Results 51 to 60 of about 104,829 (282)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Imaging and dosimetric study on direct flat-panel detector-based digital mammography system

Journal of Medical Physics, 2018
Introduction: Image quality of digital mammography system is generally defined by three primary physical parameters, namely, contrast, resolution, and noise.
Reena Sharma, S D Sharma, P S Sarkar, D Datta   +3 more
doaj   +1 more source

Design of Anisotropic Diffusion Hardware Fiber Phantoms [PDF]

, 2009
A gold standard for the validation of diffusion weighted magnetic resonance imaging (DW-MRI) in brain white matter (WM) is essential for clinical purposes but still not available.
Baete, Steven, De Deene, Yves, Fieremans, Els, Lemahieu, Ignace   +3 more
core   +1 more source

Phantom limb pain [PDF]

British Journal of Anaesthesia, 2000
Phantom pain is experienced by 60% to 80% of patients following limb amputation but is only severe in about 5% to 10% of cases. The mechanisms underlying pain in amputees are not fully understood, but factors in both the peripheral and central nervous system play a role.
Nikolajsen, Lone, Jensen, Troels Staehelin   +1 more
openaire   +5 more sources

Determining blood flow direction from short neurovascular surgical microscope videos

Healthcare Technology Letters, 2019
Neurovascular surgery aims to repair diseased or damaged blood vessels in the brain or spine. There are numerous procedures that fall under this category, and in all of them, the direction of blood flow through these vessels is crucial information ...
Reid Vassallo, Adam Rankin, Stephen P. Lownie, Stephen P. Lownie, Hitoshi Fukuda, Hidetoshi Kasuya, Benjamin W.Y. Lo, Terry Peters, Yiming Xiao   +8 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Use of an anthropomorphic hand phantom to verify the radiation intensity that is needed to modify the analog and digital radiographic quality

Brazilian Journal of Radiation Sciences, 2015
The radiology is a field of medicine that is in constantly expansion and advancing. This can be noticed with the transition from analog to digital radiology systems, it is important that professionals understand image formation in both systems in order ...
Caroline Kretezel Bandeira, Michele Patrícia Müller Mansur Vieira, José Eduardo dos Reis Felix   +2 more
doaj   +1 more source

Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study

, 2018
Physical head phantoms allow assessing source reconstruction procedures in electroencephalography and electrical stimulation profiles during transcranial electric stimulation. Volume conduction in the head is strongly influenced by the skull representing
Fiedler, Patrique, Haueisen, Jens, Hunold, Alexander, Strohmeier, Daniel   +3 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source