Effect of gut microbiota on α-amanitin tolerance in Drosophila tripunctata. [PDF]
Ecol Evol, 2020 The bacterial gut microbiota of many animals is known to be important for many physiological functions including detoxification. The selective pressures imposed on insects by exposure to toxins may also be selective pressures on their symbiotic bacteria,
Griffin LH, Reed LK.
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The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. [PDF]
PLoS One, 2014 The rapid evolution of toxin resistance in animals has important consequences for the ecology of species and our economy. Pesticide resistance in insects has been a subject of intensive study; however, very little is known about how Drosophila species ...
Mitchell CL +4 more
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First Report of a Neotropical Agaric (Lepiota spiculata, Agaricales, Basidiomycota) Containing Lethal α-Amanitin at Toxicologically Relevant Levels. [PDF]
Front Microbiol, 2020 A recent collection of Lepiota spiculata from the Dominican Republic is presented here. Macro- and micromorphological features of L. spiculata are described in detail, and its evolutionary (phylogenetic) position within Lepiota sect.
Angelini C +5 more
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Posaconazole mitigates α-amanitin-induced liver injury by inhibiting STT3B-mediated glycosylation and cellular uptake. [PDF]
Front PharmacolBackgroundMushroom poisoning caused by Amanita phalloides, primarily mediated by the toxin α-amanitin (AMA), frequently leads to fatal liver failure, yet no specific antidote is currently available. Although AMA is known to inhibit RNA polymerase II, its
Wang B +9 more
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Mushroom Volatile Compounds Mediate Avoidance Behavior in a Mycophagous Slug and Differential Responses in <i>Drosophila</i> Flies. [PDF]
Animals (Basel)Volatile organic compounds (VOCs) emitted by mushrooms may influence interactions with animal consumers, yet the roles of individual compounds and their mixtures remain poorly understood.
Kitabayashi K +2 more
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A Convergent Total Synthesis of the Death Cap Toxin α-Amanitin [PDF]
Angewandte Chemie - International Edition, 2020 Roderich D. Süssmuth +1 more
exaly +2 more sources
Comprehensive Clinical Profile of <i>Amanita exitialis</i> Poisoning: Integrating Toxin Detection and Autopsy Pathology. [PDF]
Toxins (Basel)Amanita exitialis is a lethal mushroom species found in southern China. Its amatoxins can cause acute liver injury with a high case-fatality rate. However, reports combining toxin detection in clinical specimens with autopsy pathology remain limited.
Chen CG +10 more
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Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
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α-AMA induced liver failure is associated with elevation of HMGB1 lactylation modification in mice. [PDF]
BMC GastroenterolBackground Acute liver failure (ALF) induced by poisonous mushrooms represents the most significant threat to humans from mushroom poisoning, primarily attributable to α-amanitin (α-AMA).
Huang S +5 more
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Protective effect of ganoderma acid A on liver injury induced by α-amanitin in mice
Zhongguo gonggong weisheng, 2023 ObjectiveTo investigate the protective mechanism of ganoderma acid A against α-amanitin-induced liver injury in mice. MethodsForty Kunming mice were divided into 4 groups intraperitoneally injected with solution (10 mL/kg) containing α-amanitin at ...
Lei LI, Yongting LIU, Chong ZHENG
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