Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury [PDF]
Scientific ReportsAs one of the most toxic molecules in the fungal kingdom, amatoxin exhibit exceptional thermal stability and acid resistance. Once ingested, these compounds are rapidly absorbed and transported unimpeded to vital organs.
Yingchun Hu, Yaxing Deng
exaly +3 more sources
Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series
Toxicology Communications, 2022 Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alpha-amanitin, the
Emily B Austin +2 more
exaly +3 more sources
Should Every Symptomatic Patient with Mushroom Poisoning Be Monitored in the Intensive Care Unit?—A Retrospective Observational Study [PDF]
ToxinsA rapid method for the early diagnosis of fatal mushroom poisoning is not available. Therefore, in our region, symptomatic patients are admitted to intensive care units (ICUs) for close monitoring and treatment.
Duygu Kayar Calili +3 more
doaj +2 more sources
Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry [PDF]
Scientific ReportsAnalysis of amatoxins is of great importance as these cyclic peptides contribute to a high number of fatalities each year. Development of analytical approaches needs to focus on rapid, sensitive, and reliable methods.
Aline C. Vollmer +5 more
doaj +2 more sources
Comprehensive Clinical Profile of Amanita exitialis Poisoning: Integrating Toxin Detection and Autopsy Pathology [PDF]
ToxinsAmanita exitialis is a lethal mushroom species found in southern China. Its amatoxins can cause acute liver injury with a high case-fatality rate. However, reports combining toxin detection in clinical specimens with autopsy pathology remain limited.
Chong-Gui Chen +10 more
doaj +2 more sources
Amatoxin Intoxication and Wild Mushroom Poisoning: Current Advances in Diagnosis, Risk Stratification, and Clinical Management [PDF]
ToxinsWild mushroom poisoning remains a major medical and toxicological challenge worldwide because of the diversity of toxic compounds, the broad spectrum of clinical manifestations, and the risk of severe hepatic or renal injury.
Tsonka Dimitrova +5 more
doaj +2 more sources
Mushroom poisoning: An updated review [PDF]
Turkish Journal of Emergency MedicineMushrooms have been consumed frequently worldwide since ancient times. In addition to edible and harmless species, there are also poisonous species that cause a wide range of clinical syndromes, from simple gastrointestinal (GI) irritation to death ...
Mustafa Oğuz Tuğcan +1 more
doaj +2 more sources
Amanitins: The Most Poisonous Molecules of the Fungal World [PDF]
Molecules, 2023 Among the toxic metabolites of the fungal world, those that, due to their strong biological effect, can seriously (even fatally) damage the life processes of humans (and certain groups of animals) stand out.
János Vetter
doaj +2 more sources
Amanitine poisoning - cases, management, therapy results
Journal of Education, Health and Sport, 2023 Mushroom poisoning continues to be a serious clinical problem. The most serious are intoxications with mushrooms containing cytotropic toxins with predominant injury of liver, kidneys and heart. The toxic properties of the phalloides are mainly due to α-
Magdalena Kubicka +5 more
doaj +1 more source
Journal of Family Medicine and Primary Care, 2022 Introduction: Mushroom poisoning occurs from consumption of the wild variants of mushroom containing varied forms of toxins. Among those toxins, amatoxin containing mushrooms are known for the significant morbidity and mortality from hepatic toxicity and
Iadarilang Tiewsoh +6 more
doaj +1 more source