Erdosteine reduces cytotoxicity induced by alpha- and beta-amanitin, but not gamma-amanitin, in CA3 hepatocyte cultures [PDF]
Toxicon, 2022 Amanitin poisoning still has no particular, effective antidote. Erdosteine has been shown to protect numerous tissues, particularly those in the liver. This study investigates the potential therapeutic effects of erdosteine on alpha-, beta- and gamma-amanitin-induced hepatotoxicity in in vitro models.
Recep Bayram +3 more
core +8 more sources
Antiproliferative Effect of pHLIP-Amanitin
Biochemistry, 2013 Toxins could be effective anticancer drugs, if their selective delivery into cancer cells could be achieved. We have shown that the energy of membrane-associated folding of water-soluble membrane peptides of the pHLIP (pH low insertion peptide) family could be used to move cell-impermeable cargo across the lipid bilayer into the cytoplasm of cancer ...
Moshnikova, Anna +3 more
openaire +6 more sources
Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells [PDF]
ToxinsAmanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloides, α-
Willemien F. J. Hof +7 more
doaj +2 more sources
Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
doaj +2 more sources
Deadly Poisonous Turkish Mushrooms Containing Alpha Amanitin [PDF]
Düzce Tıp Fakültesi Dergisi, 2015 Mushroom poisoning is still a serious health problem for Turkey. The mushroom species which cause fatal mushroom poisoning have been reported to contain at least 98% alpha-amanitin.
Ilgaz Akata +3 more
doaj +1 more source
α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. [PDF]
PLoS ONE, 2017 We investigated the mechanisms of mushroom toxin resistance in the Drosophila Genetic Reference Panel (DGRP) fly lines, using genome-wide association studies (GWAS).
Chelsea L Mitchell +13 more
doaj +2 more sources
Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting [PDF]
Beilstein Journal of Organic Chemistry, 2018 RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 ...
Lizeth Bodero +9 more
doaj +2 more sources
Yüksek saflıkta beta amanitin üretimi
, 2012 Amaç: Beta amanitin nadiren bilimsel araştırmalarda kullanılmakta ve kullanımı gün geçtikçe artmaktadır. Piyasada bu ürün %90 saflıkta ticari olarak satılmaktadır. Bu araştırmada yüksek saflıkta beta amanitin üretme yöntemi tanımlanmıştır. Yöntem: Saflaştırma işlemi Amanita phalloides mantarlarından ekstraksiyonla yapılmıştır.
Yaykaşlı, Kürşat Oğuz +5 more
core +4 more sources
Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
europepmc +2 more sources
Convergence and parallelism in the evolution of plant metabolism. [PDF]
J Integr Plant BiolSimilar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Scossa F +4 more
europepmc +2 more sources