Results 41 to 50 of about 4,007 (118)

Fast determination of 9 mushroom toxins in wild fungus by liquid chromatography-tandem mass spectrometry

open access: yesZhongguo shipin weisheng zazhi, 2022
ObjectiveTo establish an analytical method for 9 mushroom toxins in wild fungus by liquid chromatography-tandem mass spectrometry (LC-MS/MS) including 5 acute liver failure toxins (α-amanitin, β-amanitin, γ-amanitin, phallacidin and phalloidin) and 4 ...
XU Xiaomin   +5 more
doaj   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde   +4 more
wiley   +1 more source

α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation

open access: yesEcotoxicology and Environmental Safety
Mushroom poisoning, predominantly caused by α-amanitin, is a critical food safety concern in worldwide, with severe cases leading to hepatotoxicity and fatalities.
Haowei Wang   +9 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin   +2 more
wiley   +1 more source

Investigation and analysis of a poisoning incident caused by Amanita exitialis in Meizhou

open access: yesZhongguo shipin weisheng zazhi, 2023
ObjectiveTo investigate a mushroom poisoning incident in Meizhou City, Guangdong Province in 2022, and provide a scientific basis for the prevention and control measures.MethodsEpidemiological investigations were carried out on the causes of poisoning ...
HU Bei   +8 more
doaj   +1 more source

Transcription and Three‐Dimensional Genome Organization: Cause, Consequence, or Coordination?

open access: yesBioEssays, Volume 48, Issue 9, September 2026.
Transcription and 3D genome organization influence each other across spatial scales. Large‐scale architecture provides a relatively stable framework, while transcription and shared architectural factors refine local chromatin loops and domain boundaries. Specific long‐range interactions between regulatory elements and distal anchors can override domain‐
Dagyeong Yang, Elissa P. Lei
wiley   +1 more source

Mushroom ( Amanita phalloides) Poisoning: Mechanisms, Pathogenesis, Prognosis and Strategies of Treatment

open access: yesمجلة علوم ذي قار, 2021
Poisoning due to mushroom consumption is uncommon, but it causes death by causing acute liver failure (ALF). The ingestion of Amanita phalloides, is one of the ultimate frequent causes of mushroom poisoning globally.
Afrah Thiab Hlail
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan   +9 more
wiley   +1 more source

Viroid‐Derived siRNAs: Minimal RNAs Driving Multiscale Perturbations of Host Regulatory Systems

open access: yesWIREs RNA, Volume 17, Issue 5, September/October 2026.
Tiny circular RNAs known as viroids can profoundly reshape plant biology without encoding proteins. Through the production of regulatory small RNAs, they translate RNA structure into signals that connect molecular interactions with systemic disease outcomes.
Katia Aviña‐Padilla   +4 more
wiley   +1 more source

Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass Spectrometry

open access: yesToxins, 2020
Amatoxins are known to be one of the main causes of serious to fatal mushroom intoxication. Thorough treatment, analytical confirmation, or exclusion of amatoxin intake is crucial in the case of any suspected mushroom poisoning.
Thomas P. Bambauer   +3 more
doaj   +1 more source

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