Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells [PDF]
ToxinsAmanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloides, α-
Willemien F. J. Hof +7 more
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The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. [PDF]
PLoS ONE, 2014 The rapid evolution of toxin resistance in animals has important consequences for the ecology of species and our economy. Pesticide resistance in insects has been a subject of intensive study; however, very little is known about how Drosophila species ...
Chelsea L Mitchell +4 more
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Case Report: α-amanitin toxicosis leading to acute death in a puppy [PDF]
Frontiers in Veterinary ScienceA 12-week-old, male intact, Shetland Sheepdog presented with acute onset vomiting and diarrhea, rapidly progressing to stupor and hypoglycemic shock following ingestion of α-amanitin-containing mushrooms. Despite aggressive therapeutic interventions, the
Zachary Lake, Tasia Ludwik, Caylie Hake
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Synthesis of the Death-Cap Mushroom Toxin α‑Amanitin [PDF]
, 2018 α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells.
Kaveh Matinkhoo (4990370) +4 more
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In vivo and in vitro α-amanitin metabolism studies using molecular networking [PDF]
, 2021 International audienceAmanitin poisonings are among the most life-threatening mushroom poisonings, and are mainly caused by the genus Amanita. Hepatotoxicity is the hallmark of amanitins, powerful toxins contained in these mushrooms, and can require ...
Gicquel, Thomas +5 more
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Calculating RNA degradation rates using large-scale normalization in mouse embryonic stem cells
STAR Protocols, 2023 Summary: Data normalization is critical to the process of estimating RNA degradation by analyzing RNA levels when transcription is blocked. Here, we present a protocol for measuring mRNA degradation rates, optimized for mouse embryonic stem cells, using ...
Juliane Oliveira Viegas +3 more
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Treatment with α–amanitin. [PDF]
, 2013 LB cells were treated for 24h with α–amanitin with or without DFO treatment. (A) Relative quantification of mRNA. mRNA was quantified relatively to the non-treated sample which was set as 1.
Ninette Amariglio (10560) +3 more
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Prolonged α-amanitin treatment of cells for studying mutated polymerases causes degradation of DSIF160 and other proteins [PDF]
, 2012 A useful method for studying the function of the mammalian RNA polymerase II takes advantage of the extreme sensitivity of its largest subunit, Rpb1, to α-amanitin.
Martinson, Harold G. +3 more
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Hemoperfusion with α-Amanitin: An in Vitro Study [PDF]
, 1997 The authors carried out sixteen hemoperfusions with α-amanitin in vitro in a closed system using active charcoal, Amberlite XAD-2 and Amberlite XAD-4 in hemoperfusion capsules. As a perfusion solution 4 liters of 0.9% NaCl solution was used.
M. Mydlík +3 more
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The structure of α‐amanitin in dimethylsulfoxide solution [PDF]
, 1978 The backbone and side‐chain conformations of the bicyclic octapeptide α‐amanitin indimethylsulfoxide (DMSO) solution have ben deduced from analysis of the nmr spectrl parameters and conformational energy calculations.
Tonelli, A. +3 more
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