Results 31 to 40 of about 465 (157)

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Nature Communications, 2017
Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase ...
Clarissa M. Czekster, Hannes Ludewig, Stephen A. McMahon, James H. Naismith   +3 more
doaj   +1 more source

Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms.

PLoS ONE, 2020
The mushroom poison that causes the most deaths is the class of toxins known as amatoxins. Current methods to sensitively and selectively detect these toxins are limited by the need for expensive equipment, or they lack accuracy due to cross-reactivity ...
Candace S Bever, Catharine A Adams, Robert M Hnasko, Luisa W Cheng, Larry H Stanker   +4 more
doaj   +1 more source

Acute Liver Failure Caused by Amanita phalloides Poisoning

International Journal of Hepatology, 2012
Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which ...
Luca Santi, Caterina Maggioli, Marianna Mastroroberto, Manuel Tufoni, Lucia Napoli, Paolo Caraceni   +5 more
doaj   +1 more source

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

Application of single-pass albumin dialysis in the acute phase of amanitin syndrome caused by mushroom poisoning [PDF]

Vojnosanitetski Pregled
Introduction. The frequency of mushroom poisoning is increasing both in the world and in our country. The most poisonous type of mushroom in our region is Amanita phalloides, which causes amanitin syndrome in poisoned patients, and it is considered ...
Jovanović Dragana, Pilčević Dejan, Isailović Jelena, Vukčević Perković Nataša, Vuković Rade   +4 more
doaj   +1 more source

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range

New Phytologist, Volume 250, Issue 3, Page 1863-1883, May 2026.
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle   +39 more
wiley   +1 more source

Acute kidney injury related to wild mushrooms intoxication

Journal of Education, Health and Sport, 2020
The problem of mushroom intoxication has been brought up more often in both scientific journals and media, particularly in autumn – the period when mushroom hunting is most intense. Mushroom intoxication is mainly perceived as being associated with acute
Małgorzata Marchelek-Myśliwiec, Aleksandra Wilk, Agnieszka Turoń-Skrzypińska, Monika Nowosiad-Magda, Grazyna Dutkiewicz, Barbara Dołęgowska, Joanna Stępniewska, Kazimierz Ciechanowski, Barbara Wiszniewska   +8 more
doaj   +1 more source

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source

Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimines and Sulfoximines

Angewandte Chemie, Volume 136, Issue 13, March 22, 2024.
Metal‐free, and high‐yielding sulfur‐imination using O‐(diphenylphosphinyl)hydroxyl amine to access sulfilimine salts and free‐NH sulfoximines has been reported. Its generality was evidenced using a broad substrate scope along with late‐stage functionalization of complex, biologically relevant substrates including a notorious amatoxin.
Shanal Gunasekera, Alla Pryyma, Jimin Jung, Rebekah Greenwood, Brian O. Patrick, David M. Perrin   +5 more
wiley   +2 more sources

Early initiation of MARS® dialysis in Amanita phalloides-induced acute liver injury prevents liver transplantation

Annals of Hepatology, 2016
Amanita phalloides is the most relevant mushroom intoxication leading to acute liver failure. The two principal groups of toxins, the amatoxins and the phallotoxins, are small oligopeptides highly resistant to chemical and physical influences.
Mike Hendrik Pillukat, Tina Schomacher, Peter Baier, Gert Gabriëls, Hermann Pavenstädt, Hartmut H.J. Schmidt   +5 more
doaj   +1 more source