Results 71 to 80 of about 732,445 (126)
Study on genes with altered expression in α-amanitin poisoned mice and evaluation on antagonistic effects of traditional Chinese medicines against toxicity of α-amanitin [PDF]
The forward and reverse cDNA subtractive libraries before and after the toxic effect of α-amanitin were constructed by suppression subtractive hybridization and randomly selected clones from each subtractive library were screened by PCR and dot blot ...
Hou, R. +9 more
core +1 more source
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution [PDF]
, 2002 The structure of RNA polymerase II in a complex with the inhibitor α-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription ...
Bushnell, D. A. +5 more
core +1 more source
Journal of Food Science, Volume 90, Issue 11, November 2025.ABSTRACT Food contamination poses a significant global health threat with carcinogenic potential, though the molecular pathways connecting contaminants to cancer remain poorly understood. This study sought to identify key molecular targets mediating the carcinogenic effects of nine prevalent dietary contaminants: glyphosate, perfluorooctane sulfonate ...
Bangsheng Chen +7 more
wiley +1 more source
Distribution of fluorescent α-amanitin (FAMA) during mitosis in cultured rat kangaroo (PtK1) cells [PDF]
, 1980 The mushroom toxin α-amanitin is known to possess a high affinity to eukaryotic RNA polymerase II (or B) [1–3]. To pursue the question where these enzymes are located during mitosis of cells, a fluorescent derivative of α-amanitin (FAMA) was prepared ...
Faulstich, H. +3 more
core +1 more source
BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly [PDF]
, 2019 Despite the great success of small molecule inhibitors in the treatment of patients with BRAF mutated melanoma, the response to these drugs remains transient and patients eventually relapse within a few months, highlighting the need to develop novel ...
Britschgi, Christian +7 more
core +1 more source
An explicit-solvent conformation search method using open software [PDF]
PeerJ, 2016 Computer modeling is a popular tool to identify the most-probable conformers of a molecule. Although the solvent can have a large effect on the stability of a conformation, many popular conformational search methods are only capable of describing ...
Kari Gaalswyk, Christopher N. Rowley
doaj +2 more sources
Nucleolar Organization in Response to Transcriptional Stress
Cancer Science, Volume 116, Issue 10, Page 2649-2656, October 2025.In this review, we provide an overview of the research field on nucleolar regulation, mainly focusing on nucleolar organization under transcriptional stress. We also highlight the importance of ribosomal DNA stability, particularly in disease prevention, including cancer.
Rikiya Imamura, Takaaki Yasuhara
wiley +1 more source
Toxins, 2016 Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of fatal food poisoning in China.
Shuo Zhang +7 more
doaj +1 more source
The FASEB Journal, Volume 39, Issue 17, 15 September 2025.A mouse model of Tfam conditional knock‐out (TfamloxP/loxP; Zp3‐Cre) produces mtDNA‐depleted eggs. An abundance of mitochondrial mass is maintained through fission during oocyte growth and enables egg fertilization and blastocyst formation. Although embryonic genome activation may compensate for the maternal knock‐out in the two‐cell stage, the ...
Miki Shavit +11 more
wiley +1 more source
Nature Communications, 2018 Heterozygous loss of chromosome 17p is a common genomic event in castration-resistant prostate cancers (CRPC). Here, the authors use CRISPR-based screen to identify RBX1 as a target gene for CRPC with 17p loss and targeting RBX1 sensitizes CRPC to the ...
Yujing Li +21 more
doaj +1 more source