Results 21 to 30 of about 9,049 (204)
GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets. [PDF]
Adv Sci (Weinh)GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wu W +17 more
europepmc +2 more sources
Protective effect of ganoderma acid A on liver injury induced by α-amanitin in mice
Zhongguo gonggong weisheng, 2023 ObjectiveTo investigate the protective mechanism of ganoderma acid A against α-amanitin-induced liver injury in mice. MethodsForty Kunming mice were divided into 4 groups intraperitoneally injected with solution (10 mL/kg) containing α-amanitin at ...
Lei LI, Yongting LIU, Chong ZHENG
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Toxicity and urinary metabolites of α-amanitin in mice
Zhongguo gonggong weisheng, 2022 ObjectiveTo explore toxicity and urinary metabolites of α-amanitin in mice with a 21-day toxicological experiment. MethodsTwenty ICR male mice were randomly divided into a control (n = 5) and three median lethal dose (LD50) groups (5 in each group) with ...
Zhi-jun WU, Wen-jin ZHAO, Hai-jiao LI
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Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics
Toxins, 2021 The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication.
Brendan Le Daré +2 more
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Establishment of Indirect Competitive ELISA Method for Detecting Amanitin in Mushroom
Shipin gongye ke-ji, 2022 Objective: This study aims to establish an indirect competitive enzyme-linked immunosorbent assay for the detection of amanitin (AMA) in mushroom. Methods: In this study, the hapten was obtained by introducing 6-aminocaproic acid into the carboxyl ...
Hebing LIU +3 more
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Toxins, 2014 Species in the mushroom genus Lepiota can cause fatal mushroom poisonings due to their content of amatoxins such as α-amanitin. Previous studies of the toxin composition of poisonous Lepiota species relied on analytical methods of low sensitivity or ...
R. Michael Sgambelluri +5 more
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Foods, 2022 Mushroom poisoning remains a serious food safety and health concern in some parts of the world due to its morbidity and mortality. Identification of mushroom toxins at an early stage of suspected intoxication is crucial for a rapid therapeutic decision ...
Isabel Barbosa +3 more
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Upstream CB1R Regulation of β-Adrenergic Memory Consolidation. [PDF]
HippocampusABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Rossato JI +9 more
europepmc +2 more sources
BMC Genomics, 2020 Background Amanitin-producing mushrooms, mainly distributed in the genera Amanita, Galerina and Lepiota, possess MSDIN gene family for the biosynthesis of many cyclopeptides catalysed by prolyl oligopeptidase (POP). Recently, transcriptome sequencing has
Zhengmi He +5 more
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Hypoadrenocorticism in a Dog Following Recovery from Alpha-Amanitin Intoxication
Veterinary Sciences, 2023 A 10-year-old, female spayed Labrador Retriever was referred for acute hepatopathy and urinary retention. Blood work from the initial presentation (day 0) revealed a severe, mixed hepatopathy. Over the course of the patient’s hospitalization, the patient
Emily A. Cohen +2 more
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