Results 61 to 70 of about 4,007 (118)

A Simple and High-Throughput Analysis of Amatoxins and Phallotoxins in Human Plasma, Serum and Urine Using UPLC-MS/MS Combined with PRiME HLB μElution Platform

Toxins, 2016
Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of fatal food poisoning in China.
Shuo Zhang, Yunfeng Zhao, Haijiao Li, Shuang Zhou, Dawei Chen, Yizhe Zhang, Qunmei Yao, Chengye Sun   +7 more
doaj   +1 more source

Isolable Cysteine Sulfenyl Iodide: Stabilization by a Molecular Cradle, Crystal Structure, and Biologically Relevant Reactivity

ChemBioChem, Volume 26, Issue 24, December 11, 2025.
An isolable cysteine sulfenyl iodide (Cys–SI) stabilized by a molecular cradle is reported. X‐ray analysis and reactivity studies reveal hydrolysis to sulfenic acid, electrophilic substitution with indoles, and high reactivity toward amines and dimedone, providing direct evidence for long‐standing proposals on iodine‐mediated protein modification ...
Shotaro Otaka, Tsukasa Sano, Shohei Sase, Satoru Kuwano, Kei Goto   +4 more
wiley   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, Volume 12, Issue 45, December 4, 2025.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Lost in Translation: Physiological Roles of Stored mRNAs in Seed Germination

Plants, 2020
Seeds characteristics such as germination ability, dormancy, and storability/longevity are important traits in agriculture, and various genes have been identified that are involved in its regulation at the transcriptional and post-transcriptional level ...
Naoto Sano, Loïc Rajjou, Helen M. North   +2 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry

Scientific Reports
Analysis of amatoxins is of great importance as these cyclic peptides contribute to a high number of fatalities each year. Development of analytical approaches needs to focus on rapid, sensitive, and reliable methods.
Aline C. Vollmer, Claudia Fecher-Trost, Candace S. Bever, Christina C. Tam, Lea Wagmann, Markus R. Meyer   +5 more
doaj   +1 more source

A Sensitive, Cell-Based Assay for Measuring Low-Level Biological Activity of α-Amanitin. [PDF]

Int J Mol Sci, 2023
Rasooly R, Do P, He X, Hernlem B.
europepmc   +1 more source

Simultaneous Determination of Multi-Class Mushroom Toxins in Mushroom and Biological Liquid Samples Using LC-MS/MS

Separations
A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ ...
Junjia Lu, Jing Zhang, Haijiao Li, Chengye Sun   +3 more
doaj   +1 more source

α-amanitin线性肽骨架融合基因表达条件的优化

四川大学学报. 自然科学版, 2004
利用加端PCR技术在 pGEX 1λT质粒BamHI和PstI位点间 (片段BamHI端 )加入α amanitin线性八肽碳骨架编码序列 ,再将两次连续加端PCR产物连入BamHI、PstI双酶切的pGEX 1λT载体 ,得到含α amanitin线性碳骨架编码序列的阳性重组子pGAT 1 .序列测定和结果分析显示 ,构建的融合基因相位正确 ,阅读框通读 .通过对融合基因在大肠杆菌中表达条件的优化 ,目的融合蛋白的表达量可提高 33.5 %,占总蛋白表达量的 2 8.3%.
赵建, 朱建清, 张杰, 曹玫, 王松涛, 李达旭, 杨志荣   +6 more
doaj  

Molecular characterization and liquid chromatography-mass spectrometric multiple reaction monitoring-based detection in case of suspected phalloides syndrome poisoning

Journal of Associated Medical Sciences, 2018
Backgrounds: The most common lethal mushrooms are invariably attributed to amanitas, which contain several types of lethal peptide toxins. During 2015 to 2018, the suspect in phalloides syndrome case reported to the Thai National Institute of Health ...
Sathaporn Ramchiun, Sujitra Sikaphan, Siriwan Leudang, Dutsadee Polputpisatkul, Nattaphong Nantachaiphong, Thitima Khaentaw, Nattakarn Nooron, Chutimon Uttawichai, Sittiporn Parnmen   +8 more
doaj