Results 61 to 70 of about 732,445 (126)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 2, February 2026.ABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Fuping Lai +8 more
wiley +1 more source
Phosphorylation Status of RNA Polymerase II Carboxyl-terminal Domain in Porcine Oocytes and Early Embryos [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Fertilization of the oocyte commences embryogenesis during which maternally inherited mRNAs are degraded and the embryonic genome is activated. Transcription of embryonic mRNA is initiated by embryonic genome activation (EGA).
Reza K. Oqani +4 more
doaj +1 more source
ChemBioChem, Volume 26, Issue 24, December 11, 2025.An isolable cysteine sulfenyl iodide (Cys–SI) stabilized by a molecular cradle is reported. X‐ray analysis and reactivity studies reveal hydrolysis to sulfenic acid, electrophilic substitution with indoles, and high reactivity toward amines and dimedone, providing direct evidence for long‐standing proposals on iodine‐mediated protein modification ...
Shotaro Otaka +4 more
wiley +1 more source
Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α‑Amanitin [PDF]
The ability of α-amanitin to potently inhibit RNA polymerase II (RNAP II) has elicited further research into its use as a novel payload for antibody-drug conjugates.
Tsung-Han Chao (3423773) +1 more
core +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu +17 more
wiley +1 more source
Cell Division in the Presence of RNA Polymerase II Inhibitor α-Amanitin [PDF]
, 2013 (A) α-Amanitin 10 μM was added to 12:12 light/dark synchronized wild-type cells at 9 h in the light period (vertical arrow), and the drug-treated or control cultures were dark-shifted at 10 h.
Su-Chiung Fang (274532) +2 more
core +1 more source
PLoS ONE, 2017 Amanita ballerina and A. brunneitoxicaria spp. nov. are introduced from Thailand. Amanita fuligineoides is also reported for the first time from Thailand, increasing the known distribution of this taxon.
Benjarong Thongbai +6 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
Ama-KTT/M/2 is not less resistant to α-amanitin than Ama-KTT. [PDF]
, 2014 Ten first-instar larvae were placed on each α-amanitin concentration. The dose response curve shows the percentage of hatching flies. Error bars indicate the s.e.m. of three replicates.
Liang Lei (220238) +4 more
core +1 more source
MiR‐1 Is Regulated by Hydrogen Peroxide via MAPK and Limits Cell Migration and Invasion
Environmental Toxicology, Volume 40, Issue 11, Page 1249-1260, November 2025.ABSTRACT MicroRNA‐1 (miR‐1) is a conserved microRNA that is highly expressed in skeletal and cardiac muscle tissues. Moreover, miR‐1 regulates genes and has critical roles in cell migration and invasion. Downregulation of miR‐1 has been found in many pathologies of numerous organs, including the lungs.
Maricica Pacurari +2 more
wiley +1 more source