Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks. [PDF]
Compr Rev Food Sci Food SafABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Berglund NEW, Lankinen PV, Mikkonen KS.
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The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos. [PDF]
Adv Sci (Weinh)Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Yuan S +8 more
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Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
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Protective effect of ganoderma acid A on liver injury induced by α-amanitin in mice
Zhongguo gonggong weisheng, 2023 ObjectiveTo investigate the protective mechanism of ganoderma acid A against α-amanitin-induced liver injury in mice. MethodsForty Kunming mice were divided into 4 groups intraperitoneally injected with solution (10 mL/kg) containing α-amanitin at ...
Lei LI, Yongting LIU, Chong ZHENG
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Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination? [PDF]
BioessaysTranscription and 3D genome organization influence each other across spatial scales. Large‐scale architecture provides a relatively stable framework, while transcription and shared architectural factors refine local chromatin loops and domain boundaries. Specific long‐range interactions between regulatory elements and distal anchors can override domain‐
Yang D, Lei EP.
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Toxicity and urinary metabolites of α-amanitin in mice
Zhongguo gonggong weisheng, 2022 ObjectiveTo explore toxicity and urinary metabolites of α-amanitin in mice with a 21-day toxicological experiment. MethodsTwenty ICR male mice were randomly divided into a control (n = 5) and three median lethal dose (LD50) groups (5 in each group) with ...
Zhi-jun WU, Wen-jin ZHAO, Hai-jiao LI
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α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. [PDF]
PLoS ONE, 2017 We investigated the mechanisms of mushroom toxin resistance in the Drosophila Genetic Reference Panel (DGRP) fly lines, using genome-wide association studies (GWAS).
Chelsea L Mitchell +13 more
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Toxic Effects of Amanitins: Repurposing Toxicities toward New Therapeutics
Toxins, 2021 The consumption of mushrooms has become increasingly popular, partly due to their nutritional and medicinal properties. This has increased the risk of confusion during picking, and thus of intoxication.
Brendan Le Daré +2 more
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Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin. [PDF]
PLoS ONE, 2015 Insect resistance to toxins exerts not only a great impact on our economy, but also on the ecology of many species. Resistance to one toxin is often associated with cross-resistance to other, sometimes unrelated, chemicals. In this study, we investigated
Chelsea L Mitchell +5 more
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Foods, 2022 Mushroom poisoning remains a serious food safety and health concern in some parts of the world due to its morbidity and mortality. Identification of mushroom toxins at an early stage of suspected intoxication is crucial for a rapid therapeutic decision ...
Isabel Barbosa +3 more
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