]
PLoS ONE, 2017 We investigated the mechanisms of mushroom toxin resistance in the Drosophila Genetic Reference Panel (DGRP) fly lines, using genome-wide association studies (GWAS).
Chelsea L Mitchell +13 more
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Foods, 2022 Mushroom poisoning remains a serious food safety and health concern in some parts of the world due to its morbidity and mortality. Identification of mushroom toxins at an early stage of suspected intoxication is crucial for a rapid therapeutic decision ...
Isabel Barbosa +3 more
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Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
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