Results 31 to 40 of about 443 (153)

Research Progress on the Establishment of Animal Models of Amanita Toxin Poisoning

Journal of Forensic Science and Medicine
Amatoxin is the primary lethal component of highly toxic Amanita species, inducing severe liver failure or even multiple organ failure, with no specific clinical treatments available. Establishing amatoxin poisoning animal models is critical for studying
Haowei Wang, Xinyu Zhang, Teng Sun, Xiaodong Li, Shangwen Wang, Xiaofeng Zeng   +5 more
doaj   +1 more source

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Nature Communications, 2017
Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase ...
Clarissa M. Czekster, Hannes Ludewig, Stephen A. McMahon, James H. Naismith   +3 more
doaj   +1 more source

Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms.

PLoS ONE, 2020
The mushroom poison that causes the most deaths is the class of toxins known as amatoxins. Current methods to sensitively and selectively detect these toxins are limited by the need for expensive equipment, or they lack accuracy due to cross-reactivity ...
Candace S Bever, Catharine A Adams, Robert M Hnasko, Luisa W Cheng, Larry H Stanker   +4 more
doaj   +1 more source

Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver Histopathology. [PDF]

Int J Hepatol
Background. In spite of the scientific evidence supporting health advantages of mushrooms, some of them are seriously poisonous. The clinical picture of mushroom intoxication ranges from minor gastrointestinal symptoms to organ failure, such as liver failure and death. Method.
Anbardar MH, Soleimani N, Kazemi K, Jafarpour Z, Hasani M, Mohammadzadeh S, Torfehnezhad P, Jafarian S, Farhadi M, Sardari MS.   +9 more
europepmc   +2 more sources

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

Acute Liver Failure Caused by Amanita phalloides Poisoning

International Journal of Hepatology, 2012
Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which ...
Luca Santi, Caterina Maggioli, Marianna Mastroroberto, Manuel Tufoni, Lucia Napoli, Paolo Caraceni   +5 more
doaj   +1 more source

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source

Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimines and Sulfoximines

Angewandte Chemie, Volume 136, Issue 13, March 22, 2024.
Metal‐free, and high‐yielding sulfur‐imination using O‐(diphenylphosphinyl)hydroxyl amine to access sulfilimine salts and free‐NH sulfoximines has been reported. Its generality was evidenced using a broad substrate scope along with late‐stage functionalization of complex, biologically relevant substrates including a notorious amatoxin.
Shanal Gunasekera, Alla Pryyma, Jimin Jung, Rebekah Greenwood, Brian O. Patrick, David M. Perrin   +5 more
wiley   +2 more sources

Demystifying fungal systematics: A gateway to fungal literacy and societal/ecological relevance through familiar species

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 499-515, March 2026.
Fungal systematics can feel overwhelming given the vast species diversity within this kingdom, with numerous subgroups at every taxonomic rank. This often creates a disconnect between the undertsnidng of fungal taxonomic diversity and their societal relevance.
Anna Vaiana, Francis Martin, Rasmus Kjøller, Toby Spribille, Garima Singh   +4 more
wiley   +1 more source

Acute kidney injury related to wild mushrooms intoxication

Journal of Education, Health and Sport, 2020
The problem of mushroom intoxication has been brought up more often in both scientific journals and media, particularly in autumn – the period when mushroom hunting is most intense. Mushroom intoxication is mainly perceived as being associated with acute
Małgorzata Marchelek-Myśliwiec, Aleksandra Wilk, Agnieszka Turoń-Skrzypińska, Monika Nowosiad-Magda, Grazyna Dutkiewicz, Barbara Dołęgowska, Joanna Stępniewska, Kazimierz Ciechanowski, Barbara Wiszniewska   +8 more
doaj   +1 more source